Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ilaria Guerini"'
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23517 (2011)
The DNA-damage checkpoint kinase Chk1 is essential in higher eukaryotes due to its role in maintaining genome stability in proliferating cells. CHK1 gene deletion is embryonically lethal, and Chk1 inhibition in replicating cells causes cell-cycle def
Externí odkaz:
https://doaj.org/article/4d31517ce9114da7bfb8a6972a465376
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 8, p e23517 (2011)
PLoS ONE, Vol 6, Iss 8, p e23517 (2011)
The DNA-damage checkpoint kinase Chk1 is essential in higher eukaryotes due to its role in maintaining genome stability in proliferating cells. CHK1 gene deletion is embryonically lethal, and Chk1 inhibition in replicating cells causes cell-cycle def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29893f479beb9160dedb693f5b31576
http://europepmc.org/articles/PMC3157403
http://europepmc.org/articles/PMC3157403
Meiotic recombination requires the formation of programmed Spo11-dependent DNA double strand breaks (DSBs). In Saccharomyces cerevisiae, the Sae2 protein and the Mre11-Rad50-Xrs2 complex are necessary to remove the covalently attached Spo11 protein f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b560b0e524dbf271d12d91a0f28cb66
http://hdl.handle.net/10281/11547
http://hdl.handle.net/10281/11547
DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, but meiotic cells deliberately introduce them into their genome in order to initiate homologous recombination, which ensures proper homologous chromosome segregation. To minim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2b1b5d8e5dc10fea9296ce3a532887
http://hdl.handle.net/10281/7880
http://hdl.handle.net/10281/7880
DNA double-strand breaks (DSBs) are repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). HR requires 5' DSB end degradation that occurs in the presence of cyclin-dependent kinase (CDK) activity. Here, we show that a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d7401e5abe917b06f86ddc12277e75
http://hdl.handle.net/10281/5297
http://hdl.handle.net/10281/5297
Autor:
Ilaria Guerini, Nicola Manfrini, Hugo Cartagena-Lirola, Giovanna Lucchini, Maria Pia Longhese
DNA double-strand breaks (DSBs) can arise at unpredictable locations after DNA damage or in a programmed manner during meiosis. DNA damage checkpoint response to accidental DSBs during mitosis requires the Rad53 effector kinase, whereas the meiosis-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c8d984fe6e521a21bed0466dd6668c
http://hdl.handle.net/10281/1763
http://hdl.handle.net/10281/1763
DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because failure to repair them can lead to genome rearrangements or chromosome loss. They can arise at unpredictable locations as a consequence of DNA damage during both the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1596f0397b90de2666a93c9ec4b3b1
http://hdl.handle.net/10281/1770
http://hdl.handle.net/10281/1770