Výsledky vyhledávání - "Ilker K. Sariyer"

Akademický článek

Delivering CRISPR to the HIV-1 reservoirs

Autor: Theodore E. Gurrola, Samuel N. Effah, Ilker K. Sariyer, Will Dampier, Michael R. Nonnemacher, Brian Wigdahl

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most complex and difficult viral infections to cure. The difficulty in developing curative strategies arises in large part from the development of latent viral reservoi

Externí odkaz: https://doaj.org/article/70da3e89cc3348ef9745129dc63ee8b8

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Akademický článek

CRISPR based editing of SIV proviral DNA in ART treated non-human primates

Autor: Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo, Kamel Khalili

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated

Externí odkaz: https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe4

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Akademický článek

Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy

Autor: Hager Mohamed, Theodore Gurrola, Rachel Berman, Mackenzie Collins, Ilker K. Sariyer, Michael R. Nonnemacher, Brian Wigdahl

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for which successful therapeutic options are still being investigated. Challenges facing current drugs that are part of the established life-long antiretroviral

Externí odkaz: https://doaj.org/article/07cd16400d2a4186931c3780183dcef6

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Akademický článek

Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy

Autor: Andrew Atkins, Cheng-Han Chung, Alexander G. Allen, Will Dampier, Theodore E. Gurrola, Ilker K. Sariyer, Michael R. Nonnemacher, Brian Wigdahl

Publikováno v: Frontiers in Genome Editing, Vol 3 (2021)

As genome-editing nucleases move toward broader clinical applications, the need to define the limits of their specificity and efficiency increases. A variety of approaches for nuclease cleavage detection have been developed, allowing a full-genome su

Externí odkaz: https://doaj.org/article/1476ae5fefcf4442bc7e226b35f23b18

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Akademický článek

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)

Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o

Externí odkaz: https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b

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Akademický článek

Binge-Like Exposure to Ethanol Enhances Morphine's Anti-nociception in B6 Mice

Autor: Sulie L. Chang, Wenfei Huang, Haijun Han, Ilker K. Sariyer

Publikováno v: Frontiers in Psychiatry, Vol 9 (2019)

Elevation of the blood ethanol concentration (BEC) to > 80 mg/dL (17.4 mM) after binge drinking enhances inflammation in brain and neuroimmune signaling pathways. Morphine abuse is frequently linked to excessive drinking. Morphine exerts its actions

Externí odkaz: https://doaj.org/article/fc19a475c26446c5b98db1b9e3828cac

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Akademický článek

Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials

Autor: Sarah Vakili, Taha Mohseni Ahooyi, Shadan S. Yarandi, Martina Donadoni, Jay Rappaport, Ilker K. Sariyer

Publikováno v: Brain Sciences, Vol 10, Iss 7, p 424 (2020)

Several factors can contribute to neuroinflammatory disorders, such as cytokine and chemokines that are produced and released from peripherally derived immune cells or from locally activated cells such as microglia and perivascular macrophages in the

Externí odkaz: https://doaj.org/article/2525f8f8c87741e0ab050d8ba3f92a00

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