Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair

Autor: Ilmira Nurgatina, Pavel Dunaev, Firuza Bikinieva, Sergei Boichuk, Aida Aukhadieva, Elena Valeeva, A R Galembikova, Alexey Sabirov

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8842, p 8842 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 21; Issue 22; Pages: 8842

Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented for a broad spectrum of human malignancies supporting their growth and progression. Accumulating evidence has also implicated AKT as a potent modulator of anti-can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e833d18928ee1f6c4477c6823b664b77
https://pubmed.ncbi.nlm.nih.gov/33266502