Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ilga K. Krimmelbein"'
Autor:
Wenxi Lei, Anke Deckers, Charlotte Luchena, Anna Popova, Markus Reischl, Nicole Jung, Stefan Bräse, Thomas Schwartz, Ilga K. Krimmelbein, Lutz F. Tietze, Pavel A. Levkin
Publikováno v:
Advanced Biology, 6 (12), Art.-Nr.: 2200166
Multidrug-resistant (MDR) bacteria is a severe threat to public health. Therefore, it is urgent to establish effective screening systems for identifying novel antibacterial compounds. In this study, a highly miniaturized droplet microarray (DMA) base
Publikováno v:
Synthesis. 2009:2040-2060
A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey―Fuchs reaction, elimination, and Sonogashira reaction.
Autor:
Carsten A. Vock, Ilga K. Krimmelbein, Christiane Gatz, Kazi Mohammed Didarul Islam, J. Matthias Wiegand, Linda Nacke, Lutz F. Tietze, Tokala Ramachandar
Publikováno v:
Chemistry - A European Journal. 14:3670-3679
A library of 17 novel estrogen analogues 3 and 4 containing different substituents at rings A and D (steroid nomenclature) was prepared in a five- to seven-step synthesis. The key transformation is a Sonogashira-coupling of cyclic vinyl iodides of ty
Publikováno v:
ChemInform. 40
Autor:
Lutz F. Tietze, Ilga K. Krimmelbein, Kazi Mohammed Didarul Islam, Carsten A. Vock, Meik Dilcher, Christiane Gatz, Huimin Zhao, Victor Hugo Gonzalez, Corinna Thurow
Publikováno v:
Protein engineering, designselection : PEDS. 22(1)
Transcriptional activators that respond to ligands with nocellular targets are powerful tools that can confer regu-lated expression of a transgene in almost all biologicalsystems. In this study, we altered the ligand-bindingspecificity of the human
Autor:
Tokala Ramachandar, Kazi Mohammed Didarul Islam, Christiane Gatz, Lutz F. Tietze, Linda Nacke, Carsten A. Vock, J. Matthias Wiegand, Ilga K. Krimmelbein
Publikováno v:
ChemInform. 39
A library of 17 novel estrogen analogues 3 and 4 containing different substituents at rings A and D (steroid nomenclature) was prepared in a five- to seven-step synthesis. The key transformation is a Sonogashira-coupling of cyclic vinyl iodides of ty
Autor:
Lutz F. Tietze, Ilga K. Krimmelbein
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 14(5)
A novel enantioselective total synthesis of the oral contraceptive desogestrel (2) is described, in which the tetracyclic steroid core is formed by a sequence of two consecutive Heck reactions. Conversion of the known enantiopure diketone 7 led to th