Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ilaria Tamagno"'
Autor:
Mary R. Doherty, Jenny G. Parvani, Ilaria Tamagno, Damian J. Junk, Benjamin L. Bryson, Hyeon Joo Cheon, George R. Stark, Mark W. Jackson
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-12 (2019)
Abstract Background Highly aggressive, metastatic and therapeutically resistant triple-negative breast cancers (TNBCs) are often enriched for cancer stem cells (CSC). Cytokines within the breast tumor microenvironment (TME) influence the CSC state by
Externí odkaz:
https://doaj.org/article/152bd5a2c671453eb466cf66aed5282a
Autor:
Mark W. Jackson, Nikhila Balasubramaniam, Noah M. Chernosky, Neetha Parameswaran, Sarah E. Taylor, Ilaria Tamagno, Benjamin L. Bryson
Supplemental Information to: Aberrant induction of a mesenchymal/stem-cell program engages senescence in normal mammary epithelial cells S1. Cytokine-induced senescence induces EMT and SC-associated gene expression changes. S2. OSM-mediated Snail ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3dc7a7f3dbe5b72e63af9ca023ab9e
https://doi.org/10.1158/1541-7786.22517119.v1
https://doi.org/10.1158/1541-7786.22517119.v1
Autor:
Mark W. Jackson, Nikhila Balasubramaniam, Noah M. Chernosky, Neetha Parameswaran, Sarah E. Taylor, Ilaria Tamagno, Benjamin L. Bryson
Source Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3040e663e3671bfe9bb138e937523b4a
https://doi.org/10.1158/1541-7786.22517116
https://doi.org/10.1158/1541-7786.22517116
Autor:
Sarah E. Taylor, Mark W. Jackson, Benjamin L. Bryson, Noah M. Chernosky, Ilaria Tamagno, Neetha Parameswaran, Nikhila Balasubramaniam
Publikováno v:
Mol Cancer Res
Although frequently associated with tumor progression, inflammatory cytokines initially restrain transformation by inducing senescence, a key tumor-suppressive barrier. Here, we demonstrate that the inflammatory cytokine, oncostatin M, activates a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85cac28d2d4f34f3bbbd637d122d5bf
https://doi.org/10.1158/1541-7786.mcr-19-1181
https://doi.org/10.1158/1541-7786.mcr-19-1181
Publikováno v:
Curr Protoc
Forward genetics begins with a biological phenotype and attempts to identify genetic changes that influence that phenotype. These changes can be induced in a selected group of genes, for instance, by using libraries of cDNAs, shRNAs, CRISPR guide RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a54e8ed22bf2c61fed147c0075beac
https://europepmc.org/articles/PMC8969887/
https://europepmc.org/articles/PMC8969887/
Autor:
Ilaria Tamagno, Noah M. Chernosky
Publikováno v:
Cancers
Cancers, Vol 13, Iss 5621, p 5621 (2021)
Cancers, Vol 13, Iss 5621, p 5621 (2021)
Simple Summary Overall survival of patients with cancer is dependent on the success of therapy. Therapy failure is correlated with enhanced metastasis and recurrence of the primary tumor. However, metastases may develop before the detection of a prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eef8840278735229f8651f2161650b
http://europepmc.org/articles/PMC8615859
http://europepmc.org/articles/PMC8615859
Autor:
John A. Hammer, Ernest G. Heimsath, Richard E. Cheney, Youwei Zhang, Mark W. Jackson, Ilaria Tamagno, Xinran Geng, Franklin Mayca Pozo
Publikováno v:
Science advances. 7(38)
Genomic instability is a hallmark of human cancer; yet the underlying mechanisms remain poorly understood. Here, we report that the cytoplasmic unconventional Myosin X (MYO10) regulates genome stability, through which it mediates inflammation in canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd248316b2e94174c37839a4f865a0b1
https://pubmed.ncbi.nlm.nih.gov/34524844
https://pubmed.ncbi.nlm.nih.gov/34524844
Publikováno v:
The Journal of Pathology. 245:6-8
Deciphering the complex milieu that makes up the tumor microenvironment (TME) and the signaling engaged by TME cytokines continues to provide novel targets for therapeutic intervention. The IL-6 family member oncostatin M (OSM) has recently emerged a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8f8becda9e5abc9d5d611a09c940535
https://doi.org/10.1002/path.5063
https://doi.org/10.1002/path.5063
Publikováno v:
Cancers
Cancers, Vol 11, Iss 11, p 1716 (2019)
Cancers, Vol 11, Iss 11, p 1716 (2019)
Driven by dysregulated IL-6 family member cytokine signaling in the tumor microenvironment (TME), aberrant signal transducer and activator of transcription (STAT3) and (STAT5) activation have been identified as key contributors to tumorigenesis. Foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7408716ff9cc78d225e71e794a2b63
http://europepmc.org/articles/PMC6895889
http://europepmc.org/articles/PMC6895889
Autor:
Ilaria Tamagno, Mark W. Jackson, Jacob M. Smigiel, Benjamin L. Bryson, Kelsey Polak, Sarah E. Taylor
Publikováno v:
Journal of cancer metastasis and treatment
As a field we have made tremendous strides in treating breast cancer, with a decline in the past 30 years of overall breast cancer mortality. However, this progress is met with little affect once the disease spreads beyond the primary site. With a 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7748b46b719552437273fcf9ddf48847
https://doi.org/10.20517/2394-4722.2019.26
https://doi.org/10.20517/2394-4722.2019.26