Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ilona J.M. den Hartog"'
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Supplementary Tables S1-3. Table S1. IC25/50/75 and LC50 values of AT7519 for MYCN-amplified and non-MYCN-amplified neuroblastoma cell lines and cell seeding densities used to perform MTT cell proliferation assays (96-well plates). IC25/50/75 and LC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ebcc78bfc11a54290daef6f42738a0
https://doi.org/10.1158/1078-0432.22454805
https://doi.org/10.1158/1078-0432.22454805
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Purpose: MYCN-dependent neuroblastomas have low cure rates with current multimodal treatment regimens and novel therapeutic drugs are therefore urgently needed. In previous preclinical studies, we have shown that targeted inhibition of cyclin-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3cc7892d78b44f7f43dd133ff375f8
https://doi.org/10.1158/1078-0432.c.6522837.v1
https://doi.org/10.1158/1078-0432.c.6522837.v1
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Supplementary Materials and Methods. Detailed protocol for cell culturing, in vitro and in vivo Western Blotting, in vitro FACS analysis, in vitro synergy studies and in vivo immunohistochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd734fbdfced6b5caa6131627babed4
https://doi.org/10.1158/1078-0432.22454808
https://doi.org/10.1158/1078-0432.22454808
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Supplementary figures S1-8. Fig. S1. Sensitivity of neuroblastoma cells to AT7519 is partially dependent on MYCN amplification status. Fig. S2. AT7519 more potently induces PARP cleavage in MYCN-amplified neuroblastoma cells. Fig. S3. FACS plots show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423265fb51fd901d839d835c54768647
https://doi.org/10.1158/1078-0432.22454799.v1
https://doi.org/10.1158/1078-0432.22454799.v1
Autor:
Jan J. Molenaar, Louis Chesler, Huib N. Caron, Rogier Versteeg, Robbert J. Kok, Rolf W. Sparidans, Kevin Petrie, Simon P. Robinson, Albert Hallsworth, Yann Jamin, Carel J.M. van Noesel, Ilona J.M. den Hartog, Marli E. Ebus, Evon Poon, M. Emmy M. Dolman
Legends for supplementary figures S1-S8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164ae6e54525d419e2ea8febad561764
https://doi.org/10.1158/1078-0432.22454811
https://doi.org/10.1158/1078-0432.22454811
Autor:
Jan Koster, Rogier Versteeg, Laurel T. Bate-Eya, Huib N. Caron, Evan E. Santo, M. Emmy M. Dolman, Ellen M. Westerhout, Linda Schild, Jan J. Molenaar, Ilona J.M. den Hartog, Ida van der Ploeg
Publikováno v:
Oncotarget, 7(19), 27946-27958. Impact Journals
Oncotarget
Oncotarget
// Laurel T. Bate-Eya 1 , Ilona J.M. den Hartog 1 , Ida van der Ploeg 1 , Linda Schild 1 , Jan Koster 1 , Evan E. Santo 1 , Ellen M. Westerhout 1 , Rogier Versteeg 1 , Huib N. Caron 2 , Jan J. Molenaar 1 , M. Emmy M. Dolman 1 1 Department of Oncogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9574a9f53255b9988b87b6405d8d092f
https://doi.org/10.18632/oncotarget.8547
https://doi.org/10.18632/oncotarget.8547
Autor:
Ilona J.M. den Hartog, Rolf W. Sparidans, Jan H.M. Schellens, M. Emmy M. Dolman, Jan J. Molenaar, Jos H. Beijnen
Publikováno v:
Journal of pharmaceutical and biomedical analysis, 88, 216-220. Elsevier
A quantitative bioanalytical liquid chromatography–tandem mass spectrometric (LC–MS/MS) assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma was developed and validated. Plasma samples were pre-treated using protein precipitatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac5dd31e1957be085766bfa9f94fb7a
https://doi.org/10.1016/j.jpba.2013.08.051
https://doi.org/10.1016/j.jpba.2013.08.051
Autor:
Ilona J.M. den Hartog, Jan Koster, Ida van der Ploeg, Huib N. Caron, Danny A. Zwijnenburg, Linda Schild, Laurel T. Bate-Eya, Jan J. Molenaar, M. Emmy M. Dolman, Marli E. Ebus, Rogier Versteeg
Publikováno v:
European journal of cancer (Oxford, England, 50(3), 628-637. Elsevier Limited
Recently protocols have been devised for the culturing of cell lines from fresh tumours under serum-free conditions in defined neural stem cell medium. These cells, frequently called tumour initiating cells (TICs) closely retained characteristics of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db465e1efc890d27b54aeba296dc1593
https://doi.org/10.1016/j.ejca.2013.11.015
https://doi.org/10.1016/j.ejca.2013.11.015
Autor:
Marli E. Ebus, Rolf W. Sparidans, M. Emmy M. Dolman, Kevin Petrie, Evon Poon, Robbert J. Kok, Albert Hallsworth, Carel J. M. van Noesel, Rogier Versteeg, Yann Jamin, Ilona J.M. den Hartog, Huib N. Caron, Simon P. Robinson, Jan J. Molenaar, Louis Chesler
Publikováno v:
Clinical cancer research, 21(22), 5100-5109. American Association for Cancer Research Inc.
Purpose: MYCN-dependent neuroblastomas have low cure rates with current multimodal treatment regimens and novel therapeutic drugs are therefore urgently needed. In previous preclinical studies, we have shown that targeted inhibition of cyclin-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8242ba8557e2ede2bbf7001e840974
https://pure.amc.nl/en/publications/cyclindependent-kinase-inhibitor-at7519-as-a-potential-drug-for-mycndependent-neuroblastoma(ddc5feab-c87b-45f2-bf68-7e483f7f3868).html
https://pure.amc.nl/en/publications/cyclindependent-kinase-inhibitor-at7519-as-a-potential-drug-for-mycndependent-neuroblastoma(ddc5feab-c87b-45f2-bf68-7e483f7f3868).html
Autor:
Rolf W. Sparidans, Jan J. Molenaar, Ilona J.M. den Hartog, M. Emmy M. Dolman, Jos H. Beijnen, Jan H.M. Schellens
Publikováno v:
Journal of pharmaceutical and biomedical analysis, 92, 144-148. Elsevier
A quantitative bioanalytical liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay for sepantronium bromide (YM155), an inhibitor of survivin, was developed and validated. Under reduced light exposure, plasma samples were pre-treated using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819989dcc05323d4453cdf7d905821d5
https://pubmed.ncbi.nlm.nih.gov/24518133
https://pubmed.ncbi.nlm.nih.gov/24518133