Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ilaria Ottonelli"'
Autor:
Ilaria Ottonelli, Jason Thomas Duskey, Filippo Genovese, Francesca Pederzoli, Riccardo Caraffi, Marta Valenza, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100182- (2023)
Externí odkaz:
https://doaj.org/article/e2ad55e74cb94311a24b3ee30c22633c
Autor:
Giulia Birolini, Marta Valenza, Ilaria Ottonelli, Francesca Talpo, Lucia Minoli, Andrea Cappelleri, Mauro Bombaci, Claudio Caccia, Caterina Canevari, Arianna Trucco, Valerio Leoni, Alice Passoni, Monica Favagrossa, Maria Rosaria Nucera, Laura Colombo, Saverio Paltrinieri, Renzo Bagnati, Jason Thomas Duskey, Riccardo Caraffi, Maria Angela Vandelli, Franco Taroni, Mario Salmona, Eugenio Scanziani, Gerardo Biella, Barbara Ruozi, Giovanni Tosi, Elena Cattaneo
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106823- (2023)
Evidence that Huntington's disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly progressing R6/2 mouse model, with a positive therapeutic outcome. Here
Externí odkaz:
https://doaj.org/article/96c6f98820c54018a225e99542b0010a
Autor:
Ilaria Ottonelli, Jason Thomas Duskey, Filippo Genovese, Francesca Pederzoli, Riccardo Caraffi, Marta Valenza, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100136- (2022)
Nanoparticles (NPs) are paving the way for improved treatments for difficult to treat diseases diseases; however, much is unknown about their fate in the body. One important factor is the interaction between NPs and blood proteins leading to the form
Externí odkaz:
https://doaj.org/article/a27122d27e39445c892e505b5b7cf0b2
Autor:
Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calzà
Publikováno v:
Cells, Vol 12, Iss 9, p 1331 (2023)
Spinal cord injury (SCI) is characterized by a cascade of events that lead to sensory and motor disabilities. To date, this condition is irreversible, and no cure exists. To improve myelin repair and limit secondary degeneration, we developed a multi
Externí odkaz:
https://doaj.org/article/59aa99aac00f4692af8891a3ebe9739f
Autor:
Ilaria Ottonelli, Andrea Bighinati, Elisa Adani, François Loll, Riccardo Caraffi, Maria Angela Vandelli, Frank Boury, Giovanni Tosi, Jason Thomas Duskey, Valeria Marigo, Barbara Ruozi
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 25 (2022)
A drawback in the development of treatments that can reach the retina is the presence of barriers in the eye that restrain compounds from reaching the target. Intravitreal injections hold promise for retinal delivery, but the natural defenses in the
Externí odkaz:
https://doaj.org/article/c6c2d3deb8b74808b640c4a0b3e61ce3
Autor:
Jason Thomas Duskey, Arianna Rinaldi, Ilaria Ottonelli, Riccardo Caraffi, Chiara Alessia De Benedictis, Ann Katrin Sauer, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi, Andreas Martin Grabrucker
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1450 (2022)
Glioblastoma Multiforme (GBM) is a devastating disease with a low survival rate and few efficacious treatment options. The fast growth, late diagnostics, and off-target toxicity of currently used drugs represent major barriers that need to be overcom
Externí odkaz:
https://doaj.org/article/540be991bcc843d3bfd60207a7ececc9
Autor:
Jason Thomas Duskey, Ilaria Ottonelli, Arianna Rinaldi, Irene Parmeggiani, Barbara Zambelli, Leon Z. Wang, Robert K. Prud’homme, Maria Angela Vandelli, Giovanni Tosi, Barbara Ruozi
Publikováno v:
Nanomaterials, Vol 11, Iss 11, p 2946 (2021)
Enzymes, as natural and potentially long-term treatment options, have become one of the most sought-after pharmaceutical molecules to be delivered with nanoparticles (NPs); however, their instability during formulation often leads to underwhelming re
Externí odkaz:
https://doaj.org/article/cc555f7c1aad443e92d62c80b5e4a3f9
Autor:
Ilaria Ottonelli, Jason Thomas Duskey, Arianna Rinaldi, Maria Vittoria Grazioli, Irene Parmeggiani, Maria Angela Vandelli, Leon Z. Wang, Robert K. Prud’homme, Giovanni Tosi, Barbara Ruozi
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1495 (2021)
Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control variables, such as the flow rate r
Externí odkaz:
https://doaj.org/article/5b2d4e2b34eb4e918be92bb877010ba8
Autor:
Jason Thomas Duskey, Federica da Ros, Ilaria Ottonelli, Barbara Zambelli, Maria Angela Vandelli, Giovanni Tosi, Barbara Ruozi
Publikováno v:
Molecules, Vol 25, Iss 20, p 4593 (2020)
Enzymes have gained attention for their role in numerous disease states, calling for research for their efficient delivery. Loading enzymes into polymeric nanoparticles to improve biodistribution, stability, and targeting in vivo has led the field wi
Externí odkaz:
https://doaj.org/article/b6f31d55ca6445e181b2ed13a3ae239e
Autor:
Jason Thomas Duskey, Cecilia Baraldi, Maria Cristina Gamberini, Ilaria Ottonelli, Federica Da Ros, Giovanni Tosi, Flavio Forni, Maria Angela Vandelli, Barbara Ruozi
Publikováno v:
Polymers, Vol 12, Iss 4, p 823 (2020)
Discovering new materials to aid in the therapeutic delivery of drugs is in high demand. PLGA, a FDA approved polymer, is well known in the literature to form films or nanoparticles that can load, protect, and deliver drug molecules; however, its inc
Externí odkaz:
https://doaj.org/article/2f94fc604157444f94265f0167ef14f6