Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ilka Fuchs"'
Autor:
Thomas Mika, Deepak Vangala, Matthias Eckhardt, Paul La Rosée, Christoph Lange, Kai Lehmberg, Charlotte Wohlschläger, Saskia Biskup, Ilka Fuchs, Jasmin Mann, Stephan Ehl, Klaus Warnatz, Roland Schroers
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Hemophagocytic lymphohistiocytosis (HLH) is a disorder of uncontrolled immune activation with distinct clinical features including fever, cytopenia, splenomegaly, and sepsis-like symptoms. In a young adolescent patient a novel germline GATA2 variant
Externí odkaz:
https://doaj.org/article/c458839039cf429d97ae8978a6f9df55
Autor:
Thomas Mika, Swetlana Ladigan-Badura, Abdelouahid Maghnouj, Bakr Mustafa, Susanne Klein-Scory, Alexander Baraniskin, Sascha Döhring, Ilka Fuchs, Stephan Ehl, Stephan A. Hahn, Roland Schroers
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
In relapsed and refractory multiple myeloma (MM), adoptive cell therapies (ACT) including CAR-T-cells are under clinical investigation. However, relapse due to T-cell exhaustion or limited persistence is an obstacle. Before ACT are considered in MM,
Externí odkaz:
https://doaj.org/article/d94bd402625c41a988eef188e6eb6f34
Autor:
Christian Klemann, Myrian Esquivel, Aude Magerus-Chatinet, Myriam R. Lorenz, Ilka Fuchs, Nathalie Neveux, Martin Castelle, Jan Rohr, Claudia Bettoni da Cunha, Martin Ebinger, Robin Kobbe, Bernhard Kremens, Florian Kollert, Eleonora Gambineri, Kai Lehmberg, Markus G. Seidel, Kathrin Siepermann, Thomas Voelker, Volker Schuster, Sigune Goldacker, Klaus Schwarz, Carsten Speckmann, Capucine Picard, Alain Fischer, Frederic Rieux-Laucat, Stephan Ehl, Anne Rensing-Ehl, Benedicte Neven
Publikováno v:
Haematologica, Vol 102, Iss 2 (2017)
Externí odkaz:
https://doaj.org/article/fb31d3dbf753479a86faf8e112d592e1
Autor:
Anne Rensing-Ehl, Ales Janda, Myriam R. Lorenz, Beryl P. Gladstone, Ilka Fuchs, Mario Abinun, Michael Albert, Karina Butler, Andrew Cant, Anna-Maria Cseh, Martin Ebinger, Sigune Goldacker, Sophie Hambleton, Holger Hebart, Leonora Houet, Karim Kentouche, Ingrid Kühnle, Kai Lehmberg, Ester Mejstrikova, Charlotte Niemeyer, Milen Minkov, Olaf Neth, Gregor Dückers, Stephan Owens, Joachim Rösler, Freimut H. Schilling, Volker Schuster, Markus G. Seidel, Petr Smisek, Martina Sukova, Peter Svec, Thomas Wiesel, Benjamin Gathmann, Klaus Schwarz, Werner Vach, Stephan Ehl, Carsten Speckmann
Publikováno v:
Haematologica, Vol 98, Iss 12 (2013)
Clinical and genetic heterogeneity renders confirmation or exclusion of autoimmune lymphoproliferative syndrome difficult. To re-evaluate and improve the currently suggested diagnostic approach to patients with suspected FAS mutation, the most freque
Externí odkaz:
https://doaj.org/article/c2dcea0072414a2b9458bbcb66bb9499
Autor:
Maria Elena Maccari, Pascal Schneider, Cristian Roberto Smulski, Andrea Meinhardt, Fernando Pinto, Luis Ignacio Gonzalez-Granado, Catharina Schuetz, Mauricio Pablo Sica, Miriam Gross, Ilka Fuchs, Patrick Kury, Maximilian Heeg, Tatjana Vocat, Laure Willen, Caroline Thomas, Regina Hühn, Aude Magerus, Myriam Lorenz, Klaus Schwarz, Frederic Rieux-Laucat, Stephan Ehl, Anne Rensing-Ehl
Publikováno v:
The Journal of allergy and clinical immunology.
Fas ligand (FasL) is expressed by activated T cells and induces death in target cells upon binding to Fas. Loss-of-function FAS or FASLG mutations cause autoimmune-lymphoproliferative syndrome (ALPS) characterized by expanded double-negative T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e483890c123d524be847bf57ffa24d0f
https://pubmed.ncbi.nlm.nih.gov/36621650
https://pubmed.ncbi.nlm.nih.gov/36621650
Autor:
Stephan Ehl, Klaus Warnatz, Nora Naumann-Bartsch, Anika Erxleben, Geoffroy Andrieux, Myriam Ricarda Lorenz, Robin Kobbe, Maximilian Heeg, Melanie Boerries, Gerd Horneff, Gregor Dückers, Stefan Schönberger, Klaus Schwarz, Julian Staniek, Jan Rohr, Andreas Mackensen, Hermann Eibel, Stephen Owens, Miriam Groß, Patrick Kury, Julian Thalhammer, Marita Führer, Andreas P. Frei, Pascal Schneider, Charlotte M. Niemeyer, Catharina Schütz, Carla N. Castro, Markus G. Seidel, Maria Elena Maccari, Ilka Fuchs, Simon Völkl, Friedrich G. Kapp, Marta Rizzi, Ursula Warthorst, R Kolb, Christian Klemann, Maurizio Miano, Tomas Kalina, Sebastian Fuchs, Rolf Backofen, Petr Smisek, Dirk Holzinger, Christoph König, Carsten Speckmann, Sabine Jägle, Arif B. Ekici, Bodo Grimbacher, Bertram Bengsch, Anne Rensing-Ehl
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol. 218, no. 2, pp. e20192191
The Journal of experimental medicine, vol. 218, no. 2, pp. e20192191
Maccari et al. identify a physiological population of highly proliferative CD38+CD45RA+, IL-10–producing TCRαβ+ T cells. They can be CD4+, CD8+, or double-negative and are controlled by FAS and CTLA4, while their survival is enhanced by mTOR and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11700627dab114dd095ef0baab6bc4e9
http://europepmc.org/articles/PMC7658692
http://europepmc.org/articles/PMC7658692
Autor:
Ilka Fuchs, Kai Lehmberg, Udo zur Stadt, Roland Elling, Benedikt Spielberger, Carla N. Castro, Carsten Speckmann, Petra Kaiser-Labusch, Julian Thalhammer, Sebastian Fuchs, Christian Klemann, Robbert G. M. Bredius, Philipp Henneke, Sandra Ammann, Maximilian Heeg, Lydia Martin-Martin, Ina Hainmann, Caroline von Spee-Mayer, Stephan Ehl, Gerd Horneff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127f68e715cede9e15f242e5943b85ab
https://doi.org/10.1016/j.jaci.2019.09.002
https://doi.org/10.1016/j.jaci.2019.09.002
Autor:
Sandra Ammann, Maximilian Heeg, Sebastian F. N. Bode, Anne Rensing-Ehl, Stephan Ehl, Christian Klemann, Ilka Fuchs, Gritta Janka, Kai Lehmberg, Udo zur Stadt
Publikováno v:
European Journal of Immunology
Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening inflammatory syndrome characterized by hyperactivation of lymphocytes and histiocytes. T cells play a key role in HLH pathogenesis, but their differentiation pattern is not well charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d059f16b40a6034f796f2493c4c917ef
http://europepmc.org/articles/PMC7163530
http://europepmc.org/articles/PMC7163530
Autor:
Peter Olbrich, Ursula Warthorst, Marina Garcia-Prat, Fabian Beier, Carsten Speckmann, Sebastian Fuchs, Mónica S. Ventura Ferreira, Christian Klemann, Tim H. Brümmendorf, Stephan Ehl, Pere Soler-Palacín, Justin Roche, Paola Cura Daball, Olaf Neth, Sandra Ammann, Anne Rensing-Ehl, Timothy Ronan Leahy, Myriam Ricarda Lorenz, Ilka Fuchs, Niall Conlon, Klaus Schwarz
Publikováno v:
Immunology and cell biology. 96(10)
Premature T-cell immunosenescence with CD57+ CD8+ T-cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c570f2267472809a6ff2827a3a49f43
https://pubmed.ncbi.nlm.nih.gov/29790605
https://pubmed.ncbi.nlm.nih.gov/29790605
Autor:
Stephan Ehl, Deniz Guloglu, Corina Cianga, Sandra Ammann, Robert Thimme, Ömür Ardeniz, Bengü Gerçeker, Caroline Keck, Annette Schmitt-Graeff, Klaus Warnatz, Aydan Ikinciogullari, Bianca Martin, Hüseyin Onay, Ilka Fuchs, Ulrich Salzer, Paul Fisch, Tuğrul Dereli, Petru Cianga, Klaus Schwarz, Susanne Unger
Publikováno v:
Journal of Allergy and Clinical Immunology. 136:392-401
Background Most patients with MHC class I (MHC-I) deficiency carry genetic defects in transporter associated with antigen processing 1 (TAP1) or TAP2 . The clinical presentation can vary, and about half of the patients have severe skin disease. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c6a7f36f89c21a6a714f145067b2f9
https://doi.org/10.1016/j.jaci.2014.12.1937
https://doi.org/10.1016/j.jaci.2014.12.1937