Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ilka Wilhelmi"'
Autor:
Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Vanessa Schmidt, Till Karwen, Angel Loza‐Valdes, Akim Strohmeyer, Saskia Reuter, Minhee Noh, Magdalena Wit, Izabela Hawro, Sabine Mocek, Christina Fey, Alexander E Mayer, Mona C Löffler, Ilka Wilhelmi, Marco Metzger, Eri Ishikawa, Sho Yamasaki, Monika Rau, Andreas Geier, Mohammed Hankir, Florian Seyfried, Martin Klingenspor, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
Abstract Lipids are the most energy‐dense components of the diet, and their overconsumption promotes obesity and diabetes. Dietary fat content has been linked to the lipid processing activity by the intestine and its overall capacity to absorb trig
Externí odkaz:
https://doaj.org/article/7c21b9b7b80e406aaf05b383b2b65ed9
Autor:
Ilka Wilhelmi, Stephan Grunwald, Niclas Gimber, Oliver Popp, Gunnar Dittmar, Anup Arumughan, Erich E. Wanker, Thomas Laeger, Jan Schmoranzer, Oliver Daumke, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101151- (2021)
Objective: Hormone secretion from metabolically active tissues, such as pancreatic islets, is governed by specific and highly regulated signaling pathways. Defects in insulin secretion are among the major causes of diabetes. The molecular mechanisms
Externí odkaz:
https://doaj.org/article/1448fb0556da4f3e9a968b2dfe04626d
Autor:
Anneke Gässler, Charline Quiclet, Oliver Kluth, Pascal Gottmann, Kristin Schwerbel, Anett Helms, Mandy Stadion, Ilka Wilhelmi, Wenke Jonas, Meriem Ouni, Frank Mayer, Joachim Spranger, Annette Schürmann, Heike Vogel
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101042- (2020)
Objective: Altered gene expression contributes to the development of type 2 diabetes (T2D); thus, the analysis of differentially expressed genes between diabetes-susceptible and diabetes-resistant mouse models is an important tool for the determinati
Externí odkaz:
https://doaj.org/article/778cc7a0ad9d48c0a3bf529338b48bfb
Autor:
Maria Rödiger, Martin W. Werno, Ilka Wilhelmi, Christian Baumeier, Deike Hesse, Nina Wettschureck, Stefan Offermanns, Kyungyeun Song, Michael Krauß, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 167-179 (2018)
Objective: Intracellular vesicle trafficking maintains cellular structures and functions. The assembly of cargo-laden vesicles at the trans-Golgi network is initiated by the ARF family of small GTPases. Here, we demonstrate the role of the trans-Golg
Externí odkaz:
https://doaj.org/article/22416836e05b488d83740840d4fa6ec5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8597 (2021)
Dysfunctional islets of Langerhans are a hallmark of type 2 diabetes (T2D). We hypothesize that differences in islet gene expression alternative splicing which can contribute to altered protein function also participate in islet dysfunction. RNA sequ
Externí odkaz:
https://doaj.org/article/c7c8ed17c7904c8daa0ad929115c9a00
Autor:
Ilka Wilhelmi, Regina Kanski, Alexander Neumann, Olga Herdt, Florian Hoff, Ralf Jacob, Marco Preußner, Florian Heyd
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The transport of secretory proteins from the endoplasmic reticulum to the Golgi depends on COPII-coated vesicles. Here, the authors show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secreto
Externí odkaz:
https://doaj.org/article/5eac4601c94e4e0ea0fcc66ec338cff3
Autor:
David G. Lambright, Lorraine C. Santy, Fang-Jen S. Lee, Marielle E. Yohe, Joel B. Dacks, Pei Wen Chen, Jacqueline Cherfils, Annette Schürmann, Elizabeth Sztul, James E. Casanova, Ilka Wilhelmi, Paul A. Randazzo, Richard A. Kahn
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2019, 30 (11), pp.1249-1271. ⟨10.1091/mbc.E18-12-0820⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2019, 30 (11), pp.1249-1271. ⟨10.1091/mbc.E18-12-0820⟩
International audience; Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a protein family in the aggregate yields additional information, as on
Autor:
Ilka Wilhelmi, Oliver Popp, Niclas Gimber, Thomas Laeger, Jan Schmoranzer, Gunnar Dittmar, Erich E. Wanker, Anup Arumughan, Stephan Grunwald, Annette Schürmann, Oliver Daumke
Publikováno v:
Molecular metabolism, 45:101151
Molecular Metabolism
Molecular Metabolism, Vol 45, Iss, Pp 101151-(2021)
Molecular Metabolism
Molecular Metabolism, Vol 45, Iss, Pp 101151-(2021)
Objective Hormone secretion from metabolically active tissues, such as pancreatic islets, is governed by specific and highly regulated signaling pathways. Defects in insulin secretion are among the major causes of diabetes. The molecular mechanisms u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ebb86a0b837ebfcafe2d29cf370425
https://repository.publisso.de/resource/frl:6427782
https://repository.publisso.de/resource/frl:6427782
Autor:
Stefan Offermanns, Martin W. Werno, Christian Baumeier, Maria Rödiger, Kyungyeun Song, Michael Krauß, Deike Hesse, Nina Wettschureck, Annette Schürmann, Ilka Wilhelmi
Publikováno v:
Molecular Metabolism, Vol 8, Iss, Pp 167-179 (2018)
Molecular Metabolism
Molecular metabolism, 8:167-179
Molecular Metabolism
Molecular metabolism, 8:167-179
Objective Intracellular vesicle trafficking maintains cellular structures and functions. The assembly of cargo-laden vesicles at the trans-Golgi network is initiated by the ARF family of small GTPases. Here, we demonstrate the role of the trans-Golgi
Autor:
Thomas Laeger, Ilka Wilhelmi, Annette Schürmann, A Kamitz, Josefine Würfel, Christian Baumeier
Publikováno v:
Diabetologia
Aims/hypothesis Fibroblast growth factor 21 (FGF21) is considered to be a promising therapeutic candidate for the treatment of type 2 diabetes. However, as FGF21 levels are elevated in obese and diabetic conditions we aimed to test if exogenous FGF21