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pro vyhledávání: '"Illes, Peter"'
Epilepsy is one of the most common chronic diseases of the central nervous system (CNS). Treatment of epilepsy remains, however, a clinical challenge with over 30% of patients not responding to current pharmacological interventions. Complicating mana
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https://ul.qucosa.de/id/qucosa%3A89164
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Macrophages are mononuclear phagocytes which derive either from blood-borne monocytes or reside as resident macrophages in peripheral (Kupffer cells of the liver, marginal zone macrophages of the spleen, alveolar macrophages of the lung) and central
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https://ul.qucosa.de/id/qucosa%3A89103
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Autor:
Zhao, Ya-Fei, Ren, Wen-Jing, Zhang, Ying, He, Jin-Rong, Yin, Hai-Yan, Liao, Yang, Rubini, Patrizia, Deussing, Jan M., Verkhratsky, Alexei, Yuan, Zeng-Qiang, Illes, Peter, Tang, Yong
Extracellular adenosine 50-triphosphate (ATP) in the brain is suggested to be an etiological factor of major depressive disorder (MDD). It has been assumed that stress-released ATP stimulates P2X7 receptors (Rs) at the microglia, thereby causing neur
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https://ul.qucosa.de/id/qucosa%3A89098
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There is ongoing dispute on the question whether CNS neurons possess ATP-sensitive P2X7 receptors (Rs) or whether only non-neuronal cells bear this receptor-type and indirectly signal to the neighboring neurons. We genetically deleted P2X7Rs specific
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https://ul.qucosa.de/id/qucosa%3A87951
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Autor:
Aminin, Dmitry, Illes, Peter
ATP is stored in millimolar concentrations within the intracellular medium but may be released to extracellular sites either through the damaged plasma membrane or by means of various transporters. Extracellular ATP or its enzymatic breakdown product
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https://ul.qucosa.de/id/qucosa%3A89158
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Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world. We studied in rats the efficiency of electroacupuncture (E
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https://ul.qucosa.de/id/qucosa%3A84408
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Editorial on the Research Topic. Purinergic Signaling 2020: The State-of-The-Art Commented by the Members of the Italian Purine Club.
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84410
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P2X7 receptors are members of the ATP-gated cationic channel family with a preferential localization at the microglial cells, the resident macrophages of the brain. However, these receptors are also present at neuroglia (astrocytes, oligodendrocytes)
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https://ul.qucosa.de/id/qucosa%3A84351
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Autor:
Illes, Peter
ATP is a (co)transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-gated cationic channels termed P2X to induce rapid depolarization of the cell membrane. Within this receptor-channel family, the P2X7 receptor (R) allows the
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A89514
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Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by cell-damaging factors, they get transformed into an amoeboid phenoty
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https://ul.qucosa.de/id/qucosa%3A84734
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