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High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding.

Autor: Ilgü, Hüseyin¹ (AUTHOR), Jeckelmann, Jean-Marc¹ (AUTHOR), Kalbermatter, David¹ (AUTHOR), Ucurum, Zöhre¹ (AUTHOR), Lemmin, Thomas^2,3 (AUTHOR) thomas.lemmin@inf.ethz.ch, Fotiadis, Dimitrios¹ (AUTHOR) dimitrios.fotiadis@ibmm.unibe.ch

Publikováno v: BMC Biology. 8/30/2021, Vol. 19 Issue 1, p1-13. 13p.

A procedure and double-chambered device for macromolecular crystal flash-cooling in different cryogenic liquids.

Autor: Jeckelmann, Jean-Marc¹ (AUTHOR) jean-marc.jeckelmann@ibmm.unibe.ch, Ilgü, Hüseyin¹ (AUTHOR), Bosshart, Patrick D.¹ (AUTHOR), Fotiadis, Dimitrios¹ (AUTHOR)

Publikováno v: PLoS ONE. 9/25/2020, Vol. 15 Issue 9, p1-9. 9p.

Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor

Autor: Stauffer, Mirko, Jeckelmann, Jean-Marc, Ilgü, Hüseyin, Ucurum, Zöhre, Boggavarapu, Rajendra, Fotiadis, Dimitrios

Publikováno v: Stauffer, Mirko; Jeckelmann, Jean-Marc; Ilgü, Hüseyin; Ucurum, Zöhre; Boggavarapu, Rajendra; Fotiadis, Dimitrios (2022). Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor. Communications chemistry, 5(1) Springer Nature 10.1038/s42004-022-00636-0

Inhibitors for membrane transporters have been shown to be indispensable as drugs and tool compounds. The proton-dependent oligopeptide transporters PEPT1 and PEPT2 from the SLC15 family play important roles in human and mammalian physiology. With Ly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fb3682ff914d466115caea5cceb033

Additional file 1 of High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding

Autor: Ilgü, Hüseyin, Jeckelmann, Jean-Marc, Kalbermatter, David, Ucurum, Zöhre, Lemmin, Thomas, Fotiadis, Dimitrios

Additional file 1: Supplementary Figures and Tables. Fig. S1. Schematic representation of the alternating access mechanism. The major conformational changes and states of the transporter are shown, which are necessary to allow alternating substrate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a28de0fb0063ae1be0bb770acf0bea0