Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ilaria Malanchi"'
Autor:
Matteo Massara, Bastien Dolfi, Vladimir Wischnewski, Emma Nolan, Werner Held, Ilaria Malanchi, Johanna A. Joyce
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110284- (2024)
Summary: Brain metastases are the most common brain tumors in patients and are associated with poor prognosis. Investigating the colonization and outgrowth of brain metastases is challenging given the complexity of the organ, tissue sampling difficul
Externí odkaz:
https://doaj.org/article/da5428f9bf474c7dbe061ce7a1009de5
Autor:
Anisha Ramessur, Bana Ambasager, Iker Valle Aramburu, Freddie Peakman, Kelly Gleason, Christoph Lehmann, Venizelos Papayannopoulos, Raoul Charles Coombes, Ilaria Malanchi
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Purpose An elevated number of circulating neutrophils is a poor prognostic factor for breast cancer, where evidence of bone marrow cancer-dependent priming is found. However, how early this priming is detectable remains unclear. Patients and
Externí odkaz:
https://doaj.org/article/ef57165dca85401589110eed0e990aa2
Autor:
Anna Cioce, Beatriz Calle, Tatiana Rizou, Sarah C. Lowery, Victoria L. Bridgeman, Keira E. Mahoney, Andrea Marchesi, Ganka Bineva-Todd, Helen Flynn, Zhen Li, Omur Y. Tastan, Chloe Roustan, Pablo Soro-Barrio, Mahmoud-Reza Rafiee, Acely Garza-Garcia, Aristotelis Antonopoulos, Thomas M. Wood, Tessa Keenan, Peter Both, Kun Huang, Fabio Parmeggian, Ambrosius P. Snijders, Mark Skehel, Svend Kjær, Martin A. Fascione, Carolyn R. Bertozzi, Stuart M. Haslam, Sabine L. Flitsch, Stacy A. Malaker, Ilaria Malanchi, Benjamin Schumann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Changes in glycoprotein expression are correlates of disease, but secreted glycoproteins cannot be accurately traced to their cell line of origin. Here, the authors develop a strategy to chemically tag and profile glycoproteins in a cell line-specifi
Externí odkaz:
https://doaj.org/article/32c82b244eab4f4ebf7b10a1ff93a4d5
Autor:
Irene Rodriguez-Hernandez, Oscar Maiques, Leonie Kohlhammer, Gaia Cantelli, Anna Perdrix-Rosell, Joanne Monger, Bruce Fanshawe, Victoria L. Bridgeman, Sophia N. Karagiannis, Rosa M. Penin, Joaquim Marcolval, Rosa M. Marti, Xavier Matias-Guiu, Gilbert O. Fruhwirth, Jose L. Orgaz, Ilaria Malanchi, Victoria Sanz-Moreno
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
Externí odkaz:
https://doaj.org/article/9e4929d31dc4466f83996eb59f8cabaf
Autor:
Ivana Kurelac, Luisa Iommarini, Renaud Vatrinet, Laura Benedetta Amato, Monica De Luise, Giulia Leone, Giulia Girolimetti, Nikkitha Umesh Ganesh, Victoria Louise Bridgeman, Luigi Ombrato, Marta Columbaro, Moira Ragazzi, Lara Gibellini, Manuela Sollazzo, Rene Gunther Feichtinger, Silvia Vidali, Maurizio Baldassarre, Sarah Foriel, Michele Vidone, Andrea Cossarizza, Daniela Grifoni, Barbara Kofler, Ilaria Malanchi, Anna Maria Porcelli, Giuseppe Gasparre
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Lack of respiratory complex I is a hallmark of oncocytomas. Here the authors show that inactivation of this complex via knockout of the NDUFS3 subunit or using metformin, converts tumors from an aggressive phenotype into low-proliferative oncocytomas
Externí odkaz:
https://doaj.org/article/5695fa0483614fb297fba6aa895d1974
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101277- (2020)
Summary: Neoplastic transformation causing cancer is a key problem in tumor biology and can be triggered by exposure to environmental substances. We investigated whether the cellular composition of a tissue contributes to its predisposition to cancer
Externí odkaz:
https://doaj.org/article/2c131a53d29d4d06ab23e7de87b8ddc0
Autor:
Yaiza del Pozo Martin, Danielle Park, Anassuya Ramachandran, Luigi Ombrato, Fernando Calvo, Probir Chakravarty, Bradley Spencer-Dene, Stefanie Derzsi, Caroline S. Hill, Erik Sahai, Ilaria Malanchi
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2456-2469 (2015)
During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and molecular details of this process remain poorly understood. Here, we found that metastatic
Externí odkaz:
https://doaj.org/article/7e576db4abd54f95ae80761afb321229
Autor:
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M. Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H. Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V. Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimiliano Mazzone, Sara Zanivan, Jan Cools, Hans Wildiers, Véronique Baud, Thomas G. P. Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
Publikováno v:
Nature Cancer. 4:344-364
Publikováno v:
Trends in Cell Biology. 32:979-987
A fundamental requirement for cancer initiation is the activation of developmental programmes by mutant cells. Oncogenic signals often confer an undifferentiated, stem cell-like phenotype that supports the long-term proliferative potential of cancer
Autor:
Emma Nolan, Victoria Louise Bridgeman, Luigi Ombrato, Adam Karoutas, Nicolas Rabas, Celine Angeli Natascha Sewnath, Marcos Vasquez, Felipe Silva Rodrigues, Stuart Horswell, Peter Faull, Rebecca Carter, Ilaria Malanchi
Publikováno v:
Nature Cancer. 3:173-187
Radiotherapy is one of the most effective approaches to achieve tumor control in cancer patients, although healthy tissue injury due to off-target radiation exposure can occur. In this study, we used a model of acute radiation injury to the lung, in