Výsledky vyhledávání - "Ilian A. Radichev"

Akademický článek

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Type 1 diabetes (T1D) is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothe

Externí odkaz: https://doaj.org/article/4cc69f69404e4a1aa049c8589a0add98

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Akademický článek

Preclinical characterization of recombinant human tissue kallikrein-1 as a novel treatment for type 2 diabetes mellitus.

Autor: Tadeusz Kolodka, Matthew L Charles, Arvind Raghavan, Ilian A Radichev, Christina Amatya, Jacob Ellefson, Alexei Y Savinov, Abhijeet Nag, Mark S Williams, Mark S Robbins

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e103981 (2014)

Modulation of the kallikrein-kinin system (KKS) has been shown to have beneficial effects on glucose homeostasis and several other physiological responses relevant to the progression of type 2 diabetes mellitus (T2D). The importance of bradykinin and

Externí odkaz: https://doaj.org/article/090dd91f92ca438b8e510dcc0b12ff60

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The Type 1 Diabetes–Resistance Locus Idd22 Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice

Autor: Mani Annamalai, Christina Amatya, John D. Glawe, Scott E. Stimpson, Clayton E. Mathews, Christopher G. Kevil, Robert L. Whitener, Jian-Wei Li, Shuyao Zhang, Sarah Knapp, Arif Yurdagul, Shuai Yuan, DongTao Fu, Vadim M. Pliner, Ilian A. Radichev, Jing Chen, Alexei Y. Savinov, Lisa Gallo Knight

Publikováno v: The Journal of Immunology. 199:3991-4000

Type 1 diabetes (T1D) has a strong genetic component. The insulin dependent diabetes (Idd)22 locus was identified in crosses of T1D-susceptible NOD mice with the strongly T1D-resistant ALR strain. The NODcALR-(D8Mit293-D8Mit137)/Mx (NOD-Idd22) recomb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fda5b0015d7aa1f008bdc2797a8c8d1
https://doi.org/10.4049/jimmunol.1602037

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Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes

Autor: Paul L. Burn, Jacob Ellefson, Maryam Salehi, Christina Amatya, Alexei Y. Savinov, Lilia Maneva-Radicheva, Ilian A. Radichev, Camille Parker

Publikováno v: The Journal of Immunology. 196:1495-1506

Ag-specific activation of T cells is an essential process in the control of effector immune responses. Defects in T cell activation, particularly in the costimulation step, have been associated with many autoimmune conditions, including type 1 diabet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6280544416559e6dc313a9c4d03dba
https://doi.org/10.4049/jimmunol.1403251

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Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2-based chimeric antigen receptor

Autor: David W. Scott, Jeongheon Yoon, Kurt J Griffin, Ilian A. Radichev, Alexei Y. Savinov

Publikováno v: Cell Immunol

Type 1 Diabetes (T1D) is an autoimmune disease marked by direct elimination of insulin-producing β cells by autoreactive T effectors. Recent T1D clinical trials utilizing autologous Tregs transfers to restore immune balance and improve disease has p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4475a9dab0dcb269f6116caf18bd4c2a
https://doi.org/10.1016/j.cellimm.2020.104224

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New insights into immunotherapy strategies for treating autoimmune diabetes

Autor: Eduardo Huarte, Miriam Araña, Miguel Barajas, Ilian A. Radichev, Miriam Cabello-Olmo, Paul Smith

Publikováno v: Academica-e: Repositorio Institucional de la Universidad Pública de Navarra
Universidad Pública de Navarra
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4789 (2019)
International Journal of Molecular Sciences
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname

Type 1 diabetes mellitus (T1D) is an autoimmune illness that affects millions of patients worldwide. The main characteristic of this disease is the destruction of pancreatic insulin-producing beta cells that occurs due to the aberrant activation of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0d74efad7ed808374e3d05e2188e2d
https://hdl.handle.net/2454/36405

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Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice

Autor: Alexei Y. Savinov, Jacob Ellefson, Mark S. Williams, Christina Amatya, Ilian A. Radichev

Type 1 diabetes (T1D) is characterized by massive destruction of insulin-producing β cells by autoreactive T lymphocytes, arising via defective immune tolerance. Therefore, effective anti-T1D therapeutics should combine autoimmunity-preventing and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab77502cc70b9ba4621c0b7337fde2b
https://europepmc.org/articles/PMC5762970/

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Nardilysin-Dependent Proteolysis of Cell-Associated VTCN1 (B7-H4) Marks Type 1 Diabetes Development

Autor: Paul L. Burn, Alexei Y. Savinov, Mark A. Atkinson, Jacob Ellefson, Camille Parker, Christina Amatya, Lilia Maneva-Radicheva, Clive Wasserfall, Ilian A. Radichev

Publikováno v: Diabetes

T-cell responses directed against insulin-secreting pancreatic β-cells are the key events highlighting type 1 diabetes (T1D). Therefore, a defective control of T-cell activation is thought to underlie T1D development. Recent studies implicated a B7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a37b65d55bf775581b4d3abcb524b5
http://europepmc.org/articles/PMC4171653

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