Building up analgesia in humans via the endogenous μ-opioid system by combining placebo and active tDCS: a preliminary report.

Autor: Marcos F DosSantos, Ilkka K Martikainen, Thiago D Nascimento, Tiffany M Love, Misty D DeBoer, Heidi M Schambra, Marom Bikson, Jon-Kar Zubieta, Alexandre F DaSilva

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102350 (2014)

Transcranial Direct Current Stimulation (tDCS) is a method of non-invasive brain stimulation that has been frequently used in experimental and clinical pain studies. However, the molecular mechanisms underlying tDCS-mediated pain control, and most im

Externí odkaz: https://doaj.org/article/3e6ad0367acb4c4987cfb4c5a77b8b17

Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation

Autor: Javier Ballester, Anne K. Baker, Ilkka K. Martikainen, Vincent Koppelmans, Jon-Kar Zubieta, Tiffany M. Love

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-7 (2022)

Abstract µ-Opioid receptors (MOR) are a major target of endogenous and exogenous opioids, including opioid pain medications. The µ-opioid neurotransmitter system is heavily implicated in the pathophysiology of chronic pain and opioid use disorder a

Externí odkaz: https://doaj.org/article/9e620463bb6041019c7ede6134518b4d

Neurotransmitters behind pain relief with transcranial magnetic stimulation - positron emission tomography evidence for release of endogenous opioids

Autor: Tero Taiminen, Nora Hagelberg, Salla Lamusuo, Jussi Hirvonen, Riitta Parkkola, Satu K. Jääskeläinen, Semi Helin, Arja Virtanen, Ilkka K. Martikainen, Pauliina Lindholm, Antti Pertovaara, Jarmo Hietala

Publikováno v: European Journal of Pain. 21:1505-1515

Background Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. Objectives To investigate the possible neurobiological correlates of cortical neurostimulation for the pain relief. Methods W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2c41dcacd7ed71c7bd70df4da56b92
https://doi.org/10.1002/ejp.1052

μ ‐Opioid activation in the midbrain during migraine allodynia – brief report II

Autor: Misty DeBoer, Alexandre F. DaSilva, Yolanda R. Smith, Tiffany M. Love, Jon Kar Zubieta, Eric Maslowski, Ilkka K. Martikainen, Thiago D. Nascimento, Sarah K. Lucas, Robert A. Koeppe, Marcos F. DosSantos, Hendrik van Holsbeeck

Publikováno v: Annals of Clinical and Translational Neurology

We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1ab0686772e413a2b3cff787fb33aa
https://doi.org/10.1002/acn3.66

Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects

Autor: Lauri Tuominen, Nora Hagelberg, Antti Pertovaara, Jarmo Hietala, Kjell Någren, Ilkka K. Martikainen, Harry Scheinin, Ullamari Pesonen, Sargo Aalto

Publikováno v: Hagelberg, N, Aalto, S, Tuominen, L, Pesonen, U, Någren, K, Hietala, J, Scheinin, H, Pertovaara, A & Martikainen, I K 2012, ' Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects ', Neuroscience Letters, vol. 521, no. 1, pp. 11-4 . https://doi.org/10.1016/j.neulet.2012.05.042

Previous PET studies in healthy humans have shown that brain μ-opioid receptor activation during experimental pain is associated with reductions in the sensory and affective ratings of the individual pain experience. The aim of this study was to fin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf9dee977245b4c8029df8d551caa34
https://doi.org/10.1016/j.neulet.2012.05.042