Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ilary Allodi"'
Autor:
Santiago Mora, Anna Stuckert, Rasmus von Huth Friis, Kimberly Pietersz, Gith Noes-Holt, Roser Montañana-Rosell, Haoyu Wang, Andreas Toft Sørensen, Raghavendra Selvan, Joost Verhaagen, Ilary Allodi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A mice. Such changes in premotor inputs can contribute to homeostatic imbalance of motor neurons. Here, we show that the
Externí odkaz:
https://doaj.org/article/2528f7f26b0f4d03a00277f90da7c3b6
Autor:
Santiago Mora, Anna Stuckert, Rasmus Von Huth-Friis, Kimberly Pietersz, Gith Noes-Holt, Roser Montañana-Rosell, Andreas Toft Sørensen, Joost Verhaagen, Raghavendra Selvan, Ilary Allodi
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S612-S613 (2023)
Externí odkaz:
https://doaj.org/article/b54d49907b7f427b9f8088b803d1091a
Autor:
Santiago Mora, Ilary Allodi
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Action selection is a capital feature of cognition that guides behavior in processes that range from motor patterns to executive functions. Here, the ongoing actions need to be monitored and adjusted in response to sensory stimuli to increase the cha
Externí odkaz:
https://doaj.org/article/8e8e9cd0aba34ad9ada0d35c2fe2361f
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.
Externí odkaz:
https://doaj.org/article/2d524ec808c645ff969f21c21afd1cea
Autor:
Ilary Allodi, Jik Nijssen, Julio Aguila Benitez, Christoph Schweingruber, Andrea Fuchs, Gillian Bonvicini, Ming Cao, Ole Kiehn, Eva Hedlund
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1329-1341 (2019)
Summary: Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would be highly advantageous if motor neuron resilience could be modeled in vitro. Towa
Externí odkaz:
https://doaj.org/article/8aab84b2e94146b09c85298df39a7ab2
Autor:
Richard Mills, Hermes Taylor-Weiner, Jorge C. Correia, Leandro Z. Agudelo, Ilary Allodi, Christina Kolonelou, Vicente Martinez-Redondo, Duarte M.S. Ferreira, Susanne Nichterwitz, Laura H. Comley, Vanessa Lundin, Eva Hedlund, Jorge L. Ruas, Ana I. Teixeira
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 12-22 (2018)
Objective: We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. Methods: A microfluidic device was used to model endocrine signaling and NMJ formation betwee
Externí odkaz:
https://doaj.org/article/db87ccbfe02748bf8d9b5cf1f96d5cac
Publikováno v:
The Journal of Physiology. 598:4385-4403
In vitro studies from transgenic Amyotrophic Lateral Sclerosis models have suggested an increased excitability of spinal motoneurones. However, in vivo intracellular recordings from adult ALS mice models have produced conflicting findings. Previous p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d953e18d4fbea3453e58b009e4e114
https://doi.org/10.1113/jp280097
https://doi.org/10.1113/jp280097
Publikováno v:
The Journal of physiologyReferences. 599(17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ee26fe72142360692c834728c739a0
https://pubmed.ncbi.nlm.nih.gov/34192811
https://pubmed.ncbi.nlm.nih.gov/34192811
Autor:
Ilary Allodi, Arthur J. Cheng, Maja Schlittler, Eva Hedlund, Sebastian Thams, Johanna T. Lanner, Niklas Ivarsson, Daniel C. Andersson, Thomas Chaillou
Publikováno v:
The Journal of Physiology. 597:3133-3146
Key points How defects in muscle contractile function contribute to weakness in amyotrophic lateral sclerosis (ALS) were systematically investigated. Weakness in whole muscles from late stage SOD1G93A mice was explained by muscle atrophy as seen by r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08aecc0d38b77bd8412ba6bae48d1f8
https://doi.org/10.1113/jp277456
https://doi.org/10.1113/jp277456
Publikováno v:
Nature Communications
Allodi, I, Montañana-Rosell, R, Selvan, R, Löw, P & Kiehn, O 2021, ' Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons ', Nature Communications, vol. 12, no. 1, 3251 . https://doi.org/10.1038/s41467-021-23224-7
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Allodi, I, Montañana-Rosell, R, Selvan, R, Löw, P & Kiehn, O 2021, ' Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons ', Nature Communications, vol. 12, no. 1, 3251 . https://doi.org/10.1038/s41467-021-23224-7
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
ALS is characterized by progressive inability to execute movements. Motor neurons innervating fast-twitch muscle-fibers preferentially degenerate. The reason for this differential vulnerability and its consequences on motor output is not known. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccdc89c04a0317bdef7c2aaf98a8855
http://europepmc.org/articles/PMC8166981
http://europepmc.org/articles/PMC8166981