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Autor:
Michelle McCabe, Monica Keith-Luzzi, Jun Xu, Illeaniz King, Andrea Whitcher-Johnstone, Rucha S. Sane, Donald J. Tweedie, Yongmei Li, Nicholas Johnstone
Publikováno v:
Drug Metabolism and Disposition. 43:1612-1618
Deleobuvir is a potent inhibitor of the hepatitis C virus nonstructural protein 5B polymerase. In humans, deleobuvir underwent extensive reduction to form CD 6168. This metabolite was not formed in vitro in aerobic incubations with human liver micros