Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ilkka P. Mattila"'
Autor:
Joonatan Mattila, Silja Sormunen, Nelli Heikkilä, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13486-13496 (2023)
Abstract Background The number of mutations in cancer cells is an important predictor of a positive response to cancer immunotherapy. It has been suggested that the neoantigens produced by these mutations are more immunogenic than nonmutated tumor an
Externí odkaz:
https://doaj.org/article/a1fd196e9f9b4512b675514b1c392ed5
Autor:
Nelli Heikkilä, Iivari Kleino, Reetta Vanhanen, Dawit A. Yohannes, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila
Publikováno v:
Data in Brief, Vol 35, Iss , Pp 106751- (2021)
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive re
Externí odkaz:
https://doaj.org/article/394d75d0da81404ab6d2e1527f3d4877
Publikováno v:
International Journal of Pediatrics, Vol 2010 (2010)
Externí odkaz:
https://doaj.org/article/6e4438a105454228ba5be27c6038d541
Autor:
Jari Saramäki, Nelli Heikkilä, Dawit A. Yohannes, Reetta Vanhanen, T. Petteri Arstila, Ilkka P. Mattila, Iivari Kleino
Publikováno v:
Molecular Immunology. 127:112-123
A highly diverse repertoire of T cell antigen receptors (TCR) is created in the thymus by recombination of gene segments and the insertion or deletion of nucleotides at the junctions. Using next-generation TCR sequencing we define here the features o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141824122e6fd4942f2996d0acb51df
https://doi.org/10.1016/j.molimm.2020.09.003
https://doi.org/10.1016/j.molimm.2020.09.003
Autor:
Nelli Heikkilä, Ilkka P. Mattila, Jari Saramäki, T. Petteri Arstila, T. Sakari Jokiranta, Silja Sormunen, Reetta Vanhanen, Seppo Meri, Dawit A. Yohannes, Päivi Saavalainen, David Hamm, Hanna Jarva
Publikováno v:
European Journal of Immunology. 50:748-751
We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement and generation of junctional sequences, the thymic selections seem largely stochastic and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdcc885d2098414af350bbcb4730ddb
https://doi.org/10.1002/eji.201948404
https://doi.org/10.1002/eji.201948404
Autor:
Tuure Kinnunen, Silja Sormunen, Taina Härkönen, Jari Saramäki, Nelli Heikkilä, Emmi Leena Ihantola, Joonatan Mattila, Mikael Knip, Ilkka P. Mattila, T. Petteri Arstila
The T-cell receptor (TCR) repertoire is generated in a semistochastic process of gene recombination and pairing of TCRα to TCRβ chains with the estimated total TCR diversity of >108. Despite this high diversity, similar or identical TCR chains are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab24dfb9a0fddd727f3f10a8a28443a9
http://hdl.handle.net/10138/330936
http://hdl.handle.net/10138/330936
Autor:
Nelli, Heikkilä, Iivari, Kleino, Reetta, Vanhanen, Dawit A, Yohannes, Ilkka P, Mattila, Jari, Saramäki, T Petteri, Arstila
Publikováno v:
Data in Brief
T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR repertoire undergoes thymic selections where non-functional and potentially autoreactive re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd039341a11ae01de11d1e409c72bb6b
https://pubmed.ncbi.nlm.nih.gov/33553521
https://pubmed.ncbi.nlm.nih.gov/33553521
Autor:
Annukka Ritvanen, Tiina Ojala, Tommi Pätilä, Mika Gissler, Tero Vahlberg, Jukka T. Salminen, Juha Rasanen, Eero Jokinen, Juha Puntila, Johanna Hautala, Ilkka P. Mattila, Jaana Pihkala, Emmi Helle
Publikováno v:
Acta obstetricia et gynecologica ScandinavicaREFERENCES. 99(12)
Introduction Newborn infants with transposition of the great arteries (d-TGA) need immediate care for an optimal outcome. This study comprised a nationwide 11-year population-based cohort of d-TGA infants, and assessed whether the implementation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98534c0b468ac6870ab5f1516435d163
https://pubmed.ncbi.nlm.nih.gov/32640036
https://pubmed.ncbi.nlm.nih.gov/32640036
Autor:
Johanna Hautala, Mika Gissler, Tommi Pätilä, Emmi Helle, Jari Räsänen, Vedran Stefanovic, Ilkka P. Mattila, Jaana Pihkala, Eero Jokinen, Taisto Sarkola, Aydin Tekay, Annukka Ritvanen, Olli Pitkänen-Argillander, Tiina Ojala
OBJECTIVE To evaluate whether a nationwide prenatal anomaly screening programme improves detection rates of univentricular heart (UVH) and transposition of great arteries (TGA), and whether maternal risk factors for severe fetal heart disease affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc8d9a4308cc72f0d0a9903ef6aa55b
http://hdl.handle.net/10138/308712
http://hdl.handle.net/10138/308712
Publikováno v:
Cellular Immunology. 347:104026
The natural CD25 + FOXP3 + regulatory T cell (Treg) population is generated as a distinct lineage in the thymus, but the details of Treg development in humans remain unclear, and the timing of Treg commitment is also contested. Here we have analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429a3acd38ef1adbe1e8af727dae3cae
https://doi.org/10.1016/j.cellimm.2019.104026
https://doi.org/10.1016/j.cellimm.2019.104026