Výsledky vyhledávání - "Ilaria Zuliani"

Akademický článek

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Autor: Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi, Fabio Di Domenico

Publikováno v: Translational Neurodegeneration, Vol 7, Iss 1, Pp 1-22 (2018)

Abstract Background Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demonstrated the disturba

Externí odkaz: https://doaj.org/article/686430605dc74fe99b549d4cf6a953b5

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Akademický článek

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

Autor: Fabio Di Domenico, Antonella Tramutola, Eugenio Barone, Chiara Lanzillotta, Olivia Defever, Andrea Arena, Ilaria Zuliani, Cesira Foppoli, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, D. Allan Butterfield, Marzia Perluigi

Publikováno v: Redox Biology, Vol 23, Iss , Pp - (2019)

Increasing evidences support the notion that the impairment of intracellular degradative machinery is responsible for the accumulation of oxidized/misfolded proteins that ultimately results in the deposition of protein aggregates. These events are ke

Externí odkaz: https://doaj.org/article/c45f2dddd95440b3bc14e86be2fd8383

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Akademický článek

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

Autor: Chiara Lanzillotta, Ilaria Zuliani, Chirag Vasavda, Solomon H. Snyder, Bindu D. Paul, Marzia Perluigi, Fabio Di Domenico, Eugenio Barone

Publikováno v: Antioxidants, Vol 9, Iss 8, p 671 (2020)

Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of mi

Externí odkaz: https://doaj.org/article/d8fa85634e234546a5d747087fbd5740

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Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses

Autor: Antonella Tramutola, Ilaria Zuliani, Fabio Di Domenico

Publikováno v: Expert Review of Proteomics. 16:951-964

Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69906c823f4edee1d8dbab57f059ea43
https://doi.org/10.1080/14789450.2019.1691919

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High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer's Disease Signatures

Autor: Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Claudio Grassi, Eugenio Barone, Francesca Natale, Marzia Perluigi, Ilaria Zuliani, Francesca Cutruzzolà, Serena Rinaldo, Francesco Bellanti, Alessio Paone, Salvatore Fusco, Matteo Spinelli

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3746, p 3746 (2021)

The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake translate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61d62a7cb68f856166653dcc54b1c8a
https://pubmed.ncbi.nlm.nih.gov/33916835

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Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control

Autor: Ilaria Zuliani, Anna Reale, Sara Dule, Michele Zampieri, Marco Giorgio Baroni, Laura Bertoccini, Flavia Agata Cimini, Sara Pagnotta, Eugenio Barone, Maria Gisella Cavallo, Ilaria Barchetta

Aim Biliverdin reductase-A (BVR-A) other than its canonical role in the degradation pathway of heme as partner of heme oxygenase-1 (HO1), has recently drawn attention as a protein with pleiotropic functions involved in insulin-glucose homeostasis. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27781e7c0067298514655f0beaed21ad
http://hdl.handle.net/11573/1573343

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