Výsledky vyhledávání - "Ildikó Somlyai"

Akademický článek

Deuterium Content of the Organic Compounds in Food Has an Impact on Tumor Growth in Mice

Autor: Gábor Somlyai, Lajos I. Nagy, László G. Puskás, András Papp, Beáta Z. Kovács, István Fórizs, György Czuppon, Ildikó Somlyai

Publikováno v: Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 66-77 (2022)

Research with deuterium-depleted water (DDW) in the last two decades proved that the deuterium/hydrogen ratio has a key role in cell cycle regulation and cellular metabolism. The present study aimed to investigate the possible effect of deuterium-dep

Externí odkaz: https://doaj.org/article/31e59aaa866f4bd1961b8104612fbbcc

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Akademický článek

A Preliminary Study Indicating Improvement in the Median Survival Time of Glioblastoma Multiforme Patients by the Application of Deuterium Depletion in Combination with Conventional Therapy

Autor: Gábor Somlyai, Beáta Zsuzsanna Kovács, András Papp, Ildikó Somlyai

Publikováno v: Biomedicines, Vol 11, Iss 7, p 1989 (2023)

Glioblastoma multiforme (GBM) and malignant gliomas are the most common primary malignant brain tumors. Temozolomide (TMZ) chemotherapy plus radiation therapy (RT), admi-mistered after debulking surgery, increased the median survival time (MST) from

Externí odkaz: https://doaj.org/article/567765be6eae4cfe956b71989b56e233

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Akademický článek

Blocking the Increase of Intracellular Deuterium Concentration Prevents the Expression of Cancer-Related Genes, Tumor Development, and Tumor Recurrence in Cancer Patients

Autor: Beáta Zs. Kovács, László G. Puskás, Lajos I. Nagy, András Papp, Zoltán Gyöngyi, István Fórizs, György Czuppon, Ildikó Somlyai, Gábor Somlyai

Publikováno v: Cancer Control, Vol 29 (2022)

The possible role of the naturally occurring deuterium in the regulation of cell division was first described in the 1990s. To investigate the mechanism of influence of deuterium (D) on cell growth, expression of 236 cancer-related and 536 kinase gen

Externí odkaz: https://doaj.org/article/2240aece00f047d3a1ccda5381c3b281

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Akademický článek

Deuterium Depletion Inhibits Cell Proliferation, RNA and Nuclear Membrane Turnover to Enhance Survival in Pancreatic Cancer

Autor: László G. Boros, Ildikó Somlyai, Beáta Zs. Kovács, László G. Puskás, Lajos I. Nagy, László Dux, Gyula Farkas, Gábor Somlyai

Publikováno v: Cancer Control, Vol 28 (2021)

The effects of deuterium-depleted water (DDW) containing deuterium (D) at a concentration of 25 parts per million (ppm), 50 ppm, 105 ppm and the control at 150 ppm were monitored in MIA-PaCa-2 pancreatic cancer cells by the real-time cell impedance d

Externí odkaz: https://doaj.org/article/d6c57ec55f4040ef896b87fda44fff11

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Akademický článek

Deuterium-depletion has no significant impact on the mutation rate of Escherichia coli, deuterium abundance therefore has a probabilistic, not deterministic effect on spontaneous mutagenesis.

Autor: Walliyulahi Ajibola, Ildikó Karcagi, Gábor Somlyai, Ildikó Somlyai, Tamás Fehér

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0243517 (2021)

Deuterium (D), the second most abundant isotope of hydrogen is present in natural waters at an approximate concentration of 145-155 ppm (ca. 1.5E-4 atom/atom). D is known to influence various biological processes due to its physical and chemical prop

Externí odkaz: https://doaj.org/article/a6f2c4f86dfa44dd94426da80991b3b2

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Akademický článek

Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome Related and other Blood Parameters in Humans: A Preliminary Study

Autor: Gábor Somlyai, Ildikó Somlyai, István Fórizs, György Czuppon, András Papp, Miklós Molnár

Publikováno v: Molecules, Vol 25, Iss 6, p 1376 (2020)

The effects of deuterium depletion on the human organism have been, except for the antitumor action, seldom investigated by now and the available data are scarce. In oncological patients who also suffered from diabetes and were treated with deuterium

Externí odkaz: https://doaj.org/article/49224c2e36144fcfa32dc706810bbe44

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Deuterium depletion inhibits lung cancer cell growth and migration in vitro and results in severalfold increase of median survival time of non-small cell lung cancer patients receiving conventional therapy

Autor: Gábor Somlyai, Puskás Lg, Papp A, Ildikó Somlyai, Nagy Li, Kovács BZs

Publikováno v: Journal of Cancer Research & Therapy. 9:12-19

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 84% of all lung cancer diagnoses. In advanced NSCLC, including adenocarcinoma and squamous cell carcinoma, median survival time (MST) rarely exceeds 10-12 month

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d0f8ad8bf9016b93842c6a796b50d5
https://doi.org/10.14312/2052-4994.2021-2

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Preliminary Study on the Effect of Systemic Subnormal Deuterium Level on Metabolic Syndrome-Related and Other Blood Parameters in Humans

Autor: Gábor Somlyai, Miklos Z. Molnar, András Papp, Ildikó Somlyai, István Fórizs, György Czuppon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ae1746494e965467cb843648cce514

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Deuterium-depleted Water Stimulates GLUT4 Translocation in the Presence of Insulin, which Leads to Decreased Blood Glucose Concentration

Autor: Katalin Horvath, Beáta Zs. Kovács, Tamas Danko, Ildikó Somlyai, Gábor Somlyai, Miklos Z. Molnar

Publikováno v: Molecular and Cellular Biochemistry

BackgroundDeuterium (D) is a stable isotope of hydrogen (H) with a mass number of 2. It is present in natural waters in the form of HDO, at a concentration of 16.8 mmol/L, equivalent to 150 ppm. In a phase II clinical study, deuterium depletion reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f26a7652a5e752919d55aebc0561251
https://doi.org/10.21203/rs.3.rs-117904/v1

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Deuterium-depletion has no significant impact on the mutation rate of Escherichia coli, deuterium abundance therefore has a probabilistic, not deterministic effect on spontaneous mutagenesis

Autor: Ildikó Somlyai, Gábor Somlyai, Walliyulahi Ajibola, Tamás Fehér, Ildikó Karcagi

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0243517 (2021)
PLoS ONE

Deuterium (D), the second most abundant isotope of hydrogen is present in natural waters at an approximate concentration of 145–155 ppm (ca. 1.5E-4 atom/atom). D is known to influence various biological processes due to its physical and chemical pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755a45333dda8d7180d86d34ac7f0e7d
https://doi.org/10.1371/journal.pone.0243517

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