Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma.

Autor: Omony J; Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany., Thölken C; Center for Synthetic Microbiology (SYNMIKRO), Philipps-University Marburg, Marburg, Germany., Salimi A; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany., Laubhahn K; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Department of Paediatric Allergology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Illi S; Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany., Weckmann M; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; University Children's Hospital, Luebeck, Germany., Grychtol R; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Rabe KF; German Center for Lung Research (DZL), LungenClinic Grosshansdorf GmbH, Airway Research Center North (ARCN), Grosshansdorf, Germany., Thiele D; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; Institute of Medical Biometry and Statistics (IMBS), University Medical Center Schleswig-Holstein, Luebeck, Germany., Foth S; University Children's Hospital Marburg, University of Marburg, Marburg, Germany.; German Center for Lung Research (DZL), University of Giessen, Marburg Lung Center (UGMLC), Giessen, Germany., Weber S; University Children's Hospital Marburg, University of Marburg, Marburg, Germany.; German Center for Lung Research (DZL), University of Giessen, Marburg Lung Center (UGMLC), Giessen, Germany., Brinkmann F; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; University Children's Hospital, Luebeck, Germany., Kopp MV; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany.; University Children's Hospital, Luebeck, Germany.; Department of Pediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland., Hansen G; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Renz H; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany.; Kilimanjaro Christian Medical University College (KCMUCo), Moshi, Tanzania., von Mutius E; Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Department of Paediatric Allergology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Schaub B; German Center for Lung Research (DZL), Comprehensive Pneumology Center Munich (CPC-M), Munich, Germany.; Department of Paediatric Allergology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Skevaki C; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany.; German Center for Lung Research (DZL), University of Giessen, Marburg Lung Center (UGMLC), Giessen, Germany.

Publikováno v: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [Pediatr Allergy Immunol] 2024 Jun; Vol. 35 (6), pp. e14172.

17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.

Autor: Jakwerth CA; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Weckmann M; Member of the German Center for Lung Research (DZL), Germany.; Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany.; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Illi S; Member of the German Center for Lung Research (DZL), Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.; Comprehensive Pneumology Center-Munich, Munich, Germany., Charles H; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Zissler UM; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Oelsner M; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Guerth F; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany., Omony J; Member of the German Center for Lung Research (DZL), Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.; Comprehensive Pneumology Center-Munich, Munich, Germany., Nemani SSP; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Grychtol R; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany., Dittrich AM; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany., Skevaki C; Member of the German Center for Lung Research (DZL), Germany.; Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics and., Foth S; Member of the German Center for Lung Research (DZL), Germany.; Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children's Hospital Marburg, University of Marburg, Marburg, Germany., Weber S; Member of the German Center for Lung Research (DZL), Germany.; Universities of Giessen and Marburg Lung Center, Philipps University Marburg and University Children's Hospital Marburg, University of Marburg, Marburg, Germany., Alejandre Alcazar MA; Member of the German Center for Lung Research (DZL), Germany.; Institute for Lung Health and Cardio-Pulmonary Institute, Universities of Giessen and Marburg Lung Center, Giessen, Germany.; Translational Experimental Pediatrics, Experimental Pulmonology, Department of Pediatrics.; Center for Molecular Medicine Cologne and Cologne Excellence Cluster on Stress Responses in Aging-associated Diseases, and.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., van Koningsbruggen-Rietschel S; Member of the German Center for Lung Research (DZL), Germany.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., Brock R; Member of the German Center for Lung Research (DZL), Germany.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., Blau S; Member of the German Center for Lung Research (DZL), Germany.; Pediatric Pulmonology and Allergology, Department of Pediatrics, Faculty of Medicine, University of Cologne and University Hospital Cologne, Cologne, Germany; and., Hansen G; Member of the German Center for Lung Research (DZL), Germany.; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hanover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hanover, Germany.; Cluster of Excellence 2115 (RESIST), Hannover Medical School, Hanover, Germany., Bahmer T; Member of the German Center for Lung Research (DZL), Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany.; Internal Medicine Department I, University Hospital Schleswig-Holstein-Campus Kiel, Kiel, Germany., Rabe KF; Member of the German Center for Lung Research (DZL), Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany.; LungenClinic Grosshansdorf GmbH and Medical Clinics, Christian Albrechts University, Kiel, Germany., Brinkmann F; Member of the German Center for Lung Research (DZL), Germany.; Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Research Center Borstel-Leibniz Lung Center, Borstel, Germany.; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Kopp MV; Department of Pediatric Pneumology and Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany.; Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Airway Research Center North, Borstel, Lübeck, Kiel, Grosshansdorf, Germany., Chaker AM; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Department of Otorhinolaryngology and Head and Neck Surgery, Medical School, Technical University of Munich, Munich, Germany., Schaub B; Member of the German Center for Lung Research (DZL), Germany.; Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.; Comprehensive Pneumology Center-Munich, Munich, Germany., von Mutius E; Member of the German Center for Lung Research (DZL), Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.; Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany., Schmidt-Weber CB; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany.; Member of the German Center for Lung Research (DZL), Germany.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Apr 15; Vol. 209 (8), pp. 947-959.

T-high asthma phenotypes across life span

Autor: Maison, N., Omony, J., Illi, S., Thiele, D., Skevaki, C., Dittrich, A.M., Bahmer, T., Rabe, K.F., Weckmann, M., Happle, C., Schaub, B., Meier, M., Foth, S., Rietschel, E., Renz, H., Hansen, G., Kopp, M.V., von Mutius, E., Grychtol, R., ALLIANCE Study Group (Marzi, C., Zissler, U.M., Schmidt-Weber, C.B.)

Publikováno v: Eur. Respir. J. 60:2102288 (2022)

RATIONALE: In adults, personalised asthma treatment targets patients with T2-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. OBJECTIVES: To define T2-high asthma with easily accessible bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3474::57aa173a464e8b578db93a20f8552c11
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64547

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