The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model

Autor: Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachter

Publikováno v: Glia. 70:1117-1132

An active role of neuroinflammation and the NLRP3 inflammasome in Alzheimer's disease and related tauopathies is increasingly identified, supporting NLRP3 as an interesting therapeutic target. However, its effect on tau-associated neurodegeneration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9189b28316f63d13f1d3990973fe446
https://doi.org/10.1002/glia.24160

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Autor: Astrid Bottelbergs, Pablo Botella Lucena, Chritica Lodder, Bernard Hanseeuw, Niels Cremers, Hannah Vanrusselt, Tim Vanmierlo, Ilse Dewachter, Jean-Noël Octave, Isabelle Scheyltjens, Sarah Vanherle, Bert Brône, Manuel Gutiérrez de Ravé, Ilie-Cosmin Stancu, Kiavash Movahedi

Publikováno v: Acta neuropathologica communications, Vol. 9, no. 1, p. 108 [1-21] (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-21 (2021)

Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered key contributors to AD pathogenesis, their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0575ed9d7cfe6b821e4eb06ba21dec36
https://doi.org/10.1186/s40478-021-01204-8

Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

Autor: François Huaux, Ilse Dewachter, Dick Terwel, Sofie Kessels, Chritica Lodder, Ilie-Cosmin Stancu, Niels Cremers, Hannah Vanrusselt, Alexandre Vanoosthuyse, Julien Couturier, Jean-Noël Octave, Bert Brône

Publikováno v: Acta neuropathologica, Vol. 137, no. 4, p. 599-617 (2019)
Acta Neuropathologica

Brains of Alzheimer’s disease patients are characterized by the presence of amyloid plaques and neurofbrillary tangles, both invariably associated with neuroinfammation. A crucial role for NLRP3–ASC infammasome [NACHT, LRR and PYD domains-contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826f360a579ddf1c4a08a444a4d2309d
https://hdl.handle.net/2078.1/214418

Sex-regulated gene dosage effect of PPARα on synaptic plasticity

Autor: Karelle Leroy, Pascal Kienlen-Campard, Eric Bauge, Jean-Noël Octave, Philippe Gailly, Ilie-Cosmin Stancu, Donatienne Tyteca, Liza Malong, Anna Doshina, Floriane Ribeiro, Ilse Dewachter, Bart Staels, Nathalie Pierrot, Laurence Ris, Jean Pierre Brion, Olivier Schakman, Fanny Lalloyer

Publikováno v: Article
Life science alliance, 2 (2
Life science alliance, Vol. 2, no. 2, p. e201800262 [1-15] (2019)
Life Science Alliance

Mechanisms driving cognitive improvements following nuclear receptor activation are poorly understood. The peroxisome proliferator–activated nuclear receptor alpha (PPARα) forms heterodimers with the nuclear retinoid X receptor (RXR). We report th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7b76ddb12600ed3aa450a627978f99
http://hdl.handle.net/1942/30332

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

Autor: Tara L. Spires-Jones, Joseph McInnes, Keimpe D. Wierda, Ilie-Cosmin Stancu, Yu-Chun Wang, Nuno Apóstolo, Patrik Verstreken, Joris de Wit, Kris Gevaert, Lujia Zhou, Laura Bounti, Bart De Strooper, Ilse Dewachter, An Snellinx

Publikováno v: Neuron
Neuron, Vol. 97, no. 4, p. 823-835.e8 (2018)
McInnes, J, Wierda, K, Snellinx, A, Wang, Y-C, Stancu, I-C, Apostolo, N, Gevaert, K, Dewachter, I, Spires-Jones, T, De Strooper, B, De Wit, J, Zhou, L & Verstreken, P 2018, ' Synaptogyrin-3 mediates presynaptic dysfunction induced by Tau ', Neuron . https://doi.org/10.1016/j.neuron.2018.01.022

Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may be therapeutically beneficial to prevent cognitive decline and dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980b6bd02bae270864ced08fd93380f6