Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ildar R. Iusupov"'
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1765 (2024)
This work describes the synthesis of spirocyclic compounds based on 8-azaspiro[5.6]dodec-10-ene. Diastereomerically pure pyrrole derivatives were prepared from the spirocyclic 1,2,3-triazole using a coupling reaction. The resulting compounds were cha
Externí odkaz:
https://doaj.org/article/af3397c58c5747d28c4214ca054cc769
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1495 (2022)
The title compound (1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol dihydrochloride was synthesized for the first time in two steps, the first of which was a regioselectivity of epoxide ring-opening reaction under the action of
Externí odkaz:
https://doaj.org/article/b6fbebcd81794dfd93abbb2baf12989d
Autor:
Vladimir N. Ivanov, Mariangela Agamennone, Ildar R. Iusupov, Antonio Laghezza, Anton M. Novoselov, Ekaterina V. Manasova, Andrea Altieri, Paolo Tortorella, Alexander A. Shtil, Alexander V. Kurkin
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103492- (2022)
Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases known to exert multiple regulatory roles in tumor progression. A variety of chemical classes have been explored for targeting individual MMP isoforms. In the present
Externí odkaz:
https://doaj.org/article/e9fe97608448443f80d49ced552688d8
Autor:
Nikita А. Sokolov, Vladimir N. Ivanov, Ildar R. Iusupov, Anton V. Iasevich, Artem V. Trubnikov, Yuliya V. Ulianova, Konstantin А. Lyssenko, Alexander V. Kurkin
Publikováno v:
Chemistry of Heterocyclic Compounds. 58:64-67
Autor:
Alexander V. Kurkin, Francesca Curreli, Ildar R. Iusupov, Evgeniy A. Spiridonov, Shahad Ahmed, Pavel O. Markov, Ekaterina V. Manasova, Andrea Altieri, Asim K. Debnath
Publikováno v:
ChemMedChem. 17
Autor:
Alexander V. Kurkin, Francesca Curreli, Ildar R. Iusupov, Evgeniy A. Spiridonov, Shahad Ahmed, Pavel O. Markov, Ekaterina V. Manasova, Andrea Altieri, Asim K. Debnath
Publikováno v:
ChemMedChem. 17
The envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) plays a critical role in virus entry to the cells by binding to the host cellular protein CD4. Earlier, we reported the design and discovery of a series of highly potent s
Publikováno v:
ChemMedChem. 17(24)
Medicinal chemists are keen to explore tridimensional compounds, especially when it comes to small molecules. It has already been stressed that the majority of known drugs tend to be flat, whereas natural products tend to be more tridimensional and r
Autor:
Alexander V. Kurkin, Ekaterina V. Manasova, Alexander A. Shtil, Antonio Laghezza, Anton M. Novoselov, Vladimir N. Ivanov, Mariangela Agamennone, Paolo Tortorella, Andrea Altieri, Ildar R. Iusupov
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 1, Pp 103492-(2022)
Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases known to exert multiple regulatory roles in tumor progression. A variety of chemical classes have been explored for targeting individual MMP isoforms. In the present
Autor:
Ildar R. Iusupov, Shahad Ahmed, Alexander V. Kurkin, Sofia M. B. Victor, Dmitry S. Belov, Andrea Altieri, Evgeny A. Spiridonov, Asim K. Debnath, Francesca Curreli
Publikováno v:
Bioorg Med Chem
We presented our continuing stride to optimize the second-generation NBD entry antagonist targeted to the Phe43 cavity of HIV-1 gp120. We have synthesized thirty-eight new and novel analogs of NBD-14136, earlier designed based on a CH(2)OH “positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0553c166f5597c90d1731fcf3549e0f4
https://europepmc.org/articles/PMC7856678/
https://europepmc.org/articles/PMC7856678/
Autor:
Pavel O. Markov, Francesca Curreli, Alexander V. Kurkin, Shahad Ahmed, Sofia M. B. Victor, Asim K. Debnath, Dmitry S. Belov, Andrea Altieri, Ildar R. Iusupov
Publikováno v:
J Med Chem
We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analogue, NBD-14189 (Ref1), which showed antiviral activity against HIV-1(HXB2), with a half maximal inhibitory concentratio