Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ilias Ettayebi"'
Autor:
Shengrui Feng, Sajid A. Marhon, Dustin J. Sokolowski, Alister D’Costa, Fraser Soares, Parinaz Mehdipour, Charles Ishak, Helen Loo Yau, Ilias Ettayebi, Parasvi S. Patel, Raymond Chen, Jiming Liu, Philip C. Zuzarte, King Ching Ho, Ben Ho, Shiyao Ning, Annie Huang, Cheryl H. Arrowsmith, Michael D. Wilson, Jared T. Simpson, Daniel D. De Carvalho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition (EZH
Externí odkaz:
https://doaj.org/article/0d1e7015e2c14b349eee324205203761
Autor:
Neda Stjepanovic, Amit M Oza, Anna Spreafico, Stephanie Lheureux, Marcus O Butler, Pamela S Ohashi, Kirsty Taylor, Helen Loo Yau, Ankur Chakravarthy, Ben Wang, Shu Yi Shen, Ilias Ettayebi, Charles A Ishak, Philippe L Bedard, Albiruni Abdul Razak, Aaron R Hansen, Dave Cescon, Brendan Van As, Sarah Boross-Harmer, Lisa Wang, Trevor J Pugh, Lillian L Siu, Daniel D De Carvalho
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Purpose To evaluate whether administration of the oral DNA hypomethylating agent CC-486 enhances the poor response rate of immunologically ‘cold’ solid tumors to immune checkpoint inhibitor durvalumab.Experimental design PD-L1/PD-1 inhibitor naï
Externí odkaz:
https://doaj.org/article/76a7d4cf7bd440f7a37f47994e83aedf
Autor:
Mathieu Lupien, Morag Park, Jason W. Locasale, Benjamin Haibe-Kains, Daniel D. De Carvalho, Cheryl H. Arrowsmith, David W. Cescon, Wail Ba-alawi, Hellen Kuasne, Alex Murison, Evelyne Lima-Fernandes, Paul Guilhamon, Xiaojing Liu, Alexandra N. Fedor, Paul Savage, Anne-Marie Fortier, Ilias Ettayebi, Felicia Tai, Yunchi Ingrid Kao, Constanza Martinez, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Geneviève Deblois
Supplementary data, figures and table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1f2ce65ea88c56b786929d43f46294
https://doi.org/10.1158/2159-8290.22535243
https://doi.org/10.1158/2159-8290.22535243
Autor:
Mathieu Lupien, Morag Park, Jason W. Locasale, Benjamin Haibe-Kains, Daniel D. De Carvalho, Cheryl H. Arrowsmith, David W. Cescon, Wail Ba-alawi, Hellen Kuasne, Alex Murison, Evelyne Lima-Fernandes, Paul Guilhamon, Xiaojing Liu, Alexandra N. Fedor, Paul Savage, Anne-Marie Fortier, Ilias Ettayebi, Felicia Tai, Yunchi Ingrid Kao, Constanza Martinez, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Geneviève Deblois
Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade27e1b491d653c3d380a61e2922c1e
https://doi.org/10.1158/2159-8290.c.6547796.v1
https://doi.org/10.1158/2159-8290.c.6547796.v1
Autor:
Soyoun Rachel Kim, Ilias Ettayebi, Gabrielle Trepanier, Lucy Zhao, Emily Van De Laar, Espin-Garcia Osvaldo, Aaron Pollett, Lua Eiriksson, Kathy Han, Sarah Ferguson
Publikováno v:
Featured Printed Posters (Poster Rounds with the Professors).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f77322928f4862a1ff2381009bc0b51
https://doi.org/10.1136/ijgc-2022-igcs.46
https://doi.org/10.1136/ijgc-2022-igcs.46
Autor:
Helen Loo Yau, Parinaz Mehdipour, Ilias Ettayebi, Charles A. Ishak, Ankur Chakravarthy, Daniel D. De Carvalho, Catherine A. O’Brien, Amir H. Hosseini, Fabíola Attié de Castro, Yadong Wang, Sagi Abelson, Sajid A. Marhon
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor1–6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1109453948ad13720cc00f37dbd148a6
https://doi.org/10.1038/s41586-020-2844-1
https://doi.org/10.1038/s41586-020-2844-1
Autor:
Wail Ba-alawi, Evelyne Lima-Fernandes, Jason W. Locasale, Daniel D. De Carvalho, Paul Savage, Ilias Ettayebi, Hellen Kuasne, Morag Park, Felicia Tai, Yunchi Ingrid Kao, Benjamin Haibe-Kains, Alexandra N. Fedor, Paul Guilhamon, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Cheryl H. Arrowsmith, Xiaojing Liu, Constanza Martinez, Anne-Marie Fortier, Mathieu Lupien, Alex Murison, Geneviève Deblois, David W. Cescon
Publikováno v:
Cancer Discovery. 10:1312-1329
Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f17f691a7df6fb0c70ea7fe0171046f
https://doi.org/10.1158/2159-8290.cd-19-1493
https://doi.org/10.1158/2159-8290.cd-19-1493
Publikováno v:
Cancer Research. 82:B002-B002
Viral mimicry is the induction of a cellular antiviral response triggered by endogenous nucleic acids rather than exogenous viral infection. Such nucleic acids are sensed by cytosolic pattern recognition receptors and interpreted by the cell as an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23a35067f9594ed5e39c4194573ec421
https://doi.org/10.1158/1538-7445.cancepi22-b002
https://doi.org/10.1158/1538-7445.cancepi22-b002
Publikováno v:
Trends in Cell Biology. 29:31-43
During cancer initiation and progression, the somatic epigenome is broadly reprogrammed. This reprogramming can be a consequence of several processes, including altered transcriptional profiles and mutations. In addition, immune cells infiltrating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98137c1d5ed35ce2a5a10c03770a78d5
https://doi.org/10.1016/j.tcb.2018.07.006
https://doi.org/10.1016/j.tcb.2018.07.006
Autor:
Soyoun Rachel Kim, Ilias Ettayebi, Gabrielle Trepanier, Lucy Zhao, Emily Van de Laar, Osvaldo Espin-Garcia, Aaron Pollett, Lua Eiriksson, Kathy Han, Sarah Ferguson
Publikováno v:
Gynecologic Oncology. 166:S145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8107ebb1e98934efef8f6f11d503296
https://doi.org/10.1016/s0090-8258(22)01493-7
https://doi.org/10.1016/s0090-8258(22)01493-7