Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ilaria Biancofiore"'
Autor:
Wen Torng, Ilaria Biancofiore, Sebastian Oehler, Jin Xu, Jessica Xu, Ian Watson, Brenno Masina, Luca Prati, Nicholas Favalli, Gabriele Bassi, Dario Neri, Samuele Cazzamalli, Jianwen A. Feng
Publikováno v:
ACS Omega, Vol 8, Iss 28, Pp 25090-25100 (2023)
Externí odkaz:
https://doaj.org/article/0d6aaf5a697c4856b4e874e86c014835
Autor:
Wen Torng, Ilaria Biancofiore, Sebastian Oehler, Jin Xu, Jessica Xu, Ian Watson, Brenno Masina, Luca Prati, Nicholas Favalli, Gabriele Bassi, Dario Neri, Samuele Cazzamalli, Jianwen A. Feng
DNA-Encoded Chemical Libraries (DELs) emerged as efficient and cost-effective ligand discovery tools, which enable the generation of protein-ligand interaction data of unprecedented size. In this article, we present an approach that combines DEL scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3f252f9e378ac42763fc66b623f6442
https://doi.org/10.1101/2023.01.25.525453
https://doi.org/10.1101/2023.01.25.525453
Autor:
Georg Kempf, Ignacio Munoz-Sanjuan, Alexandros Patsilinakos, Matteo Andreini, Stefania Colarusso, Vincenzo Summa, Jesus Maria Ontoria Ontoria, Federica Ferrigno, Paola Fezzardi, Steven J. Harper, Leticia Toledo Sherman, Stefan Steinbacher, Ilaria Biancofiore, Esther Torrente, Martin Augustin, Elisabetta Bianchi, Larry Park, Alberto Bresciani, Robert Pacifici, Celia Dominguez
Publikováno v:
ACS Med Chem Lett
[Image: see text] The NRF2-ARE pathway is an intrinsic mechanism of defense against oxidative stress. Inhibition of the interaction between NRF2 and its main negative regulator KEAP1 is an attractive strategy toward neuroprotective agents. We report
Autor:
John E. O'Brien, Caterina Cioffi, Lorenza Ghisu, Manuel Ruether, Ilaria Biancofiore, Daniele Canestrari, Stefano Lancianesi, Mauro F. A. Adamo, Hasim Ibrahim
Publikováno v:
Chemical Science
Canestrari, Daniele ORCID: 0000-0002-3245-6630, Cioffi, Caterina, Biancofiore, Ilaria, Lancianesi, Stefano, Ghisu, Lorenza, Ruether, Manuel, O'Brien, John, Adamo, Mauro F.A. ORCID: 0000-0001-9072-3648 and Ibrahim, Hasim ORCID: 0000-0003-1386-3641 (2019) Sulphide as a leaving group: highly stereoselective bromination of alkyl phenyl sulphides. Chemical Science, 10 (39). ISSN 2041-6520
Canestrari, Daniele ORCID: 0000-0002-3245-6630
A conceptionally novel nucleophilic substitution approach to synthetically important alkyl bromides is presented. Using molecular bromine (Br2), readily available secondary benzyl and tertiary alkyl phenyl sulphides are converted into the correspondi
Autor:
Annalise Di Marco, Alberto Bresciani, Simona Ponzi, Antonella Cellucci, Jesus Maria Ontoria Ontoria, Alina Ciammaichella, Alessandra Francone, Steven J. Harper, Savina Malancona, Maria Veneziano, Vincenzo Summa, Edith Monteagudo, Federica Ferrigno, Emanuela Nizi, Ilaria Biancofiore, Ilaria Rossetti, Paola Pace
Publikováno v:
ACS Medicinal Chemistry Letters. 10:481-486
[Image: see text] The application of class I HDAC inhibitors as cancer therapies is well established, but more recently their development for nononcological indications has increased. We report here on the generation of improved class I selective hum
Autor:
Nadia Gennari, Maria Vittoria Orsale, Vincenzo Summa, Rita Graziani, Simona Ponzi, Jesus Maria Ontoria Ontoria, Alina Ciammaichella, Steven J. Harper, Andreina Basta, Giacomo Paonessa, Ilaria Biancofiore, Valentina Nardi, Federica Ferrigno, Ivan Fini, Melania D'Amico
A previous publication from our laboratory reported the identification of a new class of 2-(1H-imidazo-2-yl)piperazines as potent T. brucei growth inhibitors as potential treatment for Human African Trypanosomiasis (HAT). This work describes the stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb99b1d9838b8c3597fae42fc68fd91
http://hdl.handle.net/11588/828220
http://hdl.handle.net/11588/828220
Autor:
Annalise Di Marco, Steven J. Harper, Savina Malancona, Nadia Gennari, Simona Ponzi, Jesus Maria Ontoria Ontoria, Marcel Kaiser, Rita Graziani, Ilaria Biancofiore, Giacomo Paonessa, Alberto Bresciani, Federica Ferrigno, Vincenzo Summa
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(23-24)
The identification of a new series of growth inhibitors of Trypanosoma brucei rhodesiense, causative agent of Human African Trypanosomiasis (HAT), is described. A selection of compounds from our in-house compound collection was screened in vitro agai
Autor:
Nadia Gennari, Emanuela Nizi, Steven J. Harper, Savina Malancona, Sergio Altamura, Edith Monteagudo, David Roberts, Ilaria Biancofiore, Paul Willis, Maria Vittoria Orsale, Ottavia Cecchetti, Antonella Cellucci, Ralph Laufer, Rita Graziani, Alberto Bresciani, Simona Ponzi, Jesus Maria Ontoria Ontoria, Maria Veneziano, Annalise Di Marco, Giacomo Paonessa, Vincenzo Summa, Federica Ferrigno
Publikováno v:
ACS medicinal chemistry letters. 7(5)
The identification of a new series of P. falciparum growth inhibitors is described. Starting from a series of known human class I HDAC inhibitors a SAR exploration based on growth inhibitory activity in parasite and human cells-based assays led to th
Autor:
Etienne J. Donckele, Gabriele Bassi, Lisa Nadal, Jacopo Millul, Sheila Dakhel Plaza, Eleonore Schmidt, Christian Pellegrino, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Aureliano Zana, Andreas Gloger, Samuele Cazzamalli, Florent Samain, Ilaria Biancofiore
Publikováno v:
Proc Natl Acad Sci U S A
We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with affinity in the subnanomolar concentration range and c