Correction to: SPIKE-1: A Randomised Phase II/III trial in a community setting, assessing use of camostat in reducing the clinical progression of COVID-19 by blocking SARS-CoV-2 Spike protein-initiated membrane fusion

Autor: Sarah Halford, Susan Wan, Ilaria Dragoni, Julie Silvester, Bobojon Nazarov, Daniel Anthony, Suzie Anthony, Emma Ladds, John Norrie, Kevin Dhaliwal, and the CDD SPIKE-1 Project Team

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-1 (2022)

Externí odkaz: https://doaj.org/article/b21f19e815dd45c1a5e94555ef323a1a

Data from A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer

Autor: Ruth Plummer, Udai Banerji, Hector C. Keun, George Petrides, Mihaela Rata, Chris Plummer, Karen Morris, William A. Innes, Elizabeth C. Howell, Alastair Greystoke, Maxime Chénard-Poirier, Becky M. Salisbury, Sarah Potter, Kathrin Heinzmann, Ilaria Dragoni, Philip Sloan, Chris M. Bacon, Geoffrey S. Payne, Stephen R. Wedge, Gareth J. Veal, Sarah Halford

Purpose:Inhibition of monocarboxylate transporter (MCT) 1–mediated lactate transport may have cytostatic and/or cytotoxic effects on tumor cells. We report results from the dose-escalation part of a first-in-human trial of AZD3965, a first-in-class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9da6bf5d5915d482989d62e386cae2f
https://doi.org/10.1158/1078-0432.c.6533131.v2

Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma

Autor: Richard A. Noble, Huw Thomas, Yan Zhao, Lili Herendi, Rachel Howarth, Ilaria Dragoni, Hector C. Keun, Christopher P. Vellano, Joseph R. Marszalek, Stephen R. Wedge

Background We evaluated the therapeutic potential of combining the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 with the mitochondrial respiratory Complex I inhibitor IACS-010759, for the treatment of diffuse large B-cell lymphoma (DLBCL),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd17a33d17f0ddd287dcda7549f62ff
http://hdl.handle.net/10044/1/97953

Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)

Autor: Kathrin Heinzmann, Gareth J. Veal, Laura Brotherton, William Townsend, Martin J. S. Dyer, Chris M. Bacon, Ilaria Dragoni, Pamela McKay, Elizabeth Ruth Plummer, Hector C. Keun, Harriet S. Walter, Kim Linton, Steve R. Wedge, Sarah Halford, Alexandros P. Siskos

Publikováno v: Halford, S E R, Walter, H, McKay, P, Townsend, W, Linton, K, Heinzmann, K, Dragoni, I, Brotherton, L, Veal, G, Siskos, A, Keun, H C, Bacon, C, Wedge, S, Dyer, M J S & Plummer, E R 2021, ' Phase I expansion study of the first-in-class monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ', Journal of Clinical Oncology, vol. 39, no. 15_suppl, pp. 3115-3115 . https://doi.org/10.1200/jco.2021.39.15_suppl.3115
ASCO Annual Meeting I

3115 Background: Tumours rely on lactate transporters (MCT1-4) to maintain glycolytic flux and avoid intracellular acidification. In haematological tumours the MCT1 transporter acts as a lactate and pyruvate exporter. AZD3965 is a potent and specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90d8d48f356d0ee9e4a7761b45a9d92
https://doi.org/10.1200/jco.2021.39.15_suppl.3115

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer

Autor: Roisin NicAmhlaoibh, Robert Clarke, Bruno M Simões, Julia Margaret Wendy Gee, Ilaria Dragoni, Verity Sabin, Andrew H. Sims, Sacha J Howell, Angélica Santiago-Gómez, Elisabeth Trivier

Despite the effectiveness of endocrine therapies to treat estrogen receptor-positive (ER+) breast tumours, two thirds of patients will eventually relapse due tode novoor acquired resistance to these agents. Cancer Stem-like Cells (CSCs), a rare cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534e837c2b0603b87290ebe8850f70da
https://doi.org/10.1101/558528