Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ilkcan Cokgor"'
Autor:
David A. Reardon, Gamal Akabani, R. Edward Coleman, Allan H. Friedman, Henry S. Friedman, James E. Herndon, Ilkcan Cokgor, Roger E. McLendon, Charles N. Pegram, James M. Provenzale, Jennifer A. Quinn, Jeremy N. Rich, Lorna V. Regalado, John H. Sampson, Timothy D. Shafman, Carol J. Wikstrand, Terence Z. Wong, Xiao-Guang Zhao, Michael R. Zalutsky, Darell D. Bigner
Publikováno v:
Journal of Clinical Oncology. 20:1389-1397
PURPOSE: To assess the efficacy and toxicity of intraresection cavity 131I-labeled murine antitenascin monoclonal antibody 81C6 and determine its true response rate among patients with newly diagnosed malignant glioma. PATIENTS AND METHODS: In this p
Publikováno v:
Journal of Neuro-Oncology. 60:79-88
Neoplastic meningitis, which is the diffuse involvement of the leptomeninges by infiltrating cancer cells, may be caused by many systemic tumors. The treatment options for neoplastic meningitis disease remain unsatisfactory. In this review article, w
Autor:
Mary Lou Affronti, Maureen Early, Sandra Tourt-Uhlig, Jennifer A. Quinn, A. H. Friedman, Sara L. Zaknoen, James E. Herndon, Valerie Stafford-Fox, Roger E. McLendon, John H. Sampson, Henry S. Friedman, Sridharan Gururangan, Shari Edwards, James M. Provenzale, Jeremy N. Rich, Ilkcan Cokgor
Publikováno v:
Neuro-Oncology. 3:246-250
Both Gliadel wafers [1,3-bis(2-chloroethyl)-1-nitrosourea] and temozolomide (TEMO) have been shown in independent studies to prolong survival of patients with recurrent malignant glioma following surgery and radiotherapy. On the basis of preclinical
Autor:
James M. Provenzale, Lee M. Zehngebot, Gamal Akabani, Cynthia D. Guy, Michael R. Zalutsky, Allan H. Friedman, Carol J. Wikstrand, Henry S. Friedman, Ilkcan Cokgor, Darell D. Bigner
Publikováno v:
Cancer. 91:1809-1813
Even with novel chemotherapeutic agents and external beam radiation therapy, the prognosis of neoplastic meningitis secondary to malignant melanoma is still dismal. The authors report a case study of a 46-year-old white female who presented with prog
Autor:
Gamal Akabani, Michael R. Zalutsky, Xiao-Guang Zhao, Roger E. McLendon, R. Edward Coleman, Allan H. Friedman, James E. Herndon, Sandra H. Bigner, Timothy D. Shafman, Ana M. Garcia-Turner, Darell D. Bigner, Carol J. Wikstrand, Ilkcan Cokgor, Henry S. Friedman, Charles N. Pegram, James M. Provenzale, Chien-Tsun Kuan
Publikováno v:
Journal of Clinical Oncology. 18:3862-3872
PURPOSE: To determine the maximum-tolerated dose (MTD) of iodine-131 (131I)–labeled 81C6 antitenascin monoclonal antibody (mAb) administered clinically into surgically created resection cavities (SCRCs) in malignant glioma patients and to identify
Autor:
Henry S. Friedman, James Pluda, Jennifer A. Quinn, Reginald B. Ewesuedo, Lina Long, Allan H. Friedman, Ilkcan Cokgor, O. Michael Colvin, Michael M. Haglund, David M. Ashley, Jeremy N. Rich, John Sampson, Anthony E. Pegg, Robert C. Moschel, Roger E. McLendon, James M. Provenzale, Elizabeth S. Stewart, Sandra Tourt-Uhlig, Ana M. Garcia-Turner, James E. Herndon, Darell D. Bigner, M. Eileen Dolan
Publikováno v:
Journal of Clinical Oncology. 18:3522-3528
PURPOSE: The major mechanism of resistance to alkylnitrosourea therapy involves the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chloroethylation or methylation damage from the O6 position of guanine. O6-benzylguanine
Autor:
Henry S. Friedman, David Graden, Peter J. Houghton, Roger E. McLendon, Janice E. Zilisch, Allan H. Friedman, Ilkcan Cokgor, Susan G. Arbuck, Tracy Kerby, Scott Fields
Publikováno v:
Cancer. 85:1160-1165
BACKGROUND Topotecan activity was evaluated for the treatment of malignant glioma. METHODS Sixty-three patients with newly diagnosed (n = 25) or recurrent (n = 38) malignant glioma were treated with topotecan at a dose of 2.6 mg/m2 over a 72-hour per
Publikováno v:
Cancer and Metastasis Reviews. 18:451-464
The development of immunotherapeutic protocols for the treatment of human CNS neoplasia over the past two decades has been impressive. Several crucial aspects have been defined, characterized, and in many cases, optimized (Wikstrand CJ, Zalutsky MR,
Autor:
James M. Pluda, DM Kokkinakis, Robert C. Moschel, ME Dolan, Michael M. Haglund, Henry S. Friedman, Darell D. Bigner, Jeremy N. Rich, Tracy Kerby, Allan H. Friedman, David M. Ashley, Ilkcan Cokgor, James E. Herndon, S. C. Schold, Roger E. McLendon, Anthony E. Pegg
Publikováno v:
Journal of Clinical Oncology. 16:3570-3575
PURPOSE The major mechanism of resistance to alkylnitrosourea therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or methylation damage from the O6-position of guanine. O6-benzylguanine (O6-BG)
Autor:
Susan Boulton, Allan H. Friedman, Gamal Akabani, Linda Cleveland, Roger E. McLendon, Carol J. Wikstrand, Ilkcan Cokgor, James E. Herndon, Henry S. Friedman, David A. Reardon, Darell D. Bigner, Michael R. Zalutsky
Publikováno v:
Nuclear medicine and biology. 34(4)
The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting of a (13