Výsledky vyhledávání - "Ileana R. León"

Quantitative Assessment of In-solution Digestion Efficiency Identifies Optimal Protocols for Unbiased Protein Analysis

Autor: Ole N. Jensen, Ileana R. León, Richard R. Sprenger, Veit Schwämmle

Publikováno v: Molecular & Cellular Proteomics. 12:2992-3005

The majority of mass spectrometry-based protein quantification studies uses peptide-centric analytical methods and thus strongly relies on efficient and unbiased protein digestion protocols for sample preparation. We present a novel objective approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8270f20d54b40ca794e75c10e8acb7ce
https://doi.org/10.1074/mcp.m112.025585

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Tissue Specific Phosphorylation of Mitochondrial Proteins Isolated from Rat Liver, Heart Muscle, and Skeletal Muscle

Autor: Ileana R. León, Steffen Bak, Ole N. Jensen, Kurt Højlund

Publikováno v: Bak, S, León, I R, Jensen, O N & Højlund, K 2013, ' Tissue specific phosphorylation of mitochondrial proteins isolated from rat liver, heart muscle, and skeletal muscle ', Journal of Proteome Research, vol. 12, no. 10, pp. 4327-4339 . https://doi.org/10.1021/pr400281r

Phosphorylation of mitochondrial proteins in a variety of biological processes is increasingly being recognized and may contribute to the differences in function and energy demands observed in mitochondria from different tissues such as liver, heart,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7441259213de7760f00063f6294a34
https://doi.org/10.1021/pr400281r

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Moving Pieces in a Venomic Puzzle: Unveiling Post-translationally Modified Toxins from Tityus serrulatus

Autor: Ileana R. León, Frank Kjeldsen, Adriano Marçal Pimenta, Marcella Nunes Melo-Braga, Alexandre A. A. Dutra, Thiago Verano-Braga, Peter Roepstorff

Publikováno v: Verano-Braga, T, Dutra, A A A, León, I R, Melo-Braga, M N, Roepstorff, P, Pimenta, A M C & Kjeldsen, F 2013, ' Moving pieces in a venomic puzzle : unveiling post-translationally modified toxins from Tityus serrulatus ', Journal of Proteome Research, vol. 12, no. 7, pp. 3460-3470 . https://doi.org/10.1021/pr4003068

Besides being a public health problem, scorpion venoms have a potential biotechnological application since they contain peptides that may be used as drug leads and/or to reveal novel pharmacological targets. A comprehensive Tityus serrulatus venom pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a42236d906f3dd0ebeed1b90fb39f73
https://doi.org/10.1021/pr4003068

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Proteomics identifies molecular networks affected by tetradecylthioacetic acid and fish oil supplemented diets

Autor: Ole N. Jensen, Ileana R. León, Krzysztof Wrzesinski, Adelina Rogowska-Wrzesinska, Richard R. Sprenger, Bodil Bjørndal, Rolf K. Berge, Katarzyna Kulej, Bjørn Jostein Christensen

Publikováno v: Wrzesinski, K, León, I R, Kulej, K, Sprenger, R R, Bjørdal, B, Christiansen, BJ, Berge, R K, Jensen, O N & Rogowska-Wrzesinska, A 2013, ' Proteomics identifies molecular networks affected by tetradecylthioacetic acid and fish oil supplemented diets ', Journal of Proteomics, vol. 84, pp. 61-77 . https://doi.org/10.1016/j.jprot.2013.03.027

Fish oil (FO) and tetradecylthioacetic acid (TTA) — a synthetic modified fatty acid have beneficial effects in regulating lipid metabolism. In order to dissect the mechanisms underlying the molecular action of those two fatty acids we have investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce107eb0c7ff44dde032564d8d2404c
https://doi.org/10.1016/j.jprot.2013.03.027

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Using mass spectrometry to explore the neglected glycan moieties of the antiophidic proteins DM43 and DM64

Autor: Richard H. Valente, Monique R.O. Trugilho, Surza Lucia Gonçalves da Rocha, Jonas Perales, Ileana R. León, Ana G.C. Neves-Ferreira

Publikováno v: PROTEOMICS. 12:2753-2765

The resistance of the opossum Didelphis aurita to Bothrops snake venoms is attributed to the opossum's antihemorrhagic (DM43) and antimyotoxic (DM64) acidic serum glycoproteins. The aim of this study was to characterize the N-glycosylation sites of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622c4300a3cce168ad6668716a6c5765
https://doi.org/10.1002/pmic.201200062

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Crotalid Snake Venom Subproteomes Unraveled by the Antiophidic Protein DM43

Autor: Ana G.C. Neves-Ferreira, Ileana R. León, Jonas Perales, Surza Lucia Gonçalves da Rocha, Alex Chapeaurouge, Richard H. Valente, Gilberto B. Domont, Monique R.O. Trugilho

Publikováno v: Journal of Proteome Research. 8:2351-2360

Snake venoms are mixtures of proteins and peptides with different biological activities, many of which are very toxic. Several animals, including the opossum Didelphis aurita, are resistant to snake venoms due to the presence of neutralizing factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74039dad32a8ab0c256c3c0c2a6304b1
https://doi.org/10.1021/pr800977s

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Improved protein identification efficiency by mass spectrometry usingN-terminal chemical derivatization of peptides fromAngiostrongylus costaricensis, a nematode with unknown genome

Autor: Henrique Leonel Lenzi, Richard H. Valente, Ester Maria Mota, Ana G.C. Neves-Ferreira, Jonas Perales, Ileana R. León

Publikováno v: Journal of Mass Spectrometry. 42:781-792

Matrix-assisted laser desorption ionization (MALDI), Peptide Mass Fingerprinting (PMF) and MALDI-MS/MS ion search (using MASCOT) have become the preferred methods for high-throughput identification of proteins. Unfortunately, PMF can be ambiguous, ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d2be427f7b6eda97dd5b0348d5516
https://doi.org/10.1002/jms.1214

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Antibodies from dogs with canine visceral leishmaniasis recognise two proteins from the saliva of Lutzomyia longipalpis

Autor: Ileana R. León, Marcos H. Pereira, Jonas Perales, Guilherme Oliveira, Alexandre Barbosa Reis, Nelder F. Gontijo, Diana Bahia, Rodrigo Correa-Oliveira

Publikováno v: Parasitology Research. 100:449-454

The saliva of the sand fly Lutzomyia longipalpis, a major vector of Leishmania, exhibits pharmacological and immunomodulatory activities that may facilitate entry and establishment of parasites into the vertebrate host. Salivary gland components of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc504b96fd7fc4b48b26b4b5beb2ad3
https://doi.org/10.1007/s00436-006-0307-8

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Assessment and improvement of statistical tools for comparative proteomics analysis of sparse data sets with few experimental replicates

Autor: Ole N. Jensen, Ileana R. León, Veit Schwämmle

Publikováno v: Schwämmle, V, León, I R & Jensen, O N 2013, ' Assessment and improvement of statistical tools for comparative proteomics analysis of sparse data sets with few experimental replicates ', Journal of Proteome Research, vol. 12, no. 9, pp. 3874-3883 . https://doi.org/10.1021/pr400045u

Large-scale quantitative analyses of biological systems are often performed with few replicate experiments, leading to multiple nonidentical data sets due to missing values. For example, mass spectrometry driven proteomics experiments are frequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae16a3158fd01eaff021e3c106a2529
https://pubmed.ncbi.nlm.nih.gov/23875961

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