Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages

Autor: Sara Donzelli, Elisa Milano, Magdalena Pruszko, Andrea Sacconi, Silvia Masciarelli, Ilaria Iosue, Elisa Melucci, Enzo Gallo, Irene Terrenato, Marcella Mottolese, Maciej Zylicz, Alicja Zylicz, Francesco Fazi, Giovanni Blandino, Giulia Fontemaggi

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-15 (2018)

Abstract Background As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control th

Externí odkaz: https://doaj.org/article/a7369b493aa94dc2b68ffa9d49bbb496

Lymphoid EVA1 expression is required for DN1-DN3 thymocytes transition.

Autor: Stefano Iacovelli, Ilaria Iosue, Silvia Di Cesare, Maria Guttinger

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7586 (2009)

BACKGROUND:Thymus organogenesis and T lymphocyte development are accomplished together during fetal life. Proper development and maintenance of thymus architecture depend on signals generated by a sustained crosstalk between developing thymocytes and

Externí odkaz: https://doaj.org/article/d1587739e44d4dc7a917c7e0edcc8fea

Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition

Autor: Sara Donzelli, Teresa Bellissimo, Giorgio Bellotti, Barbara Benassi, Giulia Fontemaggi, Francesco Fazi, Ilaria Iosue, Giovanni Blandino

Publikováno v: RNA Biology

During hematopoiesis it is clearly emerging that microRNAs are integrated with target genes in regulatory circuitries involved in the decisions regarding the ability to self-renew and to generate a differentiated progeny in hematopoietic cells includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d084598ca175b0d0c3984362208fecb
https://doi.org/10.1080/15476286.2015.1044194

Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters

Autor: Frédéric Relaix, Marina Bouché, Francesco Fazi, Silvia Masciarelli, Giovanna Marazzi, Valeria Marrocco, Ilaria Iosue, Luca Madaro, Sonia Alonso-Martin, Piera Smeriglio, David Sassoon

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2016, 30 (4), pp.1404-1415. ⟨10.1096/fj.15-275420⟩
FASEB Journal, 2016, 30 (4), pp.1404-1415. ⟨10.1096/fj.15-275420⟩

International audience; Understanding the regulation of the stem cell fate is fundamental for designing novel regenerative medicine strategies. Previous studies have suggested that pharmacological treatments with small molecules provide a robust and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919f708e5011c2c3f5c984ebf0f47f4b
https://hal.archives-ouvertes.fr/hal-01515295

The methylated DNA immunoprecipitation [MeDIP] to investigate the epigenetic remodeling in cell fate determination and cancer development

Autor: Silvia Masciarelli, Teresa Bellissimo, Francesco Fazi, Ilaria Iosue

Publikováno v: Methods in Molecular Biology ISBN: 9781493931903

Epigenetic mechanisms such as DNA methylation, posttranslational modifications of histone proteins, remodeling of nucleosomes, and the expression of noncoding RNAs contribute to the regulation of gene expression for the cell fate determination and ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54171403dfaa71bfa07ef34f854498a
http://hdl.handle.net/11573/840688