Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ildiko Elmore"'
Autor:
Douglas W. Morgan, Jennifer J. Bouska, H. Robin Heyman, Patrick A. Marcotte, Yujia Dai, Steven K. Davidsen, Carole L. Goodfellow, Carol K. Wada, Daniel H. Albert, Jamie R. Stacey, Robert B. Garland, Douglas H. Steinman, Paul Tapang, Alan S. Florjancic, Michael L. Curtin, James H. Holms, Yan Guo, Michael R. Michaelides, Ildiko Elmore
Publikováno v:
Journal of Medicinal Chemistry. 45:219-232
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matrix metalloproteinases (MMP) inhibitors. The substitution of the ether linkage of ABT-770 (5) with a sulfone group 13a led to a substantial increase in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d27c6f11163737a28ed10fca7c5bbc9
https://doi.org/10.1021/jm0103920
https://doi.org/10.1021/jm0103920
Autor:
Michael R. Michaelides, James H. Holms, Douglas W. Morgan, Katherine Mast, Steven K. Davidsen, Ildiko Elmore, Lori J. Pease, Keith B. Glaser, Junling Li, Patrick A. Marcotte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2907-2910
Modification of the P 1 ′ substituent of macrocyclic matrix metalloproteinase (MMP) inhibitors provided compounds that are selective for inhibition of tumor necrosis factor-α converting enzyme (TACE) over MMP-1 and MMP-2. Several analogues potentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807e22a4ed221029459cedc3cffedc50
https://doi.org/10.1016/s0960-894x(01)00603-5
https://doi.org/10.1016/s0960-894x(01)00603-5
Autor:
Steven K. Davidsen, Patrick A. Marcotte, Terrance J. Magoc, James H. Holms, Zhiwen Guan, Robert B. Garland, Douglas H. Steinman, Douglas W. Morgan, Daniel H. Albert, Carol K. Wada, Yan Guo, H. Robin Heyman, Michael L. Curtin, George S. Sheppard, Ildiko Elmore
Publikováno v:
Journal of Enzyme Inhibition. 14:425-435
Two series of compounds synthesized as specific matrix metalloproteinase (MMP) inhibitors have been evaluated for their inhibition of non-MMPs. In a series of substituted succinyl hydrox-amic acids, some were found to be significant (IC50 < 1 μM) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34821c159675e7f12526b12b79130320
https://doi.org/10.3109/14756369909030333
https://doi.org/10.3109/14756369909030333
Autor:
Terrance J. Magoc, Yan Guo, Patrick A. Marcotte, George S. Sheppard, Carole L. Goodfellow, Steven K. Davidsen, Lianhong Xu, Alan S. Florjancic, Giesler Jamie, Douglas W. Morgan, Jennifer J. Bouska, Daniel H. Albert, Ildiko Elmore, James B. Summers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3251-3256
A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C-terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec88b7a967bac3f5667f9ff636084372
https://doi.org/10.1016/s0960-894x(98)00597-6
https://doi.org/10.1016/s0960-894x(98)00597-6
Autor:
James H. Holms, Katherine Mast, Douglas W. Morgan, Lori J. Pease, Steven K. Davidsen, Patrick A. Marcotte, Keith B. Glaser, Junling Li, Michael R. Michaelides, Ildiko Elmore
Publikováno v:
ChemInform. 33
Modification of the P 1 ′ substituent of macrocyclic matrix metalloproteinase (MMP) inhibitors provided compounds that are selective for inhibition of tumor necrosis factor-α converting enzyme (TACE) over MMP-1 and MMP-2. Several analogues potentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec9ef5b449c789791c2d3c904f37e961
https://doi.org/10.1002/chin.200209162
https://doi.org/10.1002/chin.200209162