Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Ilia G, Denisov"'
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 853 (2022)
Human cytochrome P450 CYP3A4 is involved in the processing of more than 35% of current pharmaceuticals and therefore is responsible for multiple drug-drug interactions (DDI). In order to develop a method for the detection and prediction of the possib
Externí odkaz:
https://doaj.org/article/92e5ee7a233646d9a727dfab2e651c8d
Autor:
Ilia G. Denisov, Stephen G. Sligar, Michael C. Gregory, Yilin Liu, Yelena V. Grinkova, James R. Kincaid
Publikováno v:
Biochemistry
Steroid metabolism in humans originates from cholesterol and involves several enzyme reactions including dehydrogenation, hydroxylation, and carbon–carbon bond cleavage that occur at regio- and stereo-specific points in the four-membered ring struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547aff033426072361c5f67408b05fc8
https://doi.org/10.1021/acs.biochem.1c00282
https://doi.org/10.1021/acs.biochem.1c00282
Publikováno v:
Biochemistry
We developed an efficient and sensitive probe for drug–drug interactions mediated by human CYP3A4 by using midazolam (MDZ) as a probe substrate. Using global analysis of four parameters over several experimental data sets, we demonstrate that the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b142bed1837d74f3c50c9c8445b8313a
https://doi.org/10.1021/acs.biochem.1c00161
https://doi.org/10.1021/acs.biochem.1c00161
Publikováno v:
Metabolites, Vol 9, Iss 8, p 158 (2019)
Enniatins (ENNs) are fungal secondary metabolites that frequently occur in grain in temperate climates. Their toxic potency is connected to their ionophoric character and lipophilicity. The biotransformation of ENNs predominantly takes place via cyto
Externí odkaz:
https://doaj.org/article/e87005015b614209842a6d1a5a3e5d18
Autor:
Ilia G. Denisov, Stephen G. Sligar
Publikováno v:
Journal of Inorganic Biochemistry. 243:112202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4f63d6fd39189baf5bfe0ea0a2c9ec9
https://doi.org/10.1016/j.jinorgbio.2023.112202
https://doi.org/10.1016/j.jinorgbio.2023.112202
Publikováno v:
Journal of the American Chemical Society. 143:3729-3733
CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. The second reaction is the C17-C20 bond scission,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8462e442bcfd02bf69d7041f5a988dd
https://doi.org/10.1021/jacs.1c00581
https://doi.org/10.1021/jacs.1c00581
Publikováno v:
Chemistry
Human cytochrome P450 CYP17A1 first catalyzes hydroxylation at the C17 position of either pregnenolone (PREG) or progesterone (PROG), and a subsequent C(17)–C(20) bond scission to produce dehydroepiandrosterone (DHEA) or androstenedione (AD). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfdf31d6d0dc3faed356d25c2afbe6b
https://doi.org/10.1002/chem.202003181
https://doi.org/10.1002/chem.202003181
When subjected to γ-irradiation at cryogenic temperatures the oxygenated complexes of Cytochrome P450 17A1 bound with either of the lyase substrates, 17-OH PREG or 17-OH PROG are shown here to generate the corresponding lyase products, dehydroepiand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baa49eb280ea94755f58fbc5a0f5ed4f
https://doi.org/10.33774/chemrxiv-2021-r67s4
https://doi.org/10.33774/chemrxiv-2021-r67s4
Publikováno v:
J Am Chem Soc
CYP17A1 is an essential human steroidogenic enzyme, which catalyzes two sequential reactions leading to the formation of androstenedione from progesterone and dehydroepiandrosterone from pregnenolone. The second reaction is the C17-C20 bond scission,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2648632e5b632dd56090bd4fb315a4f
https://pubmed.ncbi.nlm.nih.gov/33656879
https://pubmed.ncbi.nlm.nih.gov/33656879
Autor:
Stephen G. Sligar, Ilia G. Denisov
Publikováno v:
Protein Sci
Membrane proteins are involved in numerous vital biological processes, including transport, signal transduction and the enzymes in a variety of metabolic pathways. Integral membrane proteins account for up to 30% of the human proteome and they make u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e973783ab9c6919d90842923161101d
https://pubmed.ncbi.nlm.nih.gov/33165998
https://pubmed.ncbi.nlm.nih.gov/33165998