Výsledky vyhledávání - "Ilene D Kurzman"

Akademický článek

Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting.

Autor: Kara Magee, Ian R Marsh, Michelle M Turek, Joseph Grudzinski, Eduardo Aluicio-Sarduy, Jonathan W Engle, Ilene D Kurzman, Cindy L Zuleger, Elizabeth A Oseid, Christine Jaskowiak, Mark R Albertini, Karla Esbona, Bryan Bednarz, Paul M Sondel, Jamey P Weichert, Zachary S Morris, Reinier Hernandez, David M Vail

Publikováno v: PLoS ONE, Vol 16, Iss 8, p e0255798 (2021)

RationaleMurine syngeneic tumor models have revealed efficacious systemic antitumor responses following primary tumor in situ vaccination combined with targeted radionuclide therapy to secondary or metastatic tumors. Here we present studies on the sa

Externí odkaz: https://doaj.org/article/614577853cda400990756e8aa63b13c4

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Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting

Autor: Joseph Grudzinski, Bryan Bednarz, Eduardo Aluicio-Sarduy, Zachary S. Morris, Karla Esbona, Elizabeth A Oseid, Mark R. Albertini, Ian Marsh, Christine Jaskowiak, Jonathan W. Engle, Kara Magee, David M. Vail, Reinier Hernandez, Paul M. Sondel, Ilene D. Kurzman, Michelle Turek, Cindy L. Zuleger, Jamey P. Weichert

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0255798 (2021)

Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor responses following primary tumor in situ vaccination combined with targeted radionuclide therapy to secondary or metastatic tumors. Here we present studies on the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac76fe71d2091e50f7d91c2faaee5154
http://europepmc.org/articles/PMC8360580

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Pilot study of safety and feasibility of DNA microseeding for treatment of spontaneous canine melanoma

Autor: Michael A. Newton, Cindy L. Zuleger, Ilene D. Kurzman, Michael D. Macklin, Chulhi Kang, Mark R. Albertini, Elof Eriksson, Jedd D. Wolchok, Erik A. Ranheim, David M. Vail

Publikováno v: Veterinary Medicine and Science

Spontaneous canine malignant melanoma provides an excellent pre‐clinical model to study DNA vaccines for melanoma immunotherapy. A USDA‐approved xenogeneic human tyrosinase (huTYR) plasmid DNA vaccine delivered intramuscularly induces detectable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0de4bf77b124208cb6c6bc2921d157
https://pubmed.ncbi.nlm.nih.gov/29067210

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Neurokinin-1 receptor expression and antagonism by the NK-1R antagonist maropitant in canine melanoma cell lines and primary tumour tissues

Autor: S. A. K. Miller, Juan Borrego, M. E. Pinkerton, J. L. Muszynski, David M. Vail, M. K. Huelsmeyer, Ilene D. Kurzman

Publikováno v: Veterinary and Comparative Oncology. 14:210-224

We interrogated the neurokinin-1 receptor (NK-1R)/substance P (SP) pathway in canine melanoma tumour tissues and cell lines. NK-1R messenger RNA (mRNA) and protein expression were observed in the majority of tumour tissues. Immunohistochemical assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0986973dd246a43e7b5a9b8091bab649
https://doi.org/10.1111/vco.12093

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Safety evaluation of combination CCNU and continuous toceranib phosphate (Palladia®) in tumour-bearing dogs: a phase I dose-finding study

Autor: K. Tsimbas, Xuan Pan, Ilene D. Kurzman, David M. Vail

Publikováno v: Veterinary and Comparative Oncology. 14:202-209

While maintaining a standard toceranib dosage [2.75 mg kg−1, PO, every other day (EOD)], three dose-escalating CCNU cohorts up to and including 60 mg m−2, PO, q3wk, were completed. The dose-limiting toxicities (DLT) for the combination were neutr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::972c8d6e3cbccb9ff1e199b67cc4cae8
https://doi.org/10.1111/vco.12091

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Novel acyclic nucleotide analogues GS-343074 and GS-424044 demonstrate antiproliferative and pro-apoptotic activity in canine neoplastic cell lines

Autor: Jessica Lawrence, Douglas H. Thamm, M. K. Huelsmeyer, Ilene D. Kurzman, David M. Vail, Gabriel Birkus, Daniel B. Tumas

Publikováno v: Veterinary and Comparative Oncology. 13:246-254

GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG) has significant activity as monotherapy in dogs with non-Hodgkin's lymphoma. Phase I trials have been initiated in humans based on the encouraging activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::affe7f943f41f5090e761a7cc98122c4
https://doi.org/10.1111/vco.12038

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Phase I Study to Determine the Maximal Tolerated Dose and Dose-Limiting Toxicities of Orally Administered Idarubicin in Dogs with Lymphoma

Autor: A. McDonnell, Brian D. Husbands, H. Simpson, Ilene D. Kurzman, S.G. Kamerling, David M. Vail

Publikováno v: Journal of Veterinary Internal Medicine. 26:608-613

Background Idarubicin, a PO bioavailable anthracycline antibiotic-class chemotherapeutic, could have substantial convenience advantages over currently available similar class agents in use that require IV delivery. Objectives The primary objective of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dcf88f38cb7d5a259ab7bb0f7ecdc8
https://doi.org/10.1111/j.1939-1676.2012.00896.x

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Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor

Autor: Steven Susaneck, Monika K. Jankowski, Paul R. Hess, Mary K. Klein, Jedd D. Wolchok, Philip J. Bergman, Ilene D. Kurzman, Pamela D Jones, Deborah A. Grosenbaugh, Maribeth H. Johnson, A. Timothy Leard, Nicole F. Leibman, Karri Meleo

Publikováno v: American Journal of Veterinary Research. 72:1631-1638

Objective—To evaluate the safety and efficacy of a vaccine containing plasmid DNA with an insert encoding human tyrosinase (ie, huTyr vaccine) as adjunctive treatment for oral malignant melanoma (MM) in dogs. Animals—111 dogs (58 prospectively en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b3f7fcb8a54738fca9fafcc92d6e5c
https://doi.org/10.2460/ajvr.72.12.1631

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Preclinical Investigation of PEGylated Tumor Necrosis Factor α in Dogs with Spontaneous Tumors: Phase I Evaluation

Autor: Ilene D. Kurzman, Douglas H. Thamm, David M. Vail, Daniel L. Gustafson, Mike A. Clark, E. J. Ehrhart, Susan L. Kraft

Publikováno v: Clinical Cancer Research. 16:1498-1508

Purpose: Tumor necrosis factor-α (TNF) is a cytokine with potent antitumor activity; however, toxicity and short half-life have limited its utility. Polyethylene glycol (PEG) conjugation of biotherapeutics can decrease immunogenicity while improving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a847effcb648cc2e9b67bb0204d8bc
https://doi.org/10.1158/1078-0432.ccr-09-2804

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