Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ileana, Lorenzini"'
Autor:
Cécilia Tremblay, Sidra Aslam, Jessica E. Walker, Ileana Lorenzini, Anthony J. Intorcia, Richard A. Arce, Parichita Choudhury, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal Mehta, Ignazio S. Piras, Christine M. Belden, Alireza Atri, Thomas G. Beach, Geidy E. Serrano
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106514- (2024)
The olfactory bulb is involved early in the pathophysiology of Parkinson's disease (PD), which is consistent with the early onset of olfactory dysfunction. Identifying the molecular mechanisms through which PD affects the olfactory bulb could lead to
Externí odkaz:
https://doaj.org/article/92c40a472abb4d38a754034d735dbb6d
Autor:
Ileana Lorenzini, Eric Alsop, Jennifer Levy, Lauren M. Gittings, Deepti Lall, Benjamin E. Rabichow, Stephen Moore, Ryan Pevey, Lynette M. Bustos, Camelia Burciu, Divya Bhatia, Mo Singer, Justin Saul, Amanda McQuade, Makis Tzioras, Thomas A. Mota, Amber Logemann, Jamie Rose, Sandra Almeida, Fen-Biao Gao, Michael Marks, Christopher J. Donnelly, Elizabeth Hutchins, Shu-Ting Hung, Justin Ichida, Robert Bowser, Tara Spires-Jones, Mathew Blurton-Jones, Tania F. Gendron, Robert H. Baloh, Kendall Van Keuren-Jensen, Rita Sattler
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal cells induce or exacerbate neuronal damage. We differentiated C9orf72 ALS
Externí odkaz:
https://doaj.org/article/c5861f14d9984d6d91846ead3941a04a
Autor:
Cécilia Tremblay, Parichita Choudhury, Christine M. Belden, Danielle Goldfarb, Ileana Lorenzini, Thomas G. Beach, Geidy E. Serrano
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionSex differences in Alzheimer’s disease (AD) may contribute to disease heterogeneity and affect prevalence, risk factors, disease trajectories and outcomes. Depression impacts a large number of patients with AD and has been reported to b
Externí odkaz:
https://doaj.org/article/c381fa7ee0914a65b8e375bf8290d9a7
Autor:
Thomas G Beach, Lucia I Sue, Sarah Scott, Anthony J Intorcia, Jessica E Walker, Richard A Arce, Michael J Glass, Claryssa I Borja, Madison P Cline, Spencer J Hemmingsen, Sanaria Qiji, Analisa Stewart, Kayleigh N Martinez, Addison Krupp, Rylee McHattie, Monica Mariner, Ileana Lorenzini, Angela Kuramoto, Kathy E Long, Cécilia Tremblay, Richard J Caselli, Bryan K Woodruff, Steven Z Rapscak, Christine M Belden, Danielle Goldfarb, Parichita Choudhury, Erika D Driver-Dunckley, Shyamal H Mehta, Marwan N Sabbagh, Holly A Shill, Alireza Atri, Charles H Adler, Geidy E Serrano
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 82:457-466
Cerebral white matter rarefaction (CWMR) was considered by Binswanger and Alzheimer to be due to cerebral arteriolosclerosis. Renewed attention came with CT and MR brain imaging, and neuropathological studies finding a high rate of CWMR in Alzheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc7a948f73150d9128a670c619f96e0e
https://doi.org/10.1093/jnen/nlad026
https://doi.org/10.1093/jnen/nlad026
Autor:
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105228- (2021)
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B, with ATP7A mutations also caus
Externí odkaz:
https://doaj.org/article/9e65354b9c964af3a16790973ddace6f
Autor:
David X. Medina, Ashley Boehringer, Marissa Dominick, Ileana Lorenzini, Sara Saez-Atienzar, Erik P. Pioro, Rita Sattler, Bryan Traynor, Robert Bowser
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102141- (2021)
Fibroblasts from an amyotrophic lateral sclerosis patient with simultaneous mutations in the MATR3 gene and KIF5A gene were isolated and reprogrammed into induced pluripotent stem cells via a non-integrating Sendai viral vector. The generated iPSC cl
Externí odkaz:
https://doaj.org/article/dabe6586663848a4a1afb03597796063
Autor:
Alyssa N. Coyne, Ileana Lorenzini, Ching-Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz, Hiroshi Nishimune, Konrad Zinsmaier, Wilfried Rossoll, Rita Sattler, Daniela C. Zarnescu
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 110-125 (2017)
Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS cases. Using a Drosophila model of ALS, we show that TDP-43 overexpression (
Externí odkaz:
https://doaj.org/article/864d5b20cac14a2c8ea1e98ca71ebe07
Autor:
Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G O'Conner, Jordan M Barrows, Alexander Starr, Tina Kovalik, Benjamin E Rabichow, Erik M Lehmkuhl, Dakotah D Shreiner, Archi Joardar, Jean-Charles Liévens, Robert Bowser, Rita Sattler, Daniela C Zarnescu
Publikováno v:
eLife, Vol 8 (2019)
Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 proteinopathy we found significant alterations in glucose metabolism including inc
Externí odkaz:
https://doaj.org/article/988f50fd13f5471a917861ca1a66e325
Autor:
Thomas E. Mahan, Deepti Lall, David M. Holtzman, Rita Sattler, A.K.M. Ghulam Muhammad, Michael Vazquez, Jesse Landeros, Daniel H. Geschwind, Hayk Davtyan, Ileana Lorenzini, Jacqueline G. O’Rourke, Jason D. Ulrich, Thomas A. Mota, Shaughn Bell, Junwon Kim, Jessica E. Rexach, Layla Ghaffari, Oksana Shelest, Mathew Blurton-Jones, Robert H. Baloh
Publikováno v:
Neuron, vol 109, iss 14
C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins. In addition to AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31b1ab4973804c5e9402cb574f064cf
https://escholarship.org/uc/item/9ws7v673
https://escholarship.org/uc/item/9ws7v673
Autor:
Briggs Carhart, Matthew Chaung, Taylor Wingfield, Sam Macklin-Isquierdo, Gary J. Bassell, Alexander Starr, Ileana Lorenzini, Zachary T. McEachin, Daniela C. Zarnescu, Paul R. August, Robert Bowser, Alexandre Betourne, Nadine Bakkar, Robert Kraft, Nicholas M. Boulis, Nathan Zahler, Justin K. Ichida, Samuel V. Alworth, Benjamin E. Rabichow, Wen-Hsuan Chang, Rita Sattler
Publikováno v:
Neurobiology of Disease, Vol 149, Iss, Pp 105228-(2021)
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B, with ATP7A mutations also caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b093cb0d40dc3783f16c5e990d7e3b
http://www.sciencedirect.com/science/article/pii/S0969996120305039
http://www.sciencedirect.com/science/article/pii/S0969996120305039