Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ilona Faustova"'
Autor:
Rainis Venta, Ervin Valk, Mihkel Örd, Oleg Košik, Kaur Pääbo, Artemi Maljavin, Rait Kivi, Ilona Faustova, Nastassia Shtaida, Martin Lepiku, Kaidi Möll, Andreas Doncic, Mardo Kõivomägi, Mart Loog
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The decision of whether and when a cell divides is tightly controlled. Here, the authors show in yeast that there is a multi-step competition between different phosphorylation states and sites in the S phase CDK-Sic1 complex, which controls Sic1 degr
Externí odkaz:
https://doaj.org/article/4193f9a7643148afba8fdec5cd394703
Autor:
Mihkel Örd, Kait Kaarel Puss, Rait Kivi, Kaidi Möll, Tuuliki Ojala, Irina Borovko, Ilona Faustova, Rainis Venta, Ervin Valk, Mardo Kõivomägi, Mart Loog
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107757- (2020)
Summary: The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that hp can bind different motifs
Externí odkaz:
https://doaj.org/article/9335b639488448d8b175f643b4ec69dd
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9514 (2021)
Cyclins are the activators of cyclin-dependent kinase (CDK) complex, but they also act as docking scaffolds for different short linear motifs (SLiMs) in CDK substrates and inhibitors. According to the unified model of CDK function, the cell cycle is
Externí odkaz:
https://doaj.org/article/8bdcc9c5123a43d7a27a544727027c41
Autor:
Mihkel Örd, Mart Loog, David O. Morgan, Jonathan B. Asfaha, Christopher R. Carlson, Ilona Faustova
Publikováno v:
Current biology : CB, vol 32, iss 1
Curr Biol
bioRxiv
Curr Biol
bioRxiv
SummaryCell-cycle progression is driven by the phosphorylation of cyclin-dependent kinase (Cdk) substrates1–3. The order of substrate phosphorylation depends in part on the general rise in Cdk activity during the cell cycle4–7, together with vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a6fe378168c4dccd7529f50f277563
https://escholarship.org/uc/item/40g2p35s
https://escholarship.org/uc/item/40g2p35s
Publikováno v:
The EMBO Journal
Cyclin‐dependent kinases (CDKs), the master regulators of cell division, are activated by different cyclins at different cell cycle stages. In addition to being activators of CDKs, cyclins recognize various linear motifs to target CDK activity to s
Autor:
Mart Loog, Ilona Faustova
Publikováno v:
Molecular Cell. 81:1861-1862
Hossain et al. (2021) show that human origin recognition complex subunit ORC1 and licensing factor CDC6 interact when the pre-replicative complex forms in G1. Short linear motifs (SLiMs) in intrinsically disordered regions (IDRs) mediate this interac
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target
The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion680SPRRAR↓SV687forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c3085b5c361b90df6718c2c65c22262
https://doi.org/10.1101/2020.06.23.166900
https://doi.org/10.1101/2020.06.23.166900
Autor:
Kaidi Möll, Ervin Valk, Mihkel Örd, Kait Kaarel Puss, Rait Kivi, Ilona Faustova, Irina Borovko, Mart Loog, Mardo Kõivomägi, Rainis Venta, Tuuliki Ojala
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 11, Pp 107757-(2020)
Cell Reports, Vol 31, Iss 11, Pp 107757-(2020)
Summary The hydrophobic patch (hp), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the “RxL or Cy” docking motif. Here we show that hp can bind different motifs
Publikováno v:
Computational Biology and Chemistry. 48:40-44
Computational blind docking approach was used for mapping of possible binding sites in L-type pyruvate kinase subunit for peptides, RRASVA and the phosphorylated derivative RRAS(P"i)VA, which model the phosphorylatable N-terminal regulatory domain of