PDT-Induced Variations of Radachlorin Fluorescence Lifetime in Living Cells In Vitro

Autor: Andrey V. Belashov, Anna A. Zhikhoreva, Anna V. Salova, Tatiana N. Belyaeva, Ilia K. Litvinov, Elena S. Kornilova, Irina V. Semenova

Publikováno v: Photonics, Vol 10, Iss 11, p 1262 (2023)

Variations in the fluorescence lifetimes of Radachlorin photosensitizers in HeLa and A549 cells, caused by photodynamic treatment, were studied using fluorescence lifetime imaging microscopy (FLIM). An analysis of FLIM images of the cells demonstrate

Externí odkaz: https://doaj.org/article/99fd3051f105492b873d76e3ab040548

Deep generative design of RNA aptamers using structural predictions.

Autor: Wong F; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Integrated Biosciences, Redwood City, CA, USA., He D; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.; Shanghai Artificial Intelligence Laboratory, Shanghai, China., Krishnan A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Hong L; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China., Wang AZ; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Wang J; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China., Hu Z; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China., Omori S; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Integrated Biosciences, Redwood City, CA, USA., Li A; Integrated Biosciences, Redwood City, CA, USA., Rao J; School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China., Yu Q; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China., Jin W; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA., Zhang T; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Ilia K; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Chen JX; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Zheng S; Global Institute of Future Technology, Shanghai Jiao Tong University, Shanghai, China., King I; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China., Li Y; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. liyu@cse.cuhk.edu.hk.; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. liyu@cse.cuhk.edu.hk.; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China. liyu@cse.cuhk.edu.hk.; The CUHK Shenzhen Research Institute, Shenzhen, China. liyu@cse.cuhk.edu.hk.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. liyu@cse.cuhk.edu.hk., Collins JJ; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. jimjc@mit.edu.; Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. jimjc@mit.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. jimjc@mit.edu.

Publikováno v: Nature computational science [Nat Comput Sci] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.

Biocompatible Ir(III) Complexes as Oxygen Sensors for Phosphorescence Lifetime Imaging

Autor: Ilya S. Kritchenkov, Anastasia I. Solomatina, Daria O. Kozina, Vitaly V. Porsev, Victor V. Sokolov, Marina V. Shirmanova, Maria M. Lukina, Anastasia D. Komarova, Vladislav I. Shcheslavskiy, Tatiana N. Belyaeva, Ilia K. Litvinov, Anna V. Salova, Elena S. Kornilova, Daniel V. Kachkin, Sergey P. Tunik

Publikováno v: Molecules, Vol 26, Iss 10, p 2898 (2021)

Synthesis of biocompatible near infrared phosphorescent complexes and their application in bioimaging as triplet oxygen sensors in live systems are still challenging areas of organometallic chemistry. We have designed and synthetized four novel iridi

Externí odkaz: https://doaj.org/article/a3f99b75df2842078455f27c446fe172

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.

Autor: Ilia K; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Shakiba N; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z3 Canada., Bingham T; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.; Harvard University, Boston, MA 02115, USA., Jones RD; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z3 Canada., Kaminski MM; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz-Association, Berlin 10115, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Medizinische Klinik m.S. Nephrologie und Intensivmedizin, Berlin 10117, Germany.; Berlin Institute of Health, Berlin 13125, Germany., Aravera E; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY 11794, USA., Bruno S; Department of Mechanical Engineering, MIT, Cambridge, MA 02139, USA., Palacios S; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Mechanical Engineering, MIT, Cambridge, MA 02139, USA.; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA., Weiss R; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA., Collins JJ; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Del Vecchio D; Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Mechanical Engineering, MIT, Cambridge, MA 02139, USA., Schlaeger TM; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA.

Publikováno v: Science advances [Sci Adv] 2023 Dec; Vol. 9 (48), pp. eadg8495. Date of Electronic Publication: 2023 Nov 29.

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