Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Autor: Wu, Bin, Murray, Justin K., Andrews, Kristin L., Sham, Kelvin, Long, Jason, Aral, Jennifer, Ligutti, Joseph, Amagasu, Shanti, Liu, Dong, Zou, Anruo, Min, Xiaoshan, Wang, Zhulun, Ilch, Christopher P., Kornecook, Thomas J., Lin, Min-Hwa Jasmine, Be, Xuhai, Miranda, Les P., Moyer, Bryan D., Biswas, Kaustav

Publikováno v: Journal of Medicinal Chemistry; 11/8/2018, Vol. 61 Issue 21, p9500-9512, 13p

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.

Autor: Graceffa, Russell F., Boezio, Alessandro A., Able, Jessica, Altmann, Steven, Berry, Loren M., Boezio, Christiane, Butler, John R., Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F., Dineen, Thomas A., Feric Bojic, Elma, Foti, Robert S., Fremeau, Robert T., Guzman-Perez, Angel, Hua Gao, Gunaydin, Hakan, Hongbing Huang, Liyue Huang, Ilch, Christopher

Publikováno v: Journal of Medicinal Chemistry; 7/27/2017, Vol. 60 Issue 14, p5990-6017, 28p

Cerebrovasodilation evoked by stimulation of subthalamic vasodilator area and hypoxia depends upon the integrity of cortical neurons in the rat

Autor: Ilch, Christopher P.¹, Golanov, Eugene V. egolanov@neurosurgery.umsmed.edu

Publikováno v: Neuroscience Letters. Sep2004, Vol. 368 Issue 1, p92-95. 4p.

Engineering Na V 1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics.

Autor: Murray JK, Wu B, Tegley CM, Nixey TE, Falsey JR, Herberich B, Yin L, Sham K, Long J, Aral J, Cheng Y, Netirojjanakul C, Doherty L, Glaus C, Ikotun T, Li H, Tran L, Soto M, Salimi-Moosavi H, Ligutti J, Amagasu S, Andrews KL, Be X, Lin MJ, Foti RS, Ilch CP, Youngblood B, Kornecook TJ, Karow M, Walker KW, Moyer BD, Biswas K, Miranda LP

Publikováno v: ACS chemical biology [ACS Chem Biol] 2019 Apr 19; Vol. 14 (4), pp. 806-818. Date of Electronic Publication: 2019 Mar 27.

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity.

Autor: Graceffa RF, Boezio AA, Able J; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Altmann S, Berry LM, Boezio C, Butler JR, Chu-Moyer M, Cooke M, DiMauro EF, Dineen TA, Feric Bojic E, Foti RS, Fremeau RT Jr, Guzman-Perez A, Gao H, Gunaydin H, Huang H, Huang L, Ilch C, Jarosh M, Kornecook T; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Kreiman CR, La DS, Ligutti J; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Milgram BC, Lin MJ, Marx IE, Nguyen HN, Peterson EA, Rescourio G, Roberts J, Schenkel L, Shimanovich R, Sparling BA, Stellwagen J, Taborn K, Vaida KR, Wang J, Yeoman J, Yu V, Zhu D, Moyer BD; Department of Neuroscience, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Weiss MM

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Jul 27; Vol. 60 (14), pp. 5990-6017. Date of Electronic Publication: 2017 Apr 20.