Forskolin sensitizes pancreatic cancer cells to gemcitabine via Stat3 and Erk1/2 inhibition

Autor: Michela Illiano, Luigi Sapio, Ilaria Caiafa, Emilio Chiosi, Annamaria Spina, Silvio Naviglio

Publikováno v: AIMS Molecular Science, Vol 4, Iss 2, Pp 224-240 (2017)

Cytotoxic chemotherapy, including gemcitabine-based regimens, represents the mainstay of treatment for locally advanced and metastatic pancreatic cancer. However, the response to chemotherapy is absolutely unsatisfactory and the prognosis of pancreat

Externí odkaz: https://doaj.org/article/ccabe375003a4a579284e50bd418287c

Chemical and Biological Characterization of Essential Oils Extracted from Thymus Vulgaris

Autor: Michelina Catauro, Federico Barrino, Salvatore Simone Troise, Luigi Sapio, Michela illiano, Ilaria Caiafa, Silvio Naviglio

The renewed interest in medicinal and aromatic plants and the increase in their market demand have favoured rural development programs for their cultivation, also as a measure to counteract the profound crisis affecting some agricultural sectors. Sag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::7e9ef97aeb2085cfec336f031695a71d
http://hdl.handle.net/11591/466183

Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition

Autor: Annamaria Spina, Alessia Salzillo, Luigi Sapio, Emilio Chiosi, Ilaria Caiafa, Michela Illiano, Silvio Naviglio, Lucia Capasso

Publikováno v: Biochemical pharmacology. 152

Triple negative breast cancer (TNBC) is an invasive, metastatic, highly aggressive tumor. Cytotoxic chemotherapy represents the current treatment for TNBC. However, relapse and chemo-resistance are very frequent. Therefore, new therapeutic approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5413ef76707034979a548c37fec64307
https://pubmed.ncbi.nlm.nih.gov/29574069

Pro-inflammatory cytokines activate hypoxia-inducible factor 3α via epigenetic changes in mesenchymal stromal/stem cells

Autor: Lucia Altucci, Amalia Forte, Marilena Cipollaro, Antonietta Coppola, Gilda Cobellis, Ciro Maione, Lucia Scisciola, Francesca Cuomo, Giuseppina Liguori, Chiara Botti, Ilaria Caiafa, Matilde Valeria Ursini, Umberto Galderisi

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-24221-5
info:cnr-pdr/source/autori:Cuomo F.; Coppola A.; Botti C.; Maione C.; Forte A.; Scisciola L.; Liguori G.; Caiafa I.; Ursini M.V.; Galderisi U.; Cipollaro M.; Altucci L.; Cobellis G./titolo:Pro-inflammatory cytokines activate hypoxia-inducible factor 3? via epigenetic changes in mesenchymal stromal%2Fstem cells/doi:10.1038%2Fs41598-018-24221-5/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8

Human mesenchymal stromal/stem cells (hMSCs) emerged as a promising therapeutic tool for ischemic disorders, due to their ability to regenerate damaged tissues, promote angiogenesis and reduce inflammation, leading to encouraging, but still limited r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6b1d631a69f588608c5a49557f2ee8
https://pubmed.ncbi.nlm.nih.gov/32303693

Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells

Autor: Annamaria Spina, Luigi Sapio, Aurora Daniele, Olga Scudiero, Sabrina Esposito, Filomena Mazzeo, Michela Illiano, Paolo V. Pedone, Andrea Bianco, Ilaria Caiafa, Ersilia Nigro, Silvio Naviglio

Adipokines are known to play a relevant role in a number of cancer related molecular pathways. Adiponectin is a major adipokine with anti-inflammatory and beneficial metabolic actions. Furthermore, it has been shown to exert anti-carcinogenic effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadf5b581e1034f7803a8b718b5af83b
http://hdl.handle.net/11367/59067