Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ilda D'Annessa"'
Autor:
Chloé Rosa-Teijeiro, Victoria Wagner, Audrey Corbeil, Ilda d’Annessa, Philippe Leprohon, Rubens L. do Monte-Neto, Christopher Fernandez-Prada
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background The evolution of drug resistance is one of the biggest challenges in leishmaniasis and has prompted the need for new antileishmanial drugs. Repurposing of approved drugs is a faster and very attractive strategy that is gaining sup
Externí odkaz:
https://doaj.org/article/c3e5eeabebd94c358456bec763a900d7
Autor:
Ilda D’Annessa, Francesco Saverio Di Leva, Anna La Teana, Ettore Novellino, Vittorio Limongelli, Daniele Di Marino
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Peptides and peptidomimetics are strongly re-emerging as amenable candidates in the development of therapeutic strategies against a plethora of pathologies. In particular, these molecules are extremely suitable to treat diseases in which a major role
Externí odkaz:
https://doaj.org/article/595197420a584b1796f84772fa13352d
Autor:
Ilda D’Annessa, Naama Hurwitz, Valentina Pirota, Giovanni Luca Beretta, Stella Tinelli, Mark Woodford, Mauro Freccero, Mehdi Mollapour, Nadia Zaffaroni, Haim Wolfson, Giorgio Colombo
Publikováno v:
Molecules, Vol 25, Iss 2, p 360 (2020)
The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of proteins. As such, Hsp90 has emerged as a suitable candidate for the treatment of a diverse set
Externí odkaz:
https://doaj.org/article/5c05d11695af4b328f06b21e505acc77
Autor:
Greta Bergamaschi, Enrico M. A. Fassi, Alessandro Romanato, Ilda D'Annessa, Maria Teresa Odinolfi, Dario Brambilla, Francesco Damin, Marcella Chiari, Alessandro Gori, Giorgio Colombo, Marina Cretich
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1921 (2019)
The mosquito-borne viral disease caused by the Dengue virus is an expanding global threat. Diagnosis in low-resource-settings and epidemiological surveillance urgently requires new immunoprobes for serological tests. Structure-based epitope predictio
Externí odkaz:
https://doaj.org/article/bd40ff4b3b0c4dce8c3be47e88146c60
Publikováno v:
Antibodies, Vol 8, Iss 1, p 23 (2019)
Peptides and peptidomimetics have attracted revived interest regarding their applications in chemical biology over the last few years. Their chemical versatility, synthetic accessibility and the ease of storage and management compared to full protein
Externí odkaz:
https://doaj.org/article/ac26c23477e444df882175279f2f4696
Autor:
Barbara Arnò, Ilda D'Annessa, Cinzia Tesauro, Laura Zuccaro, Alessio Ottaviani, Birgitta Knudsen, Paola Fiorani, Alessandro Desideri
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68404 (2013)
A human/plasmodial hybrid enzyme, generated by swapping the human topoisomerase IB linker domain with the corresponding domain of the Plasmodium falciparum enzyme, has been produced and characterized. The hybrid enzyme displays a relaxation activity
Externí odkaz:
https://doaj.org/article/8a0c96c003f14353bcff8033c27c5ee8
Autor:
Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Giovanni Chillemi, Yves Pommier, Mark Cushman, Alessandro Desideri
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51354 (2012)
Long-duration comparative molecular dynamics simulations of the DNA-topoisomerase binary and DNA-topoisomerase-indenoisoquinoline ternary complexes have been carried out. The analyses demonstrated the role of the drug in conformationally stabilizing
Externí odkaz:
https://doaj.org/article/c04be8c159174790a6a927538d04d179
Autor:
Amit Roy, Sayan Chowdhury, Souvik Sengupta, Madhumita Mandal, Parasuraman Jaisankar, Ilda D'Annessa, Alessandro Desideri, Hemanta K Majumder
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28493 (2011)
BACKGROUND: The development of 3, 3'-diindolyl methane (DIM) resistant parasite Leishmania donovani (LdDR50) by adaptation with increasing concentrations of the drug generates random mutations in the large and small subunits of heterodimeric DNA topo
Externí odkaz:
https://doaj.org/article/544a5a80c83547f6bfc1741c3835a257
Autor:
Giordano Mancini, Ilda D'Annessa, Andrea Coletta, Nico Sanna, Giovanni Chillemi, Alessandro Desideri
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10934 (2010)
BACKGROUND: Human topoisomerase I catalyzes the relaxation of DNA supercoils in fundamental cell processes like transcription, replication and chromosomal segregation. It is the only target of the camptothecin family of anticancer drugs. Among these,
Externí odkaz:
https://doaj.org/article/207977249e72408f9517a5e719448846
Autor:
Alice Romagnoli, Mattia D’Agostino, Eleonora Pavoni, Chiara Ardiccioni, Stefano Motta, Paolo Crippa, Giorgio Biagetti, Valentina Notarstefano, Jesmina Rexha, Nunzio Perta, Simone Barocci, Brianna K. Costabile, Gabriele Colasurdo, Sara Caucci, Davide Mencarelli, Claudio Turchetti, Marco Farina, Luca Pierantoni, Anna La Teana, Richard Al Hadi, Francesco Cicconardi, Mauro Chinappi, Emiliano Trucchi, Filippo Mancia, Stefano Menzo, Blasco Morozzo della Rocca, Ilda D’Annessa, Daniele Di Marino
Publikováno v:
Nano today. 48
Reliable point-of-care (POC) rapid tests are crucial to detect infection and contain the spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The emergence of several variants of concern (VOC) can reduce binding affinity to diagnos