Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Ilja V Khavrutskii"'
Autor:
Sidhartha Chaudhury, Gregory D Gromowski, Daniel R Ripoll, Ilja V Khavrutskii, Valmik Desai, Anders Wallqvist
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
BACKGROUND:A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a centra
Externí odkaz:
https://doaj.org/article/fa9414519755456db726302c20606355
Autor:
Daniel R Ripoll, Ilja V Khavrutskii, Sidhartha Chaudhury, Jin Liu, Robert A Kuschner, Anders Wallqvist, Jaques Reifman
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002665 (2012)
Quantitatively predicting changes in drug sensitivity associated with residue mutations is a major challenge in structural biology. By expanding the limits of free energy calculations, we successfully identified mutations in influenza neuraminidase (
Externí odkaz:
https://doaj.org/article/c990e87185354733a26e436e70ef2d5b
Autor:
Ilja V. Khavrutskii, Sidhartha Chaudhury, Sabrina M. Stronsky, Donald W. Lee, Jacqueline G. Benko, Anders Wallqvist, Sina Bavari, Christopher L. Cooper
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Recent advances in the next-generation sequencing of B-cell receptors (BCRs) enable the characterization of humoral responses at a repertoire-wide scale and provide the capability for identifying unique features of immune repertoires in response to d
Externí odkaz:
https://doaj.org/article/0101d168de454f9ba9d3af170f5eca7c
Autor:
Anders Wallqvist, Ilja V. Khavrutskii
Publikováno v:
ChemistrySelect. 2:1885-1890
Organophosphate nerve agents inhibit the enzyme acetylcholinesterase (AChE), which is involved in nerve signal transduction, by forming covalent adducts with its catalytic serine residue. AChE adducts with soman and sarin nerve agents undergo dealkyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a45ec01922eb81ab31bcf1ee0fd8806f
https://doi.org/10.1002/slct.201601828
https://doi.org/10.1002/slct.201601828
Publikováno v:
Biochemistry. 58(52)
Cathepsin A (CatA, EC 3.4.16.5, UniProtKB P10619) is a human lysosomal carboxypeptidase. Counterintuitively, crystal structures of CatA and its homologues show a cluster of Glu and Asp residues binding the C-terminal carboxylic acid of the product or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9f69d1f356675690ba6491cf213184
https://pubmed.ncbi.nlm.nih.gov/31192586
https://pubmed.ncbi.nlm.nih.gov/31192586
Autor:
Jaimee R. Compton, Mark A. Guelta, Patricia M. Legler, Kayla D. Bouknight, Steven P. Harvey, Ilja V. Khavrutskii, Kayla M. Jurkouich
Publikováno v:
Biochemical Pharmacology. 177:113980
Human Cathepsin A (CatA) is a lysosomal serine carboxypeptidase of the renin-angiotensin system (RAS) and is structurally similar to acetylcholinesterase (AChE). CatA can remove the C-terminal amino acids of endothelin I, angiotensin I, Substance P,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22280da86fe82737a2b8244db9629624
https://doi.org/10.1016/j.bcp.2020.113980
https://doi.org/10.1016/j.bcp.2020.113980
Autor:
Christopher L. Cooper, Sina Bavari, Donald W. Lee, Sabrina M. Stronsky, Anders Wallqvist, Sidhartha Chaudhury, Jacqueline G. Benko, Ilja V. Khavrutskii
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Recent advances in the next-generation sequencing of B-cell receptors (BCRs) enable the characterization of humoral responses at a repertoire-wide scale and provide the capability for identifying unique features of immune repertoires in response to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e40b4d911640ead36e4b262c4a7a0c5
https://pubmed.ncbi.nlm.nih.gov/28855898
https://pubmed.ncbi.nlm.nih.gov/28855898
Autor:
Ilja V. Khavrutskii, Sidhartha Chaudhury, Anders Wallqvist, Daniel R. Ripoll, Gregory D. Gromowski, Valmik Desai
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005395 (2017)
Background A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234bee0ee5a37e3b3ff2ae50be88c8bf
http://europepmc.org/articles/PMC5336305
http://europepmc.org/articles/PMC5336305
Autor:
Christopher L. Cooper, Donald W. Lee, Sina Bavari, Ilja V. Khavrutskii, Sidhartha Chaudhury, Anders Wallqvist
Publikováno v:
Frontiers in Immunology
The somatic diversity of antigen-recognizing B-cell receptors (BCRs) arises from Variable (V), Diversity (D), and Joining (J) (VDJ) recombination and somatic hypermutation (SHM) during B-cell development and affinity maturation. The VDJ junction of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c811e2e87261679a1df1afcfe8b9b01
http://europepmc.org/articles/PMC5239784
http://europepmc.org/articles/PMC5239784
Cryo-electron-microscopy (cryo-EM) structures of flaviviruses reveal significant variation in epitope occupancy across different monoclonal antibodies that have largely been attributed to epitope-level differences in conformation or accessibility tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098a8565ddf33d975f3becffb0c4eafd
https://europepmc.org/articles/PMC5071605/
https://europepmc.org/articles/PMC5071605/
