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Glymphatic influx and clearance are perturbed in Huntington's disease.

Autor: Liu H; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Chen L; F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA.; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Zhang C; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Liu C; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Li Y; F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA.; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cheng L; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ouyang Y; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rutledge C; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Anderson J; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wei Z; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Zhang Z; F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Lu H; F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA.; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., van Zijl PC; F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA.; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Iliff JJ; Veterans Integrated Service Network (VISN) 20 Northwest Mental Illness Research, Education, and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, Washington, USA.; Department of Psychiatry and Behavioral Sciences and.; Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA., Xu J; F.M. Kirby Research Center, Kennedy Krieger Research Institute, Baltimore, USA.; Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Duan W; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Oct 22; Vol. 9 (20). Date of Electronic Publication: 2024 Oct 22.

Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players.

Autor: Jung LB; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany., Wiegand TLT; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany., Tuz-Zahra F; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Tripodis Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University School of Medicine, Boston, Massachusetts., Iliff JJ; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle.; Department of Neurology, University of Washington School of Medicine, Seattle.; VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington., Piantino J; Department of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health and Science University, Portland., Arciniega H; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Rehabilitation Medicine, NYU Grossman School of Medicine, New York, New York., Kim CL; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany., Pankatz L; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany., Bouix S; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Département de génie logiciel et TI, École de technologie supérieure, Université du Québec, Montreal, Canada., Lin AP; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Alosco ML; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts., Daneshvar DH; Department of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Harvard Medical School, Boston., Mez J; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts., Sepehrband F; Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles., Rathi Y; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston., Pasternak O; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Coleman MJ; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Adler CH; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona Scottsdale, Arizona., Bernick C; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada., Balcer L; Department of Neurology, NYU Grossman School of Medicine, New York, New York.; Department of Population Health, NYU Grossman School of Medicine, New York, New York.; Department of Ophthalmology, NYU Grossman School of Medicine, New York, New York., Cummings JL; Chambers-Grundy Center for Transformative Neuroscience, Pam Quirk Brain Health and Biomarker Laboratory, Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas., Reiman EM; Banner Alzheimer's Institute, University of Arizona, Arizona State University, Translational Genomics Research Institute, and Arizona Alzheimer's Consortium, Phoenix., Stern RA; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.; Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts.; Department of Neurosurgery, Boston University School of Medicine, Boston, Massachusetts., Shenton ME; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Koerte IK; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; cBRAIN, Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany.

Publikováno v: JAMA network open [JAMA Netw Open] 2024 Aug 01; Vol. 7 (8), pp. e2428687. Date of Electronic Publication: 2024 Aug 01.

Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function.

Autor: Braun M; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA., Sevao M; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Keil SA; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Gino E; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Wang MX; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Lee J; VISN 20 Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA., Haveliwala MA; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Klein E; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Agarwal S; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Pedersen T; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Rhodes CH; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD 20817, USA.; Department of Pathology, F Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.; DoD/USU Brain Tissue Repository, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Jansson D; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Cook D; VISN 20 Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Peskind E; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA., Perl DP; Department of Pathology, F Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.; DoD/USU Brain Tissue Repository, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Piantino J; Division of Child Neurology, Department of Pediatrics, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, OR 97239, USA., Schindler AG; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.; VISN 20 Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Iliff JJ; VISN 20 Northwest Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.; Department of Neurology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Jun 03; Vol. 147 (6), pp. 2214-2229.

Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.

Autor: Richmond SB; Department of Applied Physiology and Kinesiology, University of Florida, 1864, Stadium Rd., Gainesville, FL, USA., Seidler RD; Department of Applied Physiology and Kinesiology, University of Florida, 1864, Stadium Rd., Gainesville, FL, USA.; Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA., Iliff JJ; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA.; VISN 20 Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA, USA., Schwartz DL; Layton-NIA Oregon Aging and Alzheimer's Disease Research Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.; Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA., Luther M; Department of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, OR, USA., Silbert LC; Layton-NIA Oregon Aging and Alzheimer's Disease Research Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA.; Veteran's Affairs Portland Health Care System, Neurology, Portland, OR, USA., Wood SJ; NASA Johnson Space Center, Houston, TX, USA., Bloomberg JJ; NASA Johnson Space Center, Houston, TX, USA., Mulder E; German Aerospace Center (DLR), Cologne, Germany., Lee JK; Department of Applied Physiology and Kinesiology, University of Florida, 1864, Stadium Rd., Gainesville, FL, USA.; German Aerospace Center (DLR), Cologne, Germany., De Luca A; Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands., Piantino J; Department of Pediatrics, Division of Child Neurology, Doernbecher Children's Hospital, Oregon Health and Science University, Portland, OR, USA. piantino@ohsu.edu.

Publikováno v: NPJ microgravity [NPJ Microgravity] 2024 Mar 01; Vol. 10 (1), pp. 24. Date of Electronic Publication: 2024 Mar 01.