Výsledky vyhledávání - "Ilka Maschmeyer"

Akademický článek

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

Autor: Thi-Phuong Tao, Ilka Maschmeyer, Edward L. LeCluyse, Eda Rogers, Katrin Brandmair, Silke Gerlach, Julia Przibilla, Fredy Kern, Camille Genies, Carine Jacques, Abdulkarim Najjar, Andreas Schepky, Uwe Marx, Jochen Kühnl, Nicola J. Hewitt

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established a skin and liver HUMIMIC Chip

Externí odkaz: https://doaj.org/article/5068186205ee485da21ca6a4409cc5d3

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Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model

Autor: Ilka Maschmeyer, Julia Przibilla, Thi Phuong Tao, Camille Genies, Carine Jacques-Jamin, Andreas Schepky, Uwe Marx, Katrin Brandmair, Nicola J. Hewitt, Jochen Kühnl, Silke Gerlach

Publikováno v: Journal of Applied Toxicology. 41:1553-1567

We used TissUse's HUMIMIC Chip2 microfluidic model, incorporating reconstructed skin models and liver spheroids, to investigate the impact of consumer-relevant application scenarios on the metabolic fate of the hair dye, 4-amino-2-hydroxytoluene (AHT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20001faf92cda0c6cc4e81a1c2453cca
https://doi.org/10.1002/jat.4146

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Organ-on-a-Chip

Autor: Ilka, Maschmeyer, Sofia, Kakava

Publikováno v: Advances in biochemical engineering/biotechnology. 179

Limitations of the current tools used in the drug development process, cell cultures, and animal models have highlighted the need for a new powerful tool that can emulate the human physiology in vitro. Advances in the field of microfluidics have made

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09647b00a7b648fcdafbcc11e77e33af
https://pubmed.ncbi.nlm.nih.gov/32948885

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Organ-on-a-Chip

Autor: Ilka Maschmeyer, Sofia Kakava

Publikováno v: Microfluidics in Biotechnology ISBN: 9783031041877

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3dfeee6367164f06153199acc5751c1
https://doi.org/10.1007/10_2020_135

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A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

Autor: Ellen Goossens, Ilka Maschmeyer, Uwe Marx, W Cools, I Ruetschle, Yoni Baert, A Oehme, Alexandra Lorenz

Publikováno v: Human reproduction (Oxford, England). 35(5)

STUDY QUESTIONIs it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip?SUMMARY ANSWERMulti-organ-chip co-cultures of human liver and testis equivalents were maintained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c5c528251aa255624032ff8381e815
https://pubmed.ncbi.nlm.nih.gov/32390056

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Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model

Autor: Uwe Marx, Camille Genies, Julia Przibilla, Silke Gerlach, Nicola J. Hewitt, Thamée Rings, Katrin Brandmair, Ursula Müller-Vieira, Thi Phuong Tao, Ilka Maschmeyer, Jochen Kühnl, Andreas Schepky, Carine Jaques-Jamin

Publikováno v: Toxicology. 448:152637

Microphysiological systems (MPS) aim to mimic the dynamic microenvironment and the interaction between tissues. While MPS exist for investigating pharmaceuticals, the applicability of MPS for cosmetics ingredients is yet to be evaluated. The HUMIMIC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b05ca619dc6c326ff27f16dd8223733
https://doi.org/10.1016/j.tox.2020.152637

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Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip

Autor: A. Winter, Thi Phuong Tao, Silvya Stuchi Maria-Engler, Uwe Marx, Renata Spagolla Napoleão Tavares, Monika Schäfer-Korting, Lorena Rigo Gaspar, Roland Lauster, Ilka Maschmeyer, Christian Zoschke

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Skin model cultivation under static conditions limits the observation of the toxicity to this single organ. Biology-inspired microphysiological systems associating skin with a liver in the same circulating medium provide a more comprehensive insight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b08b44f7071bbfba888ab17844270ec
https://doi.org/10.1016/j.ijpharm.2020.119788

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Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

Autor: Kerstin Schirrmann, Marian Raschke, Uwe Marx, Alexandra Lorenz, Juliane Hübner, Sarah Gräßle, Tobias Hasenberg, Roland Lauster, Thomas Steger-Hartmann, Susanne Schnurre, Isabel Rütschle, Ilka Maschmeyer

Publikováno v: Hübner, J, Raschke, M, Rütschle, I, Gräßle, S, Hasenberg, T, Schirrmann, K, Lorenz, A, Schnurre, S, Lauster, R, Maschmeyer, I, Steger-Hartmann, T & Marx, U 2018, ' Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model ', Scientific Reports, vol. 8, no. 1, pp. 15010 . https://doi.org/10.1038/s41598-018-33462-3
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Antibody therapies targeting the epithelial growth factor receptor (EGFR) are being increasingly applied in cancer therapy. However, increased tumour containment correlates proportionally with the severity of well-known adverse events in skin. The pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd832de174861c9935521d080ffc3303
https://www.research.manchester.ac.uk/portal/en/publications/simultaneous-evaluation-of-antiegfrinduced-tumour-and-adverse-skin-effects-in-a-microfluidic-human-3d-coculture-model(f75273f7-e8ab-4945-81f0-aa9a72b7f31f).html

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Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Autor: Daniela Gunne, Ilka Maschmeyer, Sophie Bauer, Annika Winter, Shalini Andersson, Uwe Marx, Kajsa P. Kanebratt, Lorna Ewart, Tommy B. Andersson, Carina Ämmälä, Charlotte Wennberg Huldt, Isabell Durieux, William G. Haynes

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Human in vitro physiological models studying disease and drug treatment effects are urgently needed as more relevant tools to identify new drug targets and therapies. We have developed a human microfluidic two-organ-chip model to study pancreatic isl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc36efd976ad754b6c983f5500b04b3
https://pubmed.ncbi.nlm.nih.gov/29362490

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Abstract LB-027: Evaluation of EGFR induced on-target and target-mediated adverse effects in a 3D human lung tumour/skin microphysiological co-culture system

Autor: Juliane Huebner, Marian Raschke, Katharina Schimek, Isabel Ruetschle, Sarah Graessle, Susanne Schnurre, Roland Lauster, Ilka Maschmeyer, Thomas Steger-Hartmann, Uwe Marx

Publikováno v: Cancer Research. 79:LB-027

Organs-on-a-chip or microphysiological systems (MPS) are increasingly contributing to the preclinical characterization of mode of action and adverse events of drug candidates. The recent advent of robust human multi-organ-chip systems enables the est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6d3f86b1882b6bd8b6403b9bebb40b4
https://doi.org/10.1158/1538-7445.am2019-lb-027

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