Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ilia V. Davydov"'
Autor:
Allan M. Weissman, Karen H. Vousden, John A. Beutler, John H. Kenten, Chou-Chi H. Li, Pankaj Oberoi, Ilia V. Davydov, Jane P. Jensen, Shervon A. Pierre, Robert L. Ludwig, Kevin L. Lorick, Yien Che Tsai, Ren-Ming Dai, Jirouta Kitagaki, Yili Yang
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in a wide range of pathologic conditions, including numer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc1227002443a3063ad1af58535618d
https://doi.org/10.1158/0008-5472.c.6496439.v1
https://doi.org/10.1158/0008-5472.c.6496439.v1
Autor:
Allan M. Weissman, Karen H. Vousden, John A. Beutler, John H. Kenten, Chou-Chi H. Li, Pankaj Oberoi, Ilia V. Davydov, Jane P. Jensen, Shervon A. Pierre, Robert L. Ludwig, Kevin L. Lorick, Yien Che Tsai, Ren-Ming Dai, Jirouta Kitagaki, Yili Yang
Supplementary Figures 1-8 from Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce062a4d872eee53295c21e6dfd6cce
https://doi.org/10.1158/0008-5472.22370567
https://doi.org/10.1158/0008-5472.22370567
Autor:
Ronggui Hu, Jai Wha Seo, Alexander Varshavsky, Ilia V. Davydov, Fangyong Du, Jee Young An, Anna Kashina, Yong Tae Kwon
Publikováno v:
Science. 297:96-99
The enzymatic conjugation of arginine to the N-termini of proteins is a part of the ubiquitin-dependent N-end rule pathway of protein degradation. In mammals, three N-terminal residues—aspartate, glutamate, and cysteine—are substrates for arginyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bcbd2d374c9266be3e3015cec0680c
https://doi.org/10.1126/science.1069531
https://doi.org/10.1126/science.1069531
Autor:
Daphne Georlette, Sarah E Wheeler, Sripriya Ranganathan, Su Wang, Galina N Nikolenko, Animesh Shukla, Thomas C Miller, Anahit Aghvanyan, Martin Stengelin, Anu Mathew, Catlin Kuklis, Deepak Sharma, Matthew Bess, Ilia V Davydov, Jacob N Wohlstadter
Publikováno v:
The Journal of Immunology. 198:61.6-61.6
Most immunoassays quantify cytokines with pg/mL sensitivity, which is insufficient to detect those present at low levels. MSD’s next-generation S-PLEXSM assay format was developed to quantify cytokines with fg/mL sensitivity. Here we describe measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::609a5fcecd420c1151ab138f6d13f91a
https://doi.org/10.4049/jimmunol.198.supp.61.6
https://doi.org/10.4049/jimmunol.198.supp.61.6
Autor:
Victoria Yatsula, Christopher Shelburne, Qian Ning, Priscilla Krai, David Cheo, Sripriya Ranganathan, Ilia V. Davydov, Pu Liu, David Stewart, Pankaj Oberoi, James Wilbur, Jacob N. Wohlstadter
Publikováno v:
The Journal of Immunology. 198:81.18-81.18
In the expanding field of biomarker research, methods to identify immunoassay reagents and optimize their use can be rate limiting for product development programs. Flexible tools that accelerate assay development, from antibody screening and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b4989baebca870eafa98ed80102f85
https://doi.org/10.4049/jimmunol.198.supp.81.18
https://doi.org/10.4049/jimmunol.198.supp.81.18
Autor:
Alexander Varshavsky, Ilia V. Davydov, Victor H. Denenberg, Lynn A. Hyde, Yong Tae Kwon, Youming Xie, Anna Kashina, Arti Gaur, Jeong Kyo Yoon, Seth A. Balogh
Publikováno v:
Molecular and Cellular Biology. 20:4135-4148
A multitude of regulatory circuits involve conditionally or constitutively short-lived proteins (26, 27, 44, 48, 49, 64). Features of proteins that confer metabolic instability are called degradation signals, or degrons (37, 63). The essential compon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8b99bf61a7d96bce368950b513a93f
https://doi.org/10.1128/mcb.20.11.4135-4148.2000
https://doi.org/10.1128/mcb.20.11.4135-4148.2000
Publikováno v:
Archives of Biochemistry and Biophysics. 357:317-325
Ubiquitin-dependent degradation of intracellular proteins underlies a multitude of biological processes, including the cell cycle, cell differentiation, and responses to stress. One ubiquitin-dependent proteolytic system is the N-end rule pathway, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a068726571cf49e88ed08422064dcf94
https://doi.org/10.1006/abbi.1998.0829
https://doi.org/10.1006/abbi.1998.0829
Autor:
Ilia V. Davydov, Jianmin Zhou, Ronggui Hu, Haiqing Wang, Alexander Varshavsky, Yong Tae Kwon, Jun Sheng, Christopher S. Brower
Publikováno v:
The Journal of biological chemistry. 281(43)
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853bf4c47010d9e33b05890bd3516422
https://pubmed.ncbi.nlm.nih.gov/16943202
https://pubmed.ncbi.nlm.nih.gov/16943202
Autor:
Ilia V, Davydov, John H, Kenten, Yassamin J, Safiran, Stefanie, Nelson, Ryan, Swenerton, Pankaj, Oberoi, Hans A, Biebuyck
Publikováno v:
Methods in enzymology. 399
We describe a systematic, high-throughput approach to the discovery of protein substrates of ubiquitylation. This method uses a library of cDNAs in combination with a reticulocyte lysate-based, transcription-translation system that acts as both an ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::813bc5a44d6374f2f32352d3b0fd4dbb
https://pubmed.ncbi.nlm.nih.gov/16338373
https://pubmed.ncbi.nlm.nih.gov/16338373
Autor:
John H, Kenten, Ilia V, Davydov, Yassamin J, Safiran, David H, Stewart, Pankaj, Oberoi, Hans A, Biebuyck
Publikováno v:
Methods in enzymology. 399
We developed a series of assays for biochemical activities involving ubiquitin. These assays use electrochemiluminescence detection to measure the ubiquitylation of target proteins. To enable electrochemiluminescence detection, the target proteins we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9061fd32fc472e5bb0e4928e8463174c
https://pubmed.ncbi.nlm.nih.gov/16338389
https://pubmed.ncbi.nlm.nih.gov/16338389