Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Iliana C. Soto"'
Autor:
Vivek Singh, J. Conor Moran, Yuzuru Itoh, Iliana C. Soto, Flavia Fontanesi, Mary Couvillion, Martijn A. Huynen, Stirling Churchman, Antoni Barrientos, Alexey Amunts
In mammalian mitochondria, mRNAs are co-transcriptionally stabilized by the protein factor LRPPRC. Here, we characterize LRPPRC as an mRNA delivery factor and report its cryo-EM structure in complex with SLIRP, mRNA and the mitoribosome. The structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d736af11bd4f1dadce86e96eea4846e
https://doi.org/10.1101/2022.06.20.496763
https://doi.org/10.1101/2022.06.20.496763
Autor:
Erik McShane, Churchman Ls, Iliana C. Soto, Antoni Barrientos, Mary T. Couvillion, K. G. Hansen, Moran Jc
Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of disproportionate subunits. To determine how human cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f5c8aadb074d42623493668d44de467
https://doi.org/10.1101/2021.05.31.446345
https://doi.org/10.1101/2021.05.31.446345
Publikováno v:
Nature
Oxidative phosphorylation (OXPHOS) is fundamental for life. OXPHOS complexes pose a unique challenge for the cell, because their subunits are encoded on two different genomes, the nuclear genome and the mitochondrial genome. Genomic approaches design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be98dfabba902807e950b875dccb1a0c
https://doi.org/10.1038/nature18015
https://doi.org/10.1038/nature18015
Autor:
Antoni Barrientos, Iliana C. Soto
Publikováno v:
Antioxidants & Redox Signaling. 24:281-298
Aim: Mitochondrial cytochrome c oxidase (COX), the last enzyme of the respiratory chain, catalyzes the reduction of oxygen to water and therefore is essential for cell function and viability. COX is a multimeric complex, whose biogenesis is extensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ea5cd183823a1df48cb76fe6c54461
https://doi.org/10.1089/ars.2015.6429
https://doi.org/10.1089/ars.2015.6429
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1859:e20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61f2064b50ae953994e54c293b36190d
https://doi.org/10.1016/j.bbabio.2018.09.061
https://doi.org/10.1016/j.bbabio.2018.09.061
SUMMARY Heme plays fundamental roles as cofactor and signaling molecule in multiple pathways devoted to oxygen sensing and utilization in aerobic organisms. For cellular respiration, heme serves as a prosthetic group in electron transfer proteins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246d86d78e92e85fff43cf858611eb64
https://europepmc.org/articles/PMC3523284/
https://europepmc.org/articles/PMC3523284/
Publikováno v:
Antioxidantsredox signaling. 19(16)
Significance: Cytochrome c oxidase (COX), the last enzyme of the mitochondrial respiratory chain, is the major oxygen consumer enzyme in the cell. COX biogenesis involves several redox-regulated steps. The process is highly regulated to prevent the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad402fc06749c7b0e8a7732c92ffd90b
https://pubmed.ncbi.nlm.nih.gov/22937827
https://pubmed.ncbi.nlm.nih.gov/22937827
The intricate biogenesis of multimeric organellar enzymes of dual genetic origin entails several levels of regulation. In Saccharomyces cerevisiae, mitochondrial cytochrome c oxidase (COX) assembly is regulated translationally. Synthesis of subunit 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd32627b703a4adc43c6173f917864de
https://europepmc.org/articles/PMC2798308/
https://europepmc.org/articles/PMC2798308/