Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ilaria Ceppi"'
Autor:
Giordano Reginato, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, Vincent Morin, Elda Cannavo, Ilaria Ceppi, Stefan Braunshier, Ananya Acharya, Virginie Ropars, Jean-Baptiste Charbonnier, Martin Jinek, Andrè Nussenzweig, Taekjip Ha, Petr Cejka
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed repair (HDR) of protein-blocked DSBs requires DNA end resection that is initiated b
Externí odkaz:
https://doaj.org/article/9468f29a4c104f0db450028e4975e766
Autor:
Ilaria Ceppi, Elda Cannavo, Hélène Bret, Rosa Camarillo, Francesca Vivalda, Roshan Singh Thakur, Amador Romero-Franco, Alessandro A. Sartori, Pablo Huertas, Raphaël Guérois, Petr Cejka
Publikováno v:
Genes & Development, 37 (3-4)
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate MRE11-RAD50-NBS1 (MRN) to endonucleolytically cleave 5'-terminated DNA to bypass protein blocks. CtIP also promotes the DNA2 helic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac9824f539b89d495c328ea2f8a122d
https://hdl.handle.net/20.500.11850/605845
https://hdl.handle.net/20.500.11850/605845
Autor:
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre‐Henri Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Petr Cejka
Publikováno v:
The EMBO Journal. 42
The Werner Syndrome helicase, WRN, is a promising therapeutic target in cancers with microsatellite instability (MSI). Long-term MSI leads to the expansion of TA nucleotide repeats proposed to form cruciform DNA structures, which in turn cause DNA br
Autor:
Hanna Törnkvist, Sriram Kk, Sean M. Howard, Robin Öz, Erik Kristiansson, Petr Cejka, Rajhans Sharma, Ilaria Ceppi, Fredrik Westerlund
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117 (35)
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
The early steps of DNA double-strand break (DSB) repair in human cells involve the MRE11-RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP. The roles of these proteins in nucleolytic DSB resection are well characterized, but their role i
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 48 (10)
Nucleic Acids Research, 48 (10)
DNA double-strand breaks are repaired by end-joining or homologous recombination. A key-committing step of recombination is DNA end resection. In resection, phosphorylated CtIP first promotes the endonuclease of MRE11–RAD50–NBS1 (MRN). Subsequent
Autor:
Chiara Balbo Pogliano, Ilaria Ceppi, Sara Giovannini, Vasiliki Petroulaki, Nathan Palmer, Federico Uliana, Marco Gatti, Kristina Kasaciunaite, Raimundo Freire, Ralf Seidel, Matthias Altmeyer, Petr Cejka, Joao Matos
Publikováno v:
Sci Adv
Science Advances, 8 (5)
Science Advances, 8 (5)
Bloom's syndrome is caused by inactivation of the BLM helicase, which functions with TOP3A and RMI1-2 (BTR complex) to dissolve recombination intermediates and avoid somatic crossing-over. We show here that crossover avoidance by BTR further requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c638a716e6250022486f4785ff76525
Autor:
Swagata Halder, Aurore Sanchez, Lepakshi Ranjha, Giordano Reginato, Ilaria Ceppi, Ananya Acharya, Roopesh Anand, Petr Cejka
Publikováno v:
Molecular Cell. 82:3553-3565.e5
RAD51 and the breast cancer suppressor BRCA2 have critical functions in DNA double-strand (dsDNA) break repair by homologous recombination and the protection of newly replicated DNA from nucleolytic degradation. The recombination function of RAD51 re
Autor:
Laëtitia Kermasson, Laurence Maggiorella, Marcel Hohl, Mauro Modesti, John H.J. Petrini, Talia Ileri, Jean-Pierre de Villartay, Marie Chansel-Da Cruz, Petr Cejka, Ilaria Ceppi, Patrick Revy
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2020, 33 (13), pp.108559. ⟨10.1016/j.celrep.2020.108559⟩
Cell Reports, 2020, 33 (13), pp.108559. ⟨10.1016/j.celrep.2020.108559⟩
Cell Reports, 33 (13)
Cell Reports, Elsevier Inc, 2020, 33 (13), pp.108559. ⟨10.1016/j.celrep.2020.108559⟩
Cell Reports, 2020, 33 (13), pp.108559. ⟨10.1016/j.celrep.2020.108559⟩
Cell Reports, 33 (13)
Summary The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e57ab328d251aa59eb99a76bb2cdac0
https://hal-amu.archives-ouvertes.fr/hal-03438613
https://hal-amu.archives-ouvertes.fr/hal-03438613
Autor:
Angharad Wilkie, Ellen G Vernon, Laura Bennett, Christopher J. Staples, Effrosyni Antonopoulou, Katie N. Myers, Aurore Sanchez, Petr Cejka, Ilaria Ceppi, Amelia Gamble, Spencer J. Collis
Publikováno v:
Science Advances
Science Advances, 6 (28)
Science Advances, 6 (28)
The remodeling of stalled replication forks to form four-way DNA junctions is an important component of the replication stress response. Nascent DNA at the regressed arms of these reversed forks is protected by RAD51 and the tumor suppressors BRCA1/2
Publikováno v:
Communications Biology