Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ilaria Guccini"'
Autor:
Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, Markus Stoffel
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107368- (2023)
Summary: Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC de
Externí odkaz:
https://doaj.org/article/92e4cfa9282e4da99d2e1ee03163bd9e
Autor:
Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà, Andrea Alimonti
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and met
Externí odkaz:
https://doaj.org/article/c5129a2c73bf496996067c83544c9029
Autor:
Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà, Andrea Alimonti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f6425f31869a4c14b0bd184a4c42baaf
Publikováno v:
F1000Research, Vol 7 (2019)
Next generation sequencing protocols such as RNA-seq have made the genome-wide characterization of the transcriptome a crucial part of many research projects in biology. Analyses of the resulting data provide key information on gene expression and in
Externí odkaz:
https://doaj.org/article/e147594e4f62422e9c58959dbccc411a
Autor:
Abdullah Alajati, Ilaria Guccini, Sandra Pinton, Ramon Garcia-Escudero, Tiziano Bernasocchi, Manuela Sarti, Erica Montani, Andrea Rinaldi, Filippo Montemurro, Carlo Catapano, Francesco Bertoni, Andrea Alimonti
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 564-576 (2015)
Understanding the molecular pathways that contribute to the aggressive behavior of HER2-positive breast cancers may aid in the development of novel therapeutic interventions. Here, we show that CDCP1 and HER2 are frequently co-overexpressed in metast
Externí odkaz:
https://doaj.org/article/16633b38cc354fdd8c1e3296009930a1
Autor:
Alberto Toso, Ajinkya Revandkar, Diletta Di Mitri, Ilaria Guccini, Michele Proietti, Manuela Sarti, Sandra Pinton, Jiangwen Zhang, Madhuri Kalathur, Gianluca Civenni, David Jarrossay, Erica Montani, Camilla Marini, Ramon Garcia-Escudero, Eugenio Scanziani, Fabio Grassi, Pier Paolo Pandolfi, Carlo V. Catapano, Andrea Alimonti
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 75-89 (2014)
Summary: Prosenescence therapy has recently emerged as a novel therapeutic approach for treating cancer. However, this concept is challenged by conflicting evidence showing that the senescence-associated secretory phenotype (SASP) of senescent tumor
Externí odkaz:
https://doaj.org/article/c94fd7136b0645978c258289d1966502
Autor:
Nicola Fossati, Francesco Montorsi, Francesco Barletta, Ilaria Guccini, Alberto Briganti, Vito Cucchiara, Giovanni Motterle, Giorgio Gandaglia, Simone Scuderi, R. Jeffrey Karnes, Francesco De Cobelli, Armando Stabile, Francesco Pellegrino, R. Lucianò, Gabriele Sorce
Publikováno v:
BJU International. 129:201-207
Objective: To assess the relationship between the volume of the index lesion (IL) measured at multiparametric magnetic resonance imaging (mpMRI; MRIvol) and at radical prostatectomy (RPvol), stratifying it according to Prostate Imaging-Reporting and
Autor:
Algera Goga, Wenjie Ge, Gerald Schwank, Svenja Godbersen, Karolin Herrmanns, Christian Hirt, Ilaria Guccini, Pamuditha N. Silva, Yuliang He, Markus Stoffel
Publikováno v:
Gastroenterology. 162(1)
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor that is almost uniformly lethal in humans. Activating mutations of KRAS are found in >90% of human PDACs and are sufficient to promote acinar-to-ductal metaplasia
Autor:
Alberto Briganti, Gabriele Sorce, Nicola Fossati, Giorgio Gandaglia, Simone Scuderi, Francesco Montorsi, Antonio Esposito, Giuseppe Cirulli, Giorgio Brembilla, R. Jeffrey Karnes, Francesco De Cobelli, Armando Stabile, Francesco Pellegrino, Ilaria Guccini, Vito Cucchiara, Giovanni Motterle, Elio Mazzone, Francesco Barletta
Introduction Several studies have invariably shown that the risk of Grade Group (GG) upgrading between biopsy and radical prostatectomy (RP) is higher in elderly men. Whether this is due to a real biological effect or to a diagnostic bias is still un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f189500d33910262814a26fa4fc0da
Autor:
Patrik T. Simmler, Cédric Cortijo, Lisa M. Koch, Patricia Galliker, Moritz Schäfer, Silvia Angori, Hella A. Bolck, Christina Mueller, Ana Vukolic, Peter Mirtschink, Yann Christinat, Natalie R. Davidson, Kjong-Van Lehmann, Giovanni Pellegrini, Chantal Pauli, Daniela Lenggenhager, Ilaria Guccini, Till Ringel, Christian Hirt, Gunnar Rätsch, Matthias Peter, Holger Moch, Markus Stoffel, Gerald Schwank
SUMMARYMutations in the splicing factor SF3B1 are frequently occurring in various cancers and drive tumor progression through the activation of cryptic splice sites in multiple genes. Recent studies also demonstrate a positive correlation between exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8fa92c63d44970004c6cf0403dd1f0b
https://doi.org/10.1101/2020.11.10.376780
https://doi.org/10.1101/2020.11.10.376780