Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ilaria Luccarini"'
Autor:
Arianna Bellucci, Maria Cristina Rosi, Cristina Grossi, Anna Fiorentini, Ilaria Luccarini, Fiorella Casamenti
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 3, Pp 328-338 (2007)
Amyloid plaques and neurofibrillary tangles are the main histopathological hallmarks of Alzheimer's disease (AD). In the neocortex and hippocampus of aged TgCRND8 mice, tau is hyperphosphorylated at different sites recognized by PHF-1, AT100, AT8 and
Externí odkaz:
https://doaj.org/article/f13c99c784eb4aefa7bc580c913c039e
Autor:
Arianna Bellucci, Ilaria Luccarini, Carla Scali, Costanza Prosperi, Maria Grazia Giovannini, Giancarlo Pepeu, Fiorella Casamenti
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 2, Pp 260-272 (2006)
In 7-month-old TgCRND8 mice, the extracellular cortical acetylcholine levels in vivo, the number and morphology of cholinergic neurons in the nucleus basalis magnocellularis and the ability to acquire an inhibitory avoidance response in the step-down
Externí odkaz:
https://doaj.org/article/64aa5d7a456e442ab0e90af32ea37d47
Autor:
Cristina Grossi, Stefania Rigacci, Stefano Ambrosini, Teresa Ed Dami, Ilaria Luccarini, Chiara Traini, Paola Failli, Andrea Berti, Fiorella Casamenti, Massimo Stefani
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71702 (2013)
The claimed beneficial effects of the Mediterranean diet include prevention of several age-related dysfunctions including neurodegenerative diseases and Alzheimer-like pathology. These effects have been related to the protection against cognitive dec
Externí odkaz:
https://doaj.org/article/ee980c16a30c4ec89cf36b9cbb5a6035
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14382 (2010)
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of cognitive functions, extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles within neocortex and hippocampus.
Externí odkaz:
https://doaj.org/article/0b0ec55654f547c197800b06dd400a6f
Autor:
Andrea Lapucci, Massimo Stefani, Daniela Pantano, Andrea Berti, Pamela Nardiello, Leonardo Cavone, Chiara Nediani, Ilaria Luccarini, Caterina Miceli, Fiorella Casamenti
Publikováno v:
Journal of Alzheimer's Disease. 54:737-750
Poly(ADP-ribose) polymerase-1 (PARP1) activation contributes to the cascade of events initiated by amyloid-β (Aβ) peptide eventually leading to cell death in Alzheimer's disease brain. A significant accumulation of PAR polymers and increase of PARP
Autor:
Ilaria Luccarini, Daniela Pantano, Massimo Stefani, Pamela Nardiello, Fiorella Casamenti, Maurizio Servili
Publikováno v:
British Journal of Clinical Pharmacology. 83:54-62
AIM In TgCRND8 (Tg) mice we checked the dose-response effect of diet supplementation with oleuropein aglycone (OLE) at 12.5 or 0.5 mg kg-1 of diet. We also studied the effects of dietary intake of the mix of polyphenols present in olive mill waste wa
Autor:
Maria Camilla Bergonzi, Cristina Grossi, Andrea Torracchi, Anna Rita Bilia, Vieri Piazzini, Clizia Guccione, Fiorella Casamenti, Ilaria Luccarini
Publikováno v:
ChemMedChem. 11:1840-1849
Human serum albumin nanoparticles (NPs) have gained considerable attention owing to their high loading capacity for various drugs and the fact that they are well tolerated. The aim of this work was to investigate two different methods to produce NPs
Autor:
Ilaria Luccarini, Giancarlo la Marca, Massimo Stefani, Fiorella Casamenti, Anna Maria Pugliese, Elisabetta Coppi, Stefania Rigacci, Cristina Grossi, Daniela Pantano, Andrea Berti, Teresa Ed Dami
Publikováno v:
Neurobiology of Aging. 36:648-663
Amyloid-ß (Aß) fragments, oligomeric Aß aggregates, and pyroglutamylated-Aß peptides, as well as epigenetic mechanisms and autophagy dysfunction all appear to contribute in various ways to Alzheimer's disease progression. We previously showed tha
Autor:
Fiorella Casamenti, Stefania Rigacci, Cristina Grossi, Teresa Ed Dami, Ilaria Luccarini, Massimo Stefani
Publikováno v:
Neuroscience Letters. 558:67-72
Previous data have shown that oleuropein aglycone (OLE), the main secoiridoid phenol present in extra virgin olive oil, counteracts in vitro aggregation of the Aβ42 peptide and protects cultured cells and model organisms against aggregates toxicity.
Autor:
Ilaria Luccarini, Stefania Rigacci, Teresa Ed Dami, Fiorella Casamenti, Cristina Grossi, Massimo Stefani
Publikováno v:
Neurodegenerative Diseases. 13:131-134
Background: Translational research needs valid animal models of disease to discover new pathogenetic aspects and treatments. In Alzheimer's disease (AD), transgenic models are of great value for AD research and drug testing. Objective: It was the aim