MTH1 Inhibition Alleviates Immune Suppression and Enhances the Efficacy of Anti-PD-L1 Immunotherapy in Experimental Mesothelioma.

Autor: Magkouta SF; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens 10676 Athens, Greece., Vaitsi PC; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens 10676 Athens, Greece., Iliopoulou MP; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens 10676 Athens, Greece., Pappas AG; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens 10676 Athens, Greece., Kosti CN; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens 10676 Athens, Greece., Psarra K; Department of Immunology-Histocompatibility, Evangelismos Hospital, 10675 Athens, Greece., Kalomenidis IT; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, Evangelismos Hospital, School of Medicine, National and Kapodistrian University of Athens 10676 Athens, Greece.

Publikováno v: Cancers [Cancers (Basel)] 2023 Oct 12; Vol. 15 (20). Date of Electronic Publication: 2023 Oct 12.

MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage.

Autor: Magkouta SF; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Pappas AG; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Vaitsi PC; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Agioutantis PC; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Pateras IS; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece., Moschos CA; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Iliopoulou MP; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Kosti CN; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Loutrari HV; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece., Gorgoulis VG; Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation of the Academy of Athens, Athens, Greece.; Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom., Kalomenidis IT; 'Marianthi Simou Laboratory', 1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, School of Medicine, Evangelismos Hospital, Athens, Greece.

Publikováno v: JCI insight [JCI Insight] 2020 Jun 18; Vol. 5 (12). Date of Electronic Publication: 2020 Jun 18.

Correlative analysis from a phase I clinical trial of intrapleural administration of oncolytic vaccinia virus (Olvi-vec) in patients with malignant pleural mesothelioma.

Autor: Chintala, Navin K., Choe, Jennie K., McGee, Erin, Bellis, Rebecca, Saini, Jasmeen K., Banerjee, Srijita, Moreira, Andre L., Zauderer, Marjorie G., Adusumilli, Prasad S., Rusch, Valerie W.

Publikováno v: Frontiers in Immunology; 2/16/2023, Vol. 14, p1-19, 19p