Výsledky vyhledávání - "Iljana Gaffar"

Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation

Autor: Xiangwei Xiao, Ray Zimmerman, Iljana Gaffar, Zewen Song, Chiyo Shiota, Krishna Prasadan, Shane Fischbach, John Wiersch, Ping Guo, Piotr Witkowski, George K. Gittes, Sabarinathan Ramachandran

Publikováno v: Endocrinology. 157:1348-1356

Although islet transplantation is an effective treatment for severe diabetes, its broad application is greatly limited due to a shortage of donor islets. Suppression of TGFβ receptor signaling in β-cells has been shown to increase β-cell prolifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2cb56ea2fd3af1a677bec7902c1e95
https://doi.org/10.1210/en.2015-1986

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Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells

Autor: Chiyo Shiota, Shane Fischbach, Krishna Prasadan, Xiangwei Xiao, Christopher Rymer, John Wiersch, Zewen Song, Ping Guo, Yousef El-Gohary, Iljana Gaffar, George K. Gittes, Farzad Esni, Sidhartha Tulachan, Csaba Galambos

Publikováno v: Endocrinology. 157:166-175

A key question in diabetes research is whether new β-cells can be derived from endogenous, nonendocrine cells. The potential for pancreatic ductal cells to convert into β-cells is a highly debated issue. To date, it remains unclear what anatomical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5759f65bbeed76dc79739cded6897b
https://doi.org/10.1210/en.2015-1175

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Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes

Autor: Lauren Peirish, Yousef El-Gohary, Xiangwei Xiao, Iljana Gaffar, Krishna Prasadan, Sohail Z. Husain, Shane Fischbach, Chiyo Shiota, Zewen Song, George K. Gittes, John Wiersch, Ping Guo

Publikováno v: Nature Protocols. 9:2719-2724

Genetic manipulations, with or without lineage tracing for specific pancreatic cell types, are very powerful tools for studying diabetes, pancreatitis and pancreatic cancer. Nevertheless, the use of Cre/loxP systems to conditionally activate or inact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14137d8a6dd9808fc6a84a7a30ef3cca
https://doi.org/10.1038/nprot.2014.183

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Pancreatic duct cells as a source of VEGF in mice

Autor: Iljana Gaffar, Yousef El-Gohary, Chiyo Shiota, George K. Gittes, John Wiersch, Shane Fischbach, Ping Guo, Xiangwei Xiao, Krishna Prasadan

Publikováno v: Diabetologia. 57:991-1000

Vascular endothelial growth factor (VEGF) is essential for proper pancreatic development, islet vascularisation and insulin secretion. In the adult pancreas, VEGF is thought to be predominantly secreted by beta cells. Although human duct cells have p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6507610e9abad543f8beba6d09f3bb
https://doi.org/10.1007/s00125-014-3179-y

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M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

Autor: Ping Guo, John Wiersch, Xiangwei Xiao, Lauren Peirish, Iljana Gaffar, Shane Fischbach, Chiyo Shiota, Zewen Song, Krishna Prasadan, George K. Gittes, Yousef El-Gohary

Publikováno v: Proceedings of the National Academy of Sciences. 111

Determination of signaling pathways that regulate beta-cell replication is critical for beta-cell therapy. Here, we show that blocking pancreatic macrophage infiltration after pancreatic duct ligation (PDL) completely inhibits beta-cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe0df6637dc8010fbee28c3bd06381
https://doi.org/10.1073/pnas.1321347111

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Neurogenin3 Activation Is Not Sufficient to Direct Duct-to-Beta Cell Transdifferentiation in the Adult Pancreas*

Autor: Ping Guo, Xiangwei Xiao, Yousef El-Gohary, Krishna Prasadan, Iljana Gaffar, George K. Gittes, Chiyo Shiota, John Wiersch

It remains controversial whether adult pancreatic ducts harbor facultative beta cell progenitors. Because neurogenin3 (Ngn3) is a key determinant of pancreatic endocrine cell neogenesis during embryogenesis, many studies have also relied upon Ngn3 ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41369f7976f24b900abd6781273d3346
https://europepmc.org/articles/PMC3757194/

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Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass

Autor: Iljana Gaffar, Chiyo Shiota, Zean Chen, Krishna Prasadan, John Wiersch, George K. Gittes, Ping Guo, Yousef El-Gohary, Xiangwei Xiao

Publikováno v: The Journal of biological chemistry. 288(12)

VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-specific vasculature, and Insulin secretion. However, two key questions remain. First, is VEGF-A release from beta cells coupled to VEGF-A production in beta c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694eb8c0d2c6579c774ef814d0fc9ddd
https://pubmed.ncbi.nlm.nih.gov/23378532

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