MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

Autor: Lore Becker, Eva Kling, Evelyn Schiller, Ramona Zeh, Anja Schrewe, Sabine M Hölter, Ilona Mossbrugger, Julia Calzada-Wack, Valentina Strecker, Ilka Wittig, Iulia Dumitru, Tina Wenz, Andreas Bender, Michaela Aichler, Dirk Janik, Frauke Neff, Axel Walch, Leticia Quintanilla-Fend, Thomas Floss, Raffi Bekeredjian, Valérie Gailus-Durner, Helmut Fuchs, Wolfgang Wurst, Thomas Meitinger, Holger Prokisch, Martin Hrabě de Angelis, Thomas Klopstock

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114918 (2014)

Recently, mutations in the mitochondrial translation optimization factor 1 gene (MTO1) were identified as causative in children with hypertrophic cardiomyopathy, lactic acidosis and respiratory chain defect. Here, we describe an MTO1-deficient mouse

Externí odkaz: https://doaj.org/article/5fb946e312a94325a7492aee89c6f092

Simultaneous Detection of Ricin and Abrin DNA by Real-Time PCR (qPCR)

Autor: Ilona Mossbrugger, Eva Felder, Mirko Lange, Roman Wölfel

Publikováno v: Toxins; Volume 4; Issue 9; Pages: 633-642
Toxins
Toxins, Vol 4, Iss 9, Pp 633-642 (2012)

Ricin and abrin are two of the most potent plant toxins known and may be easily obtained in high yield from the seeds using rather simple technology. As a result, both toxins are potent and available toxins for criminal or terrorist acts. However, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1438670983c47a5925a35ec13d383f4
https://doi.org/10.3390/toxins4090633

Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1-/- mice: critical role of IL-6

Autor: Thomas Miethke, Leticia Quintanilla-Martinez, Stefan Rose-John, Harald Dietrich, Michael Hammer, Jürgen Scheller, Nuria Rodriguez, Gabriele Weintz, Ilona Mossbrugger, Roland Lang

Publikováno v: J. Leukoc. Biol. 88, 579-587 (2010)

Dendritic cells interact with T cells in intestinal mucosa in an MHCII-dependent manner, suggesting presentation outside organized lymphoid tissue may be important in determining T cell phenotype. The MAPK phosphatase DUSP1 is an essential negative r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb3290cfc50a65859be5fff1fa4ee4a
https://doi.org/10.1189/jlb.0210083

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments

Autor: Julia Calzada-Wack, Eckhard Wolf, Ilona Mossbrugger, Leticia Quintanilla-Fend, Steven J. Romney, Sabine M. Hölter, Elizabeth A. Leibold, Martin Hrabě de Angelis, Thomas Klopstock, Ildiko Racz, Andreas Zimmer, Lillian Garrett, Lore Becker, Helmut Fuchs, Valerie Gailus-Durner, Kimberly B. Zumbrennen-Bullough, Birgit Rathkolb, Wolfgang Wurst

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98072 (2014)
PLOS ONE 9(6), e98072 (2014). doi:10.1371/journal.pone.0098072
PLoS ONE
PLoS ONE 9:e98072 (2014)
PLOS ONE

Iron Regulatory Protein 2 (Irp2, Ireb2) is a central regulator of cellular iron homeostasis in vertebrates. Two global knockout mouse models have been generated to explore the role of Irp2 in regulating iron metabolism. While both mouse models show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935c2cc30d947d2695fc9d9ce9dc56ca
http://europepmc.org/articles/PMC4045679?pdf=render

Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy

Autor: Ilona Mossbrugger, Ulrich Schweizer, Annette Grüters, Martin Hrabé de Angelis, Thomas Riebel, Leticia Quintanilla-Martinez, Kurt Werner Schmid, Josef Köhrle, Rémy Sapin, Sien-Yi Sheu, Eva K. Wirth, Heiko Krude, Karin Rothe, Marc Klein, Jazmin Chiu-Ugalde

Publikováno v: Eur. J. Endocrinol. 165, 555-561 (2011)

ContextThyroid hormone transport across the plasma membrane depends on transmembrane transport proteins, including monocarboxylate transporter 8 (MCT8). Mutations in MCT8 (or SLC16A2) lead to a severe form of X-linked psychomotor retardation, which i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66a843943322d6ed10f232f9f9f6543
https://pubmed.ncbi.nlm.nih.gov/21813593