Immunogenicity and safety of a 3-antigen hepatitis B vaccine vs a single-antigen hepatitis B vaccine : a phase 3 randomized clinical trial

Autor: Johanna Spaans, Bebi Yassin-Rajkumar, Peter Ruane, Timo Vesikari, Saul N. Faust, Amina Z Haggag, Bruce Rankin, Benita Ukkonen, Michael Levin, Michael Manns, Satu Kokko, Gerald Vallieres, Carl Griffin, David E. Anderson, Vlad Popovic, Francisco Diaz-Mitoma, Mary B Manning, Azhar Toma, Hamilton Sah, Clancy L. Cone, Nathalie Machluf, Nathan Segall, Williams Hayes, Mark A. Turner, Aino Forsten, Outi Laajalahti, Maija Rössi, Anitta Ahonen, Mark E Kutner, Naveen Garg, M N Ramasamy, Adam Finn, Isabel Leroux-Roels, Olli Henriksson, Dennis Reich, Geert Leroux-Roels, Pierre Van Damme, Pauliina Paavola, Catherine Cosgrove, Barbara E. Rizzardi, Ilkka Seppä, Ronnie Aronson, Samir Arora

Publikováno v: JAMA NETWORK OPEN
JAMA Network Open
Vesikari, T, Finn, A, van Damme, P, Leroux-Roels, I, Leroux-Roels, G, Segall, N, Toma, A, Vallieres, G, Aronson, R, Reich, D, Arora, S, Ruane, P J, Cone, C L, Manns, M, Cosgrove, C, Faust, S N, Ramasamy, M N, Machluf, N, Spaans, J N, Yassin-Rajkumar, B, Anderson, D, Popovic, V, Diaz-Mitoma, F 2021, ' Immunogenicity and Safety of a 3-Antigen Hepatitis B Vaccine vs a Single-Antigen Hepatitis B Vaccine : A Phase 3 Randomized Clinical Trial ', JAMA Network Open, vol. 4, no. 10, e2128652, pp. e2128652 . https://doi.org/10.1001/jamanetworkopen.2021.28652
JAMA Netw Open

Importance There is a need for improved immunogenicity of hepatitis B virus (HBV) vaccines among young adults with risk of infection. Objectives To demonstrate manufacturing equivalence of a 3-antigen (3A) HBV vaccine, evaluate noninferiority of sero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb4f067c6f9010c585085536e06f1af
https://hdl.handle.net/1854/LU-8759301

Effectiveness of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D-Conjugated Vaccine (PHiD-CV) Against Carriage and Acute Otitis Media-A Double-Blind Randomized Clinical Trial in Finland

Autor: Ilkka Seppä, Timo Vesikari, Patricia Lommel, Taneli Puumalainen, Sonia Schoonbroodt, Anu Soininen, Dorota Borys, Lode Schuerman, Magali Traskine, Aino Forstén, Tarja Kaijalainen, Marjan Hezareh, Marta Moreira

Publikováno v: Journal of the Pediatric Infectious Diseases Society

UNLABELLED After administering the 10-valent pneumococcal polysaccharide nontypeable Haemophilus influenzae protein D-conjugated vaccine (PHiD-CV) to children aged 2-18 months, we observed a reduction in vaccine-type nasopharyngeal carriage, resultin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453793cfd95e8022da1b9d584164f1ed
https://pubmed.ncbi.nlm.nih.gov/28064237

Genetic association study of childhood aggression across raters, instruments, and age

Autor: Hill F. Ip, Camiel M. van der Laan, Eva M. L. Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M. Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A. Wang, Gretchen Saunders, Ville Karhunen, Anke R. Hammerschlag, Daniel E. Adkins, Richard Border, Roseann E. Peterson, Joseph A. Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S. Ahluwalia, Felix R. Day, Jouke-Jan Hottenga, Andrea G. Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J. Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G. Scott, Anna Vinkhuyzen, Andrey A. Shabalin, Robin Corley, Luke M. Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E. Davies, Erik A. Ehli, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C.E.M. Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C. Verhulst, Najaf Amin, Alyce M. Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J. Rose, André G. Uitterlinden, Andrew C. Heath, Pamela Madden, Jan Haavik, Jennifer R. Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S. Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K. Henders, Abdullah Mamun, Jackob M. Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L. Wall, Judy L. Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T. Raitakari, John R. B. Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L. John Horwood, Martin Kennedy, Richie Poulton, Lindon J. Eaves, Hermine H. Maes, John Hewitt, William E. Copeland, Elizabeth J. Costello, Gail M. Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E. Moffitt, Andrew Whitehouse, Craig E. Pennell, Kelly L. Klump, S. Alexandra Burt, Danielle M. Dick, Ted Reichborn-Kjennerud, Nicholas G. Martin, Sarah E. Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A. Hartman, Albertine J. Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors

Externí odkaz: https://doaj.org/article/882fa84e3ace4249a3c5e7bb582ea021

Examining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts

Autor: Jaakko Laaksonen, Pashupati P. Mishra, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Emma Raitoharju, Nina Mononen, Maija Lepistö, Henrikki Almusa, Pekka Ellonen, Nina Hutri-Kähönen, Markus Juonala, Olli Raitakari, Mika Kähönen, Jukka T. Salonen, Terho Lehtimäki

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract High blood pressure (BP) is a major risk factor for many noncommunicable diseases. The effect of mitochondrial DNA single-nucleotide polymorphisms (mtSNPs) on BP is less known than that of nuclear SNPs. We investigated the mitochondrial gene

Externí odkaz: https://doaj.org/article/d1f4a2fafbc746db82b61c974ee8830e

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Autor: Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival perc

Externí odkaz: https://doaj.org/article/43040ac329044c8a980e87b5849d94cd