TGF-β1 induces formation of TSG-6-enriched extracellular vesicles in fibroblasts which can prevent myofibroblast transformation by modulating Erk1/2 phosphorylation.

Autor: Ilg MM; Medical Technology Research Centre, HEMS, SoAH, Anglia Ruskin University, Chelmsford, CM1 1SQ, UK., Bustin SA; Medical Technology Research Centre, HEMS, SoAH, Anglia Ruskin University, Chelmsford, CM1 1SQ, UK., Ralph DJ; Medical Technology Research Centre, HEMS, SoAH, Anglia Ruskin University, Chelmsford, CM1 1SQ, UK.; Urology Department, University College London, London, UK., Cellek S; Medical Technology Research Centre, HEMS, SoAH, Anglia Ruskin University, Chelmsford, CM1 1SQ, UK. selim.cellek@aru.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2024 May 29; Vol. 14 (1), pp. 12389. Date of Electronic Publication: 2024 May 29.

Hydroxypyridone anti-fungals selectively induce myofibroblast apoptosis in an in vitro model of hypertrophic scars.

Autor: Lapthorn AR; Fibrosis Research Group, Medical Technology Research Centre, School of Allied Health, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK. Electronic address: alice.lapthorn@aru.ac.uk., Ilg MM; Fibrosis Research Group, Medical Technology Research Centre, School of Allied Health, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK., Dziewulski P; Fibrosis Research Group, Medical Technology Research Centre, School of Allied Health, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK; St. Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, UK; St Andrew's Anglia Ruskin Research Group (StAAR), Chelmsford, UK., Cellek S; Fibrosis Research Group, Medical Technology Research Centre, School of Allied Health, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 Mar 15; Vol. 967, pp. 176369. Date of Electronic Publication: 2024 Feb 05.

A combination of phosphodiesterase type 5 inhibitor and tamoxifen for acute Peyronie's disease: the first clinical signals.

Autor: Cellek S; Fibrosis Research Group, Medical Technology Research Centre, Anglia Ruskin University, Chelmsford CM1 1SQ, United Kingdom., Megson M; Fibrosis Research Group, Medical Technology Research Centre, Anglia Ruskin University, Chelmsford CM1 1SQ, United Kingdom.; Urology Department, University College London Hospital, London W1G 8PH, United Kingdom., Ilg MM; Fibrosis Research Group, Medical Technology Research Centre, Anglia Ruskin University, Chelmsford CM1 1SQ, United Kingdom., Ralph DJ; Fibrosis Research Group, Medical Technology Research Centre, Anglia Ruskin University, Chelmsford CM1 1SQ, United Kingdom.; Urology Department, University College London Hospital, London W1G 8PH, United Kingdom.

Publikováno v: The journal of sexual medicine [J Sex Med] 2023 Jul 31; Vol. 20 (8), pp. 1057-1059.

Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars.

Autor: Lapthorn AR; Medical Technology Research Centre, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK. Electronic address: alice.lapthorn@aru.ac.uk., Ilg MM; Medical Technology Research Centre, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK., Sullivan JV; St. Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, UK., Dziewulski P; Medical Technology Research Centre, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK; St. Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, UK; St Andrew's Anglia Ruskin Research Group (StAAR), Chelmsford, UK., Cellek S; Medical Technology Research Centre, School of Allied Health, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford, UK.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2022 Dec 15; Vol. 937, pp. 175374. Date of Electronic Publication: 2022 Nov 05.

Phosphodiesterase Type 5 Inhibitors and Selective Estrogen Receptor Modulators Can Prevent But Not Reverse Myofibroblast Transformation in Peyronie's Disease.

Autor: Ilg MM; Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, Essex, UK. Electronic address: marcus.ilg@anglia.ac.uk., Stafford SJ; Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, Essex, UK., Mateus M; Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, Essex, UK., Bustin SA; Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, Essex, UK., Carpenter MJ; Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, Essex, UK., Muneer A; Department of Urology, University College London, London, UK; NIHR Biomedical Research Centre, University College London, London, UK., Bivalacqua TJ; James Buchanan Brady Urologic Institute, John Hopkins University, Baltimore, MD, USA., Ralph DJ; Department of Urology, University College London, London, UK., Cellek S; Medical Technology Research Centre, Anglia Ruskin University, Chelmsford, Essex, UK.

Publikováno v: The journal of sexual medicine [J Sex Med] 2020 Oct; Vol. 17 (10), pp. 1848-1864. Date of Electronic Publication: 2020 Aug 05.